Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model

Acta Biomaterialia

Volumn 5, Issue 1, 2009, Pages 230-239

  Layman, Hans ^a   Sacasa, Marianne ^a   Murphy, Ashley E ^a   Murphy, Amy M ^a   Pham, Si M ^b   Andreopoulos, Fotios M ^a,b  

^a University of Miami College of Engineering   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Basic fibroblast growth factor; Controlled delivery; Hydrogels; Ischemia

Indexed keywords

BIODEGRADATION; CELL CULTURE; CELL PROLIFERATION; DISEASE CONTROL; ENDOTHELIAL CELLS; FIBROBLASTS; HEALTH RISKS; VEHICLES;

ANGIOGENESIS; BASIC FIBROBLAST GROWTH FACTOR; CO DELIVERIES; CONTROLLED-DELIVERY; DIABETES MELLITUS; ELDERLY POPULATIONS; GRANULOCYTE-COLONY STIMULATING FACTOR; ISCHAEMIA; PERIPHERAL ARTERY DISEASE; REPERFUSION;

HYDROGELS;

ALPHA SMOOTH MUSCLE ACTIN; CD31 ANTIGEN; FIBROBLAST GROWTH FACTOR 2; GELATIN; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT FIBROBLAST GROWTH FACTOR 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC THERAPY; ARTICLE; BOLUS INJECTION; CAPILLARY PROLIFERATION; CELL MIGRATION; CELL PROLIFERATION; COMBINATION CHEMOTHERAPY; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; ENDOMETRIUM CELL; HINDLIMB; HUMAN; HUMAN CELL; HYDROGEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LASER DOPPLER FLOWMETRY; LEG BLOOD FLOW; LEG ISCHEMIA; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

MURINAE;

EID: 56349147736     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2008.07.024     Document Type: Article

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