Acyclovir Therapy Reduces the CD4+ T Cell Response against the Immunodominant pp65 Protein from Cytomegalovirus in Immune Competent Individuals

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Pachnio, Annette ^a   Begum, Jusnara ^a   Fox, Ashini ^b   Moss, Paul ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; IMMEDIATE EARLY 1 PROTEIN; IMMEDIATE EARLY PROTEIN; UNCLASSIFIED DRUG; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PHOSPHOPROTEIN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOMEGALOVIRUS; DRUG MECHANISM; HUMAN; HUMAN CELL; LOW DRUG DOSE; MAJOR CLINICAL STUDY; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TREATMENT DURATION; TREATMENT RESPONSE; VIRUS IMMUNITY; VIRUS LOAD; VIRUS REPLICATION; CLINICAL TRIAL; CYTOMEGALOVIRUS INFECTIONS; DRUG EFFECTS; FEMALE; GENETICS; IMMUNOLOGY; MALE; MIDDLE AGED;

CYTOMEGALOVIRUS; HERPESVIRIDAE; SIMPLEXVIRUS;

ACYCLOVIR; ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MIDDLE AGED; PHOSPHOPROTEINS; VIRAL MATRIX PROTEINS;

EID: 84928807600     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125287     Document Type: Article

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