Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis

Oncotarget

Volumn 6, Issue 11, 2015, Pages 9476-9487

  Tabariès, Sébastien ^a,b   Annis, Matthew G ^a,b   Hsu, Brian E ^a,b   Tam, Christine E ^a,b   Savage, Paul ^a,b   Park, Morag ^a,b   Siegel, Peter M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Breast cancer; Claudins; Liver metastasis; Lyn; Src family kinase

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BAFETINIB; CLAUDIN 2; DASATINIB; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE YES; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; CLAUDIN; CLDN2 PROTEIN, HUMAN; LYN PROTEIN-TYROSINE KINASE; MESSENGER RNA; PROTEIN C FOS; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; RNA; TRANSCRIPTION FACTOR AP 1; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER TISSUE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPLANT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IN VIVO STUDY; LIVER METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CARCINOMA; DRUG EFFECTS; EXPERIMENTAL MAMMARY NEOPLASM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LIVER NEOPLASMS; MOLECULARLY TARGETED THERAPY; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; RNA INTERFERENCE; SCID MOUSE; SECONDARY; TRIPLE NEGATIVE BREAST CANCER; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; CLAUDINS; DASATINIB; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; MOLECULAR TARGETED THERAPY; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIMIDINES; RNA INTERFERENCE; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84928750622     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3269     Document Type: Article

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