Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression

Chest

Volumn 139, Issue 3, 2011, Pages 626-632

  White, Mary ^a,b   Martin Loeches, Ignacio ^a,c   Lawless, Matthew W ^b   O'Dwyer, Michael J ^a   Doherty, Derek G ^b   Young, Vincent ^a   Kelleher, Dermot ^b   McManus, Ross ^b   Ryan, Thomas ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 23P19; INTERLEUKIN 27P28; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; ELECTIVE SURGERY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL INFECTION; HUMAN; LEUKOCYTE; LUNG LOBECTOMY; LUNG RESECTION; LUNG VENTILATION; POSTOPERATIVE CARE; PRACTICE GUIDELINE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; THORAX SURGERY;

EID: 79952224565     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-0016     Document Type: Article

References (31)

1. Dales RE, Dionne G, Leech JA, Lunau M, Schweitzer I. Preoperative prediction of pulmonary complications following thoracic surgery. Chest. 1993;104(1):155-159. (Pubitemid 23204549)
2. Arozullah AM, Khuri SF, Henderson WG, Daley J; Participants in the National Veterans Affairs Surgical Quality Improvement Program. Development and validation of a multifactorial risk index for predicting postoperative pneumonia after major noncardiac surgery. Ann Intern Med. 2001;135(10):847-857. (Pubitemid 33070681)
3. Döcke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med. 1997;3(6):678-681. (Pubitemid 27264980)
4. Sherry RM, Cue JI, Goddard JK, Parramore JB, DiPiro JT. Interleukin-10 is associated with the development of sepsis in trauma patients. J Trauma. 1996;40(4):613-616. (Pubitemid 126425012)
5. Mira JP, Cariou A, Grall F, et al. Association of TNF2, a TNF-alpha promotor polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA. 1996;282(6):561-568. (Pubitemid 29380293)
6. Azim K, McManus R, Brophy K, Ryan A, Kelleher D, Reynolds JV. Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. Ann Surg. 2007;246(1):122-128. (Pubitemid 47012216)
7. O'Dwyer MJ, Mankan AK, Stordeur P, et al. The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression. Shock. 2006;26(6):544-550. (Pubitemid 44789626)
8. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005;5(7):521-531. (Pubitemid 40961330)
9. O'Dwyer MJ, Mankan AK, White M, et al. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. Intensive Care Med. 2008;34(4):683-691.
10. Centers for Disease Control and Prevention. CDC definitions for nosocomial infections, 1988. Am Rev Respir Dis. 1989;139(4):1058-1059.
11. Stordeur P, Poulin LF, Craciun L, et al. Cytokine mRNA quantification by real-time PCR. J Immunol Methods. 2002;259(1-2):55-64. (Pubitemid 33124384)
12. Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol. 1997;15(15):749-795.
13. Zhang SY, Boisson-Dupuis S, Chapgier A et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008;226:29-40.
14. Condos R, Rom WN, Schluger NW. Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol. Lancet. 1997;349(9064):1513- 1515. (Pubitemid 27216363)
15. Muenzer JT, Davis CG, Dunne BS, Unsinger J, Dunne WM, Hotchkiss RS. Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock. 2006;26(6):565-570.
16. Dhainaut JF, Vincent JL, Richard C, et al. CDP571, a humanized antibody to human tumor necrosis factor-alpha: safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. Crit Care Med. 1995;23(9):1461-1469.
17. Fisher CJ Jr, Agosti JM, Opal SM, et al; The Soluble TNF Receptor Sepsis Study Group. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. N Engl J Med. 1996;334(26):1697-1702.
18. Westendorp RG, Langermans JA, Huizinga TW, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet. 1997;349(9046):170-173.
19. Del Vecchio M, Bajetta E, Canova S, et al. Interleukin-12: biological properties and clinical application. Clin Cancer Res. 2007;13(16):4677-4685.
20. Uhlig HH, McKenzie BS, Hue S, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity. 2006;25(2):309-318.
21. Happel KI, Dubin PJ, Zheng M, et al. Divergent roles for IL-23 and IL-12 in host defense against Klebsiella pneumoniae. JEM. 2005;202(6):761-76 9.
22. Rudner XL, Happel KI, Young EA, et al. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun. 2007;75(6):3055-3061.
23. Miyazaki Y, Yoshida H. Regulation of immune responses by interleukin-27. Immunol Rev. 2008;226:234-247.
24. van Dissel JT, van Langevelde P, Westendorp RG, Kwappenberg K, Frölich M. Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet. 1998;351(9107):950-953.
25. Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock. 2001;16(2):83-96.
26. Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med. 1996;24 (7):1125-1128.
27. Osuchowski MF, Welch K, Siddiqui J, Remick DG. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177(3):1967-1974.
28. White M, Lawless MW, O'Dwyer MJ, et al. Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection. Cytokine. 2010;50(3):322-327.
29. Salomao R, Brunialti MK, Gomes NE, et al. Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock. Crit Care Med. 2009;37(1):132-139.
30. Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285): 104-107.
31. Paul WL, Downs JB. Postoperative atelectasis: Intermittent positive pressure breathing, incentive spirometry, and facemask positive end-expiratory pressure. Arch Surg. 1981;116(7):861-863.