Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8720-8734

  Gelinas, Amy D ^a   Davies, Douglas R ^b   Edwards, Thomas E ^b   Rohloff, John C ^a   Carter, Jeffrey D ^a   Zhang, Chi ^a   Gupta, Shashi ^a   Ishikawa, Yuichi ^c   Hirota, Masao ^c   Nakaishi, Yuichiro ^c   Jarvis, Thale C ^a   Janjic, Nebojsa ^a  

^a SomaLogic Inc   (United States)

^b Emerald BioSystems   (United States)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; BIOMOLECULES; CELL MEMBRANES; LIGANDS; NUCLEIC ACIDS; PROTEINS; SCAFFOLDS (BIOLOGY);

BIOLOGIC ACTIVITIES; CELL SURFACE RECEPTORS; CHRONIC INFLAMMATORY DISEASE; COCRYSTAL STRUCTURE; HYDROPHOBIC INTERACTIONS; INTERMOLECULAR INTERACTIONS; MODIFIED NUCLEOTIDES; SHAPE COMPLEMENTARITY;

IMMUNOLOGY;

GUANINE QUADRUPLEX; INTERLEUKIN 6; PEPTIDE APTAMER; SLOW OFF RATE MODIFIED APTAMER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE MOTIF; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS;

APTAMERS; DNA STRUCTURE; DRUG DISCOVERY; G-QUARTET; INTERLEUKIN; MOLECULAR EVOLUTION; NUCLEIC ACID CHEMISTRY; PROTEIN-NUCLEIC ACID INTERACTION; SELEX;

APTAMERS, NUCLEOTIDE; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HUMANS; INTERLEUKIN-6; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SELEX APTAMER TECHNIQUE;

EID: 84896971960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.532697     Document Type: Article

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