Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans

Biological Psychiatry

Volumn 77, Issue 10, 2015, Pages 870-879

  Repunte Canonigo, Vez ^a   Herman, Melissa A ^a   Kawamura, Tomoya ^a   Kranzler, Henry R ^b,c   Sherva, Richard ^d   Gelernter, Joel ^e   Farrer, Lindsay A ^d   Roberto, Marisa ^a   Paolo Sanna, Pietro ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol dependence; Amygdala; Electrophysiology; GABA; Genetic association; Presynaptic mechanisms

Indexed keywords

4 AMINOBUTYRIC ACID; NEUROFIBROMIN; ALCOHOL;

4 AMINOBUTYRIC ACID RELEASE; AFRICAN AMERICAN; ALCOHOL CONSUMPTION; ALCOHOLISM; AMERICAN; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINGE DRINKING; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRINKING BEHAVIOR; EUROPEAN AMERICAN; HEREDITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENETICS; METABOLISM; MINIATURE ENDPLATE POTENTIAL; MOUSE; NERVE CELL; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; CENTRAL AMYGDALOID NUCLEUS; ETHANOL; GAMMA-AMINOBUTYRIC ACID; GENES, NEUROFIBROMATOSIS 1; HUMANS; MICE; MICE, INBRED C57BL; MINIATURE POSTSYNAPTIC POTENTIALS; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84928737603     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.07.031     Document Type: Article

References (34)

1. K. Cichowski, and T. Jacks NF1 tumor suppressor gene function: Narrowing the GAP Cell 104 2001 593 604
2. A.R. Aroor, and S.D. Shukla MAP kinase signaling in diverse effects of ethanol Life Sci 74 2004 2339 2364
3. M.K. Mulligan, I. Ponomarev, R.J. Hitzemann, J.K. Belknap, B. Tabakoff, and R.A. Harris, et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis Proc Natl Acad Sci U S A 103 2006 6368 6373
4. R. Rimondini, C. Arlinde, W. Sommer, and M. Heilig Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol FASEB J 16 2002 27 35
5. H.S. Kalluri, and M.K. Ticku Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain Eur J Pharmacol 439 2002 53 58
6. P.P. Sanna, C. Simpson, R. Lutjens, and G. Koob ERK regulation in chronic ethanol exposure and withdrawal Brain Res 948 2002 186 191
7. M. Roberto, T.E. Nelson, C.L. Ur, M. Brunelli, P.P. Sanna, and D.L. Gruol The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an inhibition of the MAP kinase pathway Eur J Neurosci 17 2003 1646 1654
8. S. Ben Hamida, J. Neasta, A.W. Lasek, V. Kharazia, M. Zou, and S. Carnicella, et al. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors J Neurosci 32 2012 15849 15858
9. V. Repunte-Canonigo, L.D. van der Stap, J. Chen, V. Sabino, U. Wagner, and E.P. Zorrilla, et al. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake Brain Res 1339 2010 1 10
10. R.M. Costa, N.B. Federov, J.H. Kogan, G.G. Murphy, J. Stern, and M. Ohno, et al. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 Nature 415 2002 526 530
11. C. Shilyansky, K.H. Karlsgodt, D.M. Cummings, K. Sidiropoulou, M. Hardt, and A.S. James, et al. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proc Natl Acad Sci U S A 107 2010 13141 13146
12. M. Roberto, S.G. Madamba, S.D. Moore, M.K. Tallent, and G.R. Siggins Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Proc Natl Acad Sci U S A 100 2003 2053 2058
13. M. Roberto, S.G. Madamba, D.G. Stouffer, L.H. Parsons, and G.R. Siggins Increased GABA release in the central amygdala of ethanol-dependent rats J Neurosci 24 2004 10159 10166
14. J.S. Rhodes, K. Best, J.K. Belknap, D.A. Finn, and J.C. Crabbe Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice Physiol Behav 84 2005 53 63
15. J.S. Rhodes, M.M. Ford, C.H. Yu, L.L. Brown, D.A. Finn, T. Garland Jr, and J.C. Crabbe Mouse inbred strain differences in ethanol drinking to intoxication Genes Brain Behav 6 2007 1 18
16. H.C. Becker, and M.F. Lopez Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice Alcohol Clin Exp Res 28 2004 1829 1838
17. V. Repunte-Canonigo, J. Chen, C. Lefebvre, T. Kawamura, M. Kreifeldt, and O. Basson, et al. MeCP2 regulates ethanol sensitivity and intake Addict Biol 19 2014 791 799
18. M. Bajo, M.T. Cruz, G.R. Siggins, R. Messing, and M. Roberto Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proc Natl Acad Sci U S A 105 2008 8410 8415
19. M.A. Herman, C. Contet, N.J. Justice, W. Vale, and M. Roberto Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice J Neurosci 33 2013 3284 3298
20. J. Gelernter, H.R. Kranzler, R. Sherva, L. Almasy, R. Koesterer, and A.H. Smith, et al. Genome-wide association study of alcohol dependence: Significant findings in African- and European-Americans including novel risk loci Mol Psychiatry 19 2014 41 49
21. A. Pierucci-Lagha, J. Gelernter, R. Feinn, J.F. Cubells, D. Pearson, and A. Pollastri, et al. Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) Drug Alcohol Depend 80 2005 303 312
22. J. Gelernter, R. Sherva, R. Koesterer, L. Almasy, H. Zhao, H.R. Kranzler, and L. Farrer Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene Mol Psychiatry 19 2014 41 49
23. L.E. O'Dell, A.J. Roberts, R.T. Smith, and G.F. Koob Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcohol Clin Exp Res 28 2004 1676 1682
24. A.J. Roberts, C.J. Heyser, M. Cole, P. Griffin, and G.F. Koob Excessive ethanol drinking following a history of dependence: Animal model of allostasis Neuropsychopharmacology 22 2000 581 594
25. M.F. Lopez, and H.C. Becker Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice Psychopharmacology (Berl) 181 2005 688 696
26. M. Heilig, M. Egli, J.C. Crabbe, and H.C. Becker Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked? Addict Biol 15 2010 169 184
27. G.F. Koob Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder Curr Top Behav Neurosci 13 2013 3 30
28. A. Pitkanen Connectivity of the rat amygdaloid complex J. Aggleton, The Amygdala: A Functional Analysis 2000 Oxford University Press Oxford, UK 495 589
29. D. Stacey, A. Bilbao, M. Maroteaux, T. Jia, A.C. Easton, and S. Longueville, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release Proc Natl Acad Sci U S A 109 2012 21128 21133
30. M. Ohno, P.W. Frankland, A.P. Chen, R.M. Costa, and A.J. Silva Inducible, pharmacogenetic approaches to the study of learning and memory Nat Neurosci 4 2001 1238 1243
31. R.M. Costa, T. Yang, D.P. Huynh, S.M. Pulst, D.H. Viskochil, A.J. Silva, and C.I. Brannan Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1 Nat Genet 27 2001 399 405
32. L.B. Andersen, R. Ballester, D.A. Marchuk, E. Chang, D.H. Gutmann, and A.M. Saulino A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity Mol Cell Biol 13 1993 487 495
33. J.C. Crabbe, T.J. Phillips, R.A. Harris, M.A. Arends, and G.F. Koob Alcohol-related genes: Contributions from studies with genetically engineered mice Addict Biol 11 2006 195 269
34. D. Goldowitz, D.B. Matthews, K.M. Hamre, G. Mittleman, E.J. Chesler, and H.C. Becker, et al. Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes Alcohol Clin Exp Res 30 2006 1066 1078