Cardiac β1-adrenoceptor autoantibodies in human heart disease: Rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study

European Journal of Heart Failure

Volumn 12, Issue 7, 2010, Pages 753-762

  Deubner, Nikolas ^a   Berliner, Dominik ^a   Schlipp, Angela ^b   Gelbrich, Götz ^c   Caforio, Alida L P ^d   Felix, Stephan B ^e   Fu, Michael ^f   Katus, Hugo ^g   Angermann, Christiane E ^a   Lohse, Martin J ^b   Ertl, Georg ^a   Störk, Stefan ^a   Jahns, Roland ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF PADOVA   (Italy)

^e UNIVERSITY OF GREIFSWALD   (Germany)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autoantibodies; Autoimmunity; Beta adrenergic receptor; Dilated cardiomyopathy; Myocardial infarction; Myocarditis

Indexed keywords

AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR;

ADULT; ANTIBODY PRODUCTION; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; FLUORESCENCE; FOLLOW UP; HEART INFARCTION; HUMAN; INCIDENCE; MALE; MYOCARDITIS; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ANTIBODY SPECIFICITY; AUTOIMMUNITY; HEART MUSCLE; IMMUNOASSAY; IMMUNOLOGY; METHODOLOGY; MULTICENTER STUDY; PATIENT SELECTION;

ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOIMMUNITY; CARDIOMYOPATHY, DILATED; HUMANS; IMMUNOASSAY; MULTICENTER STUDIES AS TOPIC; MYOCARDIAL INFARCTION; MYOCARDITIS; MYOCARDIUM; PATIENT SELECTION; RECEPTORS, ADRENERGIC, BETA-1; RESEARCH DESIGN;

EID: 77954946981     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfq072     Document Type: Article

References (37)

1. American Heart Association D. Heart disease and stroke statistics-2009 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009;119:480-486.
2. Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB. Contemporary definitions and classification of the cardi-omyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Transla-tional Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006;113:1807-1816.
3. Jahns R, Boivin V, Lohse MJ. Beta1-adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med 2006;16: 20-24.
4. Fu M. Autoimmunity and idiopathic dilated cardiomyopathy: where we stand? Autoimmunity 2008;41:415-418.
5. Freedman NJ, Lefkowitz RJ. Anti-beta1-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest 2004;113:1379-1382.
6. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta1-adrenergic receptor directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004;113:1419-1429.
7. Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popovic ZB, Penn MS, Damron DS, Perez DM, Tuohy VK. Beta1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation 2007;116:1-12.
8. Li Y, Heuser JS, Cunningham LC, Kosanke SD, Cunningham MW. Mimicry and antibody-mediated cell signaling in autoimmune myocarditis. J Immunol 2006; 177:8234-8240.
9. Iwata M, Yoshikawa T, Baba A, Anzai T, Mitamura H, Ogawa S. Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardio-myopathy. J Am Coll Cardiol 2001;37:418-424.
10. Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F. Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 1999;99:649-654.
11. Störk S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R. Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. Am Heart J 2006;152:697-704.
12. Nikolaev VO, Boivin V, Stork S, Angermann CE, Ertl G, Lohse MJ, Jahns R. A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. J Am Coll Cardiol 2007;50:423-431.
13. Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM. Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2009;11:119-129.
14. Fu LXM, Magnusson Y, Bergh CH, Waagstein F, Hjalmarson A, Hoebeke J. Localization of a functional autoimmune epitope on the second extracellular loop of the human muscarinic acetylcholine receptor 2 in patients with idiopathic dilated cardiomyopathy. J Clin Invest 1993;91:1964-1968.
15. Leuschner F, Li J, Goser S, Reinhardt L, Ottl R, Bride P, Zehelein J, Pfitzer G, Remppis A, Giannitsis E, Katus HA, Kaya Z. Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction. Eur Heart J 2008;29:1949-1955.
16. Caforio AL, Calabrese F, Angelini A, Tona F, Vinci A, Bottaro S, Ramondo A, Carturan E, Iliceto S, Thiene G, Daliento L. A prospective study of biopsy-proven myocarditis: prognostic relevance of clinical and aetiopathogenetic features at diagnosis. Eur Heart J 2007;28:1326-1333.
17. Felix SB, Staudt A, Landsberger M, Grosse Y, Stangl V, Spielhagen T, Wallukat G, Wernecke KD, Baumann G, Stangl K. Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J Am Coll Cardiol 2002;39:646-652. (Pubitemid 34158161)
18. Caforio AL, Mahon NG, Baig MK, Tona F, Murphy RT, Elliott PM, McKenna WJ. Prospective familial assessment in dilated cardiomyopathy: cardiac autoantibodies predict disease development in asymptomatic relatives. Circulation 2007;115:76-83.
19. Limas CJ, Iakovis P, Anyfantakis A, Kroupis C, Cokkinos DV. Familial clustering of autoimmune diseases in patients with dilated cardiomyopathy. Am J Cardiol 2004; 93:1189-1191.
20. Mehrhof F, Loffler M, Gelbrich G, Ozcelik C, Posch M, Hense HW, Keil U, Scheffold T, Schunkert H, Angermann C, Ertl G, Jahns R, Pieske B, Wachter R, Edelmann F, Wollert KC, Maisch B, Pankuweit S, Erbel R, Neumann T, Herzog W, Katus H, Muller-Tasch T, Zugck C, Dungen HD, Regitz-Zagrosek V, Lehmkuhl E, Stork S, Siebert U, Wasem J, Neumann A, Gohler A, Anker SD, Kohler F, Mockel M, Osterziel KJ, Dietz R, Rauchhaus M. A network against failing hearts-Introducing the German 'Competence Network Heart Failure'. Int J Cardiol 2009;115:236-240.
21. Shaw SM, Shah MK, Williams SG, Fildes JE. Immunological mechanisms of pentox-ifylline in chronic heart failure. Eur J Heart Fail 2009;11:113-118.
22. Staudt A, Hummel A, Ruppert J, Dörr M, Trimpert C, Birkenmeier K, Krieg T, Staudt Y, Felix SB. Immunoadsorption in dilated cardiomyopathy: 6-month results from a randomized study. Am Heart J 2006;152:712e711-712e716.
23. Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, Kuhl U, Maisch B, McKenna WJ, Monserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2008;29:270-276.
24. Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ Jr, Olsen EG, Schoen FJ. Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1987;1:3-14.
25. Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Mullany CJ, Ornato JP, Pearle DL, Sloan MA, Smith SC Jr, Alpert JS, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Gregoratos G, Halperin JL, Hiratzka LF, Hunt SA, Jacobs AK. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction\executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (WritingCommittee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation 2004;110:588-636.
26. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001;16:606-613.
27. Wallukat G, Kaiser A, Wollenberger A. The beta1-adrenoceptor as antigen: functional aspects. Eur Heart J 1995;16(Suppl. 0):85-88.
28. Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. Eur Heart J 2007;28:3076-3093. (Pubitemid 350262258)
29. Kindermann I, Kindermann M, Kandolf R, Klingel K, Bultmann B, Muller T, Lindinger A, Bohm M. Predictors of outcome in patients with suspected myocarditis. Circulation 2008;118:639-648.
30. Frustaci A, Russo MA, Chimenti C. Randomized study on the efficacy of immuno-suppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study. Eur Heart J 2009;30:1995-2002.
31. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Adopted by the 18th WMA General Assembly, Helsiniki, Finland June 1964, last amended by the 59th WMA General Assembly, Seoul, October 2008. World Medical Association; 2008.
32. Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y. Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. J Clin Endocrinol Metab 2005;90:4904-4911.
33. Schulze K, Becker BF, Schauer R, Schultheiss HP. Antibodies to ADP-ATP carrier\an autoantigen in myocarditis and dilated cardiomyopathy\impair cardiac function. Circulation 1990;81:959-969.
34. Warren KG, Catz I, Ferenczi LZ, Krantz MJ. Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-moth double-blind placebo-controlled clinical trial and 5 years of follow-up treatment. Eur J Neurol 2006;13:887-895.
35. Tzartos SJ, Bitzopoulou K, Gavra I, Kordas G, Jacobson L, Kostelidou K, Lagoumintzis G, Lazos O, Poulas K, Sideris S, Sotiriadis A, Trakas N, Zisimopoulou P. Antigen-specific apheresis of pathogenic autoantibodies from myasthenia gravis sera. Ann N Y Acad Sci 2008;1132:291-299.
36. Jahns R, Boivin V, Hein L, Palm D, Nikolaev VO, Müller J, Angermann CE, Ertl G, Lohse MJ. A new cyclic receptor-peptide prevents development of heart dilatation and failure induced by antibodies activating cardiac beta1-adrenergic receptors. Circulation 2005;112(Suppl. II:5):120.
37. Matsui S, Larsson L, Hayase M, Katsuda S, Teraoka K, Kurihara T, Murano H, Nishikawa K, Fu M. Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. J Mol Cell Cardiol 2006;41:78-85.