Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 16, 2015, Pages 4946-4951

  Olafson, Katy N ^a   Ketchum, Megan A ^a   Rimer, Jeffrey D ^a   Vekilov, Peter G ^a,b  

^a UNIVERSITY OF HOUSTON   (United States)

^b University of Houston   (United States)

Author keywords

Chloroquine; Crystal growth inhibition; Crystallization mechanisms; Heme detoxification; Malaria parasites

Indexed keywords

CHLOROQUINE; HEMATIN; ANTIMALARIAL AGENT; HEMIN; SOLVENT; WATER;

ARTICLE; ATOMIC FORCE MICROSCOPY; CRYSTAL; CRYSTALLIZATION; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; MOLECULE; PRIORITY JOURNAL; SOLUTE; ANTAGONISTS AND INHIBITORS; CELL VACUOLE; CHEMISTRY; DRUG EFFECTS; METABOLISM; SURFACE PROPERTY;

ANTIMALARIALS; CHLOROQUINE; CRYSTALLIZATION; HEMIN; MICROSCOPY, ATOMIC FORCE; SOLVENTS; SURFACE PROPERTIES; VACUOLES; WATER;

EID: 84928722256     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501023112     Document Type: Article

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