Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels

Molecular Neurobiology

Volumn 53, Issue 4, 2016, Pages 2152-2160

  Tang, Chao Zhi ^a   Zhang, Yu Ling ^a   Wang, Wen Sheng ^a   Li, Wei Guo ^a   Shi, Ji Peng ^b  

^a HENAN NORMAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Depression; High sensitivity C reactive protein; Homocysteine; Inflammation; Stroke

Indexed keywords

C REACTIVE PROTEIN; HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DSM-IV; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; POSTSTROKE DEPRESSION; PROGNOSIS; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; BLOOD; COMPLICATION; HOSPITALIZATION; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; DEPRESSION; FEMALE; HOMOCYSTEINE; HOSPITALIZATION; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ROC CURVE; STROKE;

EID: 84928746292     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9186-2     Document Type: Article

References (49)

1. Linden T, Blomstrand C, Skoog I (2007) Depressive disorders after 20 months in elderly stroke patients: a case–control study. Stroke 38:1860–1863
2. Cheng SY, Zhao YD, Li J et al (2014) Plasma levels of glutamate during stroke is associated with development of post-stroke depression. Psychoneuroendocrinology 47:126–135
3. Yue W, Xiang L, Zhang YJ et al (2014) Association of serum 25-hydroxyvitamin D with symptoms of depression after 6 months in stroke patients. Neurochem Res 39(11):2218–2224
4. Maes M (2011) Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuro-Psychopharmacol Biol Psychiatry 35(3):664–675
5. Rawdin BJ, Mellon SH, Dhabhar FS et al (2013) Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun 31:143–152
6. Baune BT, Smith E, Reppermund S et al (2012) Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney memory and aging study. Psychoneuroendocrinology 37(9):1521–1530
7. Becking K, Boschloo L, Vogelzangs N et al (2013) The association between immune activation and manic symptoms in patients with a depressive disorder. Transl Psychiatry 3(10):e314
8. Maes M, Berk M, Goehler L et al (2012) Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med 10(1):66
9. Maes M, Meltzer HY, Scharpé S et al (1993) Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: psychopathological correlates of hyperhaptoglobinemia during major depression. Psychiatry Res 47(3):229–241
10. Tu WJ, Zhao SJ, Liu TG et al (2013) Combination of high-sensitivity C-reactive protein and homocysteine predicts the short-term outcomes of Chinese patients with acute ischemic stroke[J]. Neurol Res 35(9):912–921
11. Folstein M, Liu T, Peter I et al (2007) The homocysteine hypothesis of depression[J]. Am J Psychiatry 164(6):861–867
12. Madsen SK, Rajagopalan P, Joshi SH et al (2015) Higher homocysteine associated with thinner cortical gray matter in 803 participants from the Alzheimer’s Disease Neuroimaging Initiative. Neurobiol Aging 36:S203–S210
13. Feng L, Isaac V, Sim S et al (2013) Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults. Am J Geriatr Psychiatr 21(2):164–172
14. Tu W, Yin C, Guo Y et al (2013) Serum homocysteine concentrations in Chinese children with autism. Clin Chem Lab Med 51(2):e19–e22
15. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI (2000) Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 31:1069–1075
16. Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, Taguchi A, Kitagawa K, Kinoshita N, Matsumoto M (2002) Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction. Stroke 33:1493–1496
17. Kim JM, Stewart R, Kim SW et al (2008) Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry 192(4):268–274
18. Yoo JH, Chung CS, Kang SS (1998) Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. Stroke 29:2478–2483
19. Norton SA, Sher-Glass R, Mann S et al (2014) Inflammation and post-stroke depression: preliminary progress. Brain Behav Immun 40:e47
20. Pascoe MC, Crewther SG, Carey LM, et al. (2012) Homocysteine as a potential biochemical marker for depression in elderly stroke survivors. Adv Food Nutr Res, 56
21. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh E (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35–41
22. Brott T, Adams HP, Olinger CP, Marler JR, Barsan WG, Biller J, Hertzberg V (1989) Measurements of acute cerebral infarction: a clinical examination scale. Stroke 20:864–870
23. Sims JR, Gharai LR, Schaefer PW et al (2009) ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology 72(24):2104–2110
24. First MB, Spitzer RL, Gibbon M (1995) Structured clinical interview for DSM-IV axis I disorders—patient edition (SCID-I/P, version 2.0). New York: Biometrics Research Department, New York State Psychiatric Institute
25. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
26. Bonita RBR (1988) Modification of rankin scale: recovery of motor function after stroke. Stroke 19:1497–1500
27. Valkanova V, Ebmeier KP, Allan CL (2013) CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150(3):736–744
28. Nabi H, Bochud M, Glaus J et al (2013) Association of serum homocysteine with major depressive disorder: results from a large population-based study. Psychoneuroendocrinology 38(10):2309–2318
29. Wium-Andersen MK, Orsted DD, Nielsen SF, Nordestgaard BG (2013) Elevated C-reactive protein levels, psychological distress, and depression in 73131 individuals. JAMA Psychiatry 70(2):176–184
30. Nashaat M, Hamdi E, Mawella SA et al (2012) Homocysteine level and depression in patients with ischaemic heart disease. Egypt J Psychiatry 33(2):83
31. Robinson RG (2003) Poststroke depression: prevalence, diagnosis, treatment, and disease progression. Biol Psychiatry 54:376–387
32. Wang X, Li YH, Li MH, Lu J, Zhao JG, Sun XJ, Ye JL (2012) Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression. Eur Arch Psychiatry Neurol Sci 262:33–38
33. Farner L, Wagle J, Engedal K, Flekkøy KM, Wyller TB, Fure B (2010) Depressive symptoms in stroke patients: a 13 month follow-up study of patients referred to a rehabilitation unit. J Affect Disord 127:211–218
34. Jimenez I, Sobrino T, Rodriguez-Yanez M, Pouso M, Cristobo I, Sabucedo M, Castillo J (2009) High serum levels of leptin are associated with post-stroke depression. Psychol Med 39:1201–1209
35. Kim JM, Stewart R, Bae KY, Kim SW, Kang HJ, Shin IS, Yoon JS (2012) Serotonergic and BDNF genes and risk of depression after stroke. J Affect Disord 136:833–840
36. Hafner S, Baghai TC, Eser D, Schule C, Rupprecht R, Bondy B, Bedarida G, von Schacky C (2008) C-reactive protein is associated with polymorphisms of the angiotensin-converting enzyme gene in major depressed patients. J Psychiatr Res 42:163–165
37. Gimeno D, Marmot MG, Singh-Manoux A (2008) Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study. Psychoneuroendocrinology 33:1322–1334
38. Belmaker RH, Agam G (2008) Major depressive disorder. N Engl J Med 358:55–68
39. D’Mello C, Le T, Swain MG (2009) Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor alpha signaling during peripheral organ inflammation. J Neurosci 29:2089–2102
40. Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD (2012) Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci 32:11706–11715
41. Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, Seishima M (2006) The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J Biochem 139:655–662
42. Huang L, Baban B, Johnson BA 3rd, Mellor AL (2010) Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege. Int Rev Immunol 29:133–155
43. Capuron L, Geisler S, Kurz K et al (2014) Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. Curr Pharm Des 20(38):6048–6057
44. Jesmin J, Rashid MS, Jamil H, Hontecillas R, Bassaganya-Riera J (2010) Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension. BMC Med Genet 3(1):45
45. Sanchez-Villegas A, Martinez-Gonzalez MA (2013) Diet, a new target to prevent depression? BMC Med 11:3
46. Cortese GP, Barrientos RM, Maier SF, Patterson SL (2011) Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. J Neurosci 31:4274–4279
47. Bottiglieri T, Laundy M, Crellin R, Toone BK, Carney MW, Reynolds EH (2000) Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 69:228–232
48. Toole JF, Malinow MR, Chambless LE et al (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291(5):565–575
49. Di Napoli M, Papa F, Bocola V (2001) C-reactive protein in ischemic stroke an independent prognostic factor. Stroke 32(4):917–924