Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages 4441-4446

  Finger, Elizabeth C ^a   Castellini, Laura ^a   Rankin, Erinn B ^a   Vilalta, Marta ^a   Krieg, Adam J ^b   Jiang, Dadi ^a   Banh, Alice ^a   Zundel, Wayne ^c   Powell, Marianne Broome ^a   Giaccia, Amato J ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

AKAP12; Melanoma; Metastasis

Indexed keywords

A KINASE ANCHOR PROTEIN 12 VARIANT 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; AKAP12 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; OXYGEN; PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MELANOMA CELL; METASTATIC MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR VOLUME; TUNEL ASSAY; AMINO ACID SEQUENCE; ANIMAL; CANCER TRANSPLANTATION; CELL HYPOXIA; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; MELANOMA; METABOLISM; METASTASIS; MOLECULAR GENETICS; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN TUMOR; TUMOR CELL LINE; TUMOR INVASION;

A KINASE ANCHOR PROTEINS; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOMA; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; OXYGEN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 84928800271     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418164112     Document Type: Article

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