A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: Chondro-protective effect in a rabbit model of early OA

Journal of Controlled Release

Volumn 187, Issue , 2014, Pages 30-38

  Mero, Anna ^a   Campisi, Monica ^b   Favero, Marta ^c   Barbera, Carlo ^b   Secchieri, Cynthia ^b   Dayer, Jean M ^d   Goldring, Mary B ^e   Goldring, Steven R ^e   Pasut, Gianfranco ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Fidia Advanced Biopolymers   (Italy)

^c UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^e HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Arthritis; Hyaluronic acid; Polymer conjugation; Salmon calcitonin

Indexed keywords

CARTILAGE; DISEASE CONTROL; DISEASES; ENZYME INHIBITION; JOINTS (ANATOMY); ORGANIC ACIDS; POLYMERS;

ARTHRITIS; ARTICULAR CARTILAGES; DISEASE PROGRESSION; HIGH MOLECULAR WEIGHT; MATRIX METALLOPROTEINASES; PHARMACOLOGICAL TREATMENT; SALMON CALCITONIN; THERAPEUTIC EFFECTS;

HYALURONIC ACID;

ALDEHYDE DERIVATIVE; HYALURONIC ACID; POLYPEPTIDE; SALCATONIN; ANTIINFLAMMATORY AGENT; CALCITONIN; CALCIUM; CYCLIC AMP;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CARTILAGE; CARTILAGE DEGENERATION; CATABOLISM; CHONDROPROTECTION; CONTROLLED STUDY; DISEASE COURSE; DRUG CONJUGATION; DRUG EFFICACY; HISTOPATHOLOGY; JOINT CAVITY; MALE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; QUALITY OF LIFE; RABBIT MODEL; RAT; SYNOVIUM; ANIMAL; ARTHRITIS, EXPERIMENTAL; ARTICULAR CARTILAGE; BLOOD; CELL LINE; CHEMISTRY; KNEE; METABOLISM; PATHOLOGY; RABBIT; SPRAGUE DAWLEY RAT; SWINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CALCITONIN; CALCIUM; CARTILAGE, ARTICULAR; CELL LINE; CYCLIC AMP; HYALURONIC ACID; KNEE JOINT; MALE; OSTEOARTHRITIS; RABBITS; RATS, SPRAGUE-DAWLEY; SWINE;

EID: 84901766978     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.008     Document Type: Article

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