Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients

Annals of Surgery

Volumn 261, Issue 4, 2015, Pages 751-759

  Torrance, Hew Dt ^a,b   Brohi, Karim ^b   Pearse, Rupert M ^a,b   Mein, Charles A ^b   Wozniak, Eva ^b   Prowle, John R ^a   Hinds, Charles J ^a,b   O'Dwyer, Michael J ^a,b  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Blood transfusion; Helper T cells; IL 10; Immunoparalysis; Polytrauma

Indexed keywords

BIOLOGICAL MARKER; FRESH FROZEN PLASMA; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 27; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GATA3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; BLOOD TRANSFUSION; BLOODSTREAM INFECTION; BLUNT TRAUMA; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; GENE EXPRESSION; HELPER CELL; HUMAN; IMMUNE DEFICIENCY; INFLAMMATION; INJURY SCALE; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; PENETRATING TRAUMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; VENTILATED PATIENT; BACTEREMIA; COMORBIDITY; CONTRAINDICATIONS; CROSS INFECTION; FUNGEMIA; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MULTIVARIATE ANALYSIS; PHENOTYPE; YOUNG ADULT;

ADULT; BACTEREMIA; BIOLOGICAL MARKERS; BLOOD TRANSFUSION; CAUSALITY; COMORBIDITY; CROSS INFECTION; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; FUNGEMIA; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION; HUMANS; IMMUNE TOLERANCE; INJURY SEVERITY SCORE; INTERLEUKIN-10; INTERLEUKIN-27; MALE; MULTIPLE TRAUMA; MULTIVARIATE ANALYSIS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PHENOTYPE; RNA, MESSENGER; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84928772440     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000000653     Document Type: Article

References (41)

1. Hill GE, Frawley WH, Griffith KE, et al. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma. 2003;54:908-914.
2. Como JJ, Dutton RP, Scalea TM, et al. Blood transfusion rates in the care of acute trauma. Transfusion. 2004;44:809-813.
3. Report of the US Department of Health and Human Services. The 2009 National Blood Collection and Utilization Survey Report. Washington, DC: US Department of Health and Human Services, Office of the Assistant Secretary for Health; 2011. Available at: http://www.aabb.org/programs/biovigilance/ nbcus/Documents/09-nbcus-report.pdf . Accessed January 29, 2014.
4. Opelz G, Terasaki PI. Improvement of kidney-graft survival with increased numbers of blood transfusions. N Engl J Med. 1978;299:799-803.
5. Cata JP, Wang H, Gottumukkala V, et al. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth. 2013;110:690-701.
6. Flores JM, Jiménez PI, Rincón MD, et al. Early risk factors for sepsis in patients with severe blunt trauma. Injury. 2001;32:5-12.
7. O'Dwyer MJ, Mankan AK, Stordeur P, et al. The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression. Shock. 2006;26:544-550.
8. Pachot A, Monneret G, Voirin N, et al. Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol. 2005;114:61-69.
9. White M, Martin-Loeches I, LawlessMW, et al. Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression. Chest. 2011;139:626-632.
10. Baker SP, O'Neill B, Haddon W, et al. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187-196.
11. American Association for Automotive Medicine (AAAM). The Abbreviated Injury Scale, 1985 Revision. Arlington Heights, IL: AAAM; 1990.
12. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707-710.
13. Cole E, Davenport R, De'Ath H, et al. Coagulation system changes associated with susceptibility to infection in trauma patients. J Trauma Acute Care Surg. 2013;74:51-57.
14. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309-332.
15. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of realtime quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:R34.
16. JMP [computer program]. Version 10. Cary, NC: SAS; 2012.
17. Hunter CA, Kastelein R. Interleukin-27: balancing protective and pathological immunity. Immunity. 2012;37:960-969.
18. Laudanski K, Miller-Graziano C, Xiao W, et al. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci USA. 2006;103:15564-15569.
19. Venet F, Chung C-S, Monneret G, et al. Regulatory T cell populations in sepsis and trauma. J Leukoc Biol. 2008;83:523-535.
20. Campbell DJ, Ziegler SF. FOXP3 modifies the phenotypic and functional properties of regulatory T cells. Nat Rev Immunol. 2007;7:305-310.
21. Ouyang W, Rutz S, Crellin NK, et al. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71-109.
22. Tschoeke SK, Ertel W. Immunoparalysis after multiple trauma. Injury. 2007;38:1346-1357.
23. Cheron A, Floccard B, Allaouchiche B, et al. Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care. 2010;14:R208.
24. Xiao W, Mindrinos MN, Seok J, et al. A genomic storm in critically injured humans. J ExpMed. 2011;208:2581-2590.
25. Vamvakas EC. Possiblemechanisms of allogeneic blood transfusion-associated postoperative infection. Transfus Med Rev. 2002;16:144-160.
26. Vamvakas EC, Blajchman MA. Transfusion-related immunomodulation (TRIM): an update. Blood Rev. 2007;21:327-348.
27. Blajchman MA. Immunomodulation and blood transfusion. Am J Ther. 2002;9:389-395.
28. Baumgartner JM, Nydam TL, Clarke JH, et al. Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells. J Interferon Cytokine Res. 2009;29:333-338.
29. Baumgartner JM, Silliman CC, Moore EE, et al. Stored red blood cell transfusion induces regulatory T cells. J Am Coll Surg. 2009;208:110-119.
30. Escobar GA, Cheng AM, Moore EE, et al. Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes. Ann Surg. 2007;246:129-134.
31. Patel MB, Proctor KG, Majetschak M. Extracellular ubiquitin increases in packed red blood cell units during storage. J Surg Res. 2006;135: 226-232.
32. Jensen LS, Andersen AJ, Christiansen PM, et al. Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg. 1992;79:513-516.
33. Jackman RP, Utter GH, Muench MO, et al. Distinct roles of trauma and transfusion in induction of immune modulation after injury. Transfusion. 2012;52:2533-2550.
34. Cué JI, Peyton JC, Malangoni MA. Does blood transfusion or hemorrhagic shock induce immunosuppression? J Trauma. 1992;32:613-617.
35. Magret M, Amaya-Villar R,Garnacho J, et al.Ventilator-associated pneumonia in trauma patients is associated with lower mortality: results from EU-VAP study. J Trauma. 2010;69:849-854.
36. Apelseth TO, Hervig T, Wentzel-Larsen T, et al. A prospective observational study of the effect of platelet transfusions on levels of platelet-derived cytokines, chemokines and interleukins in acute leukaemia patients with severe chemotherapy-induced cytopenia. Eur Cytokine Netw. 2011;22:52-62.
37. Theusinger OM, Baulig W, Seifert B, et al. Relative concentrations of haemostatic factors and cytokines in solvent/detergent-treated and fresh-frozen plasma. Br J Anaesth. 2011;106:505-511.
38. Graham EA, Tsokos M, Rutty GN. Can post-mortem blood be used for DNA profiling after peri-mortem blood transfusion? Int J Legal Med. 2007;121: 18-23.
39. O'Dwyer MJ,Mankan AK, White M, et al. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. Intensive Care Med. 2008;34:683-691.
40. Hack CJ. Integrated transcriptome and proteome data: the challenges ahead. Brief Funct Genomic Proteomic. 2004;3:212-219.
41. Fu N, Drinnenberg I, Kelso J, et al. Comparison of protein and mRNA expression evolution in humans and chimpanzees. PLoS ONE. 2007;2:e216.