메뉴 건너뛰기




Volumn 29, Issue 12, 2014, Pages 2228-2234

Warfarin-related nephropathy is the tip of the iceberg: Direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats

Author keywords

Acute kidney injury; Dabigatran; Warfarin related nephropathy

Indexed keywords

1 AMINO 3 CYCLOPROPYLAMINO 7 (4 ISOPROPYLBENZYL) 7H PYRROLO[3,2 F]QUINAZOLINE; CREATININE; DABIGATRAN; WARFARIN; ANTICOAGULANT AGENT; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE;

EID: 84928704225     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft380     Document Type: Article
Times cited : (100)

References (31)
  • 1
    • 70449658993 scopus 로고    scopus 로고
    • Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: A report of 9 cases
    • Brodsky SV, Satoskar A, Chen J et al. Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases. Am J Kidney Dis 2009; 54: 1121-1126
    • (2009) Am J Kidney Dis , vol.54 , pp. 1121-1126
    • Brodsky, S.V.1    Satoskar, A.2    Chen, J.3
  • 2
    • 77951075487 scopus 로고    scopus 로고
    • Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease
    • Brodsky SV, Collins M, Park E et al. Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease. Nephron Clin Pract 2010; 115: c142-c146
    • (2010) Nephron Clin Pract , vol.115 , pp. c142-c146
    • Brodsky, S.V.1    Collins, M.2    Park, E.3
  • 3
    • 79959774679 scopus 로고    scopus 로고
    • Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate
    • Brodsky SV, Nadasdy T, Rovin BH et al. Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney Int 2011; 80: 181-189
    • (2011) Kidney Int , vol.80 , pp. 181-189
    • Brodsky, S.V.1    Nadasdy, T.2    Rovin, B.H.3
  • 4
    • 84859121836 scopus 로고    scopus 로고
    • 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy
    • Ozcan A, Ware K, Calomeni E et al. 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy. Am J Nephrol 2012; 35: 356-364
    • (2012) Am J Nephrol , vol.35 , pp. 356-364
    • Ozcan, A.1    Ware, K.2    Calomeni, E.3
  • 5
    • 80053491983 scopus 로고    scopus 로고
    • Warfarin-related nephropathy modeled by nephron reduction and excessive anticoagulation
    • Ware K, Brodsky P, Satoskar AA et al. Warfarin-related nephropathy modeled by nephron reduction and excessive anticoagulation. J Am Soc Nephrol 2011; 22: 1856-1862
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1856-1862
    • Ware, K.1    Brodsky, P.2    Satoskar, A.A.3
  • 8
    • 84867762298 scopus 로고    scopus 로고
    • PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats
    • Manaenko A, Sun X, Kim CH et al. PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats. Neurobiol Dis 2013; 50: 13-20
    • (2013) Neurobiol Dis , vol.50 , pp. 13-20
    • Manaenko, A.1    Sun, X.2    Kim, C.H.3
  • 9
    • 84861456104 scopus 로고    scopus 로고
    • Inhibition of proinflammatory cytokines by SCH79797, a selective protease-activated receptor 1 antagonist, protects rat kidney against ischemia-reperfusion injury
    • El Eter EA, Aldrees A. Inhibition of proinflammatory cytokines by SCH79797, a selective protease-activated receptor 1 antagonist, protects rat kidney against ischemia-reperfusion injury. Shock 2012; 37: 639-644
    • (2012) Shock , vol.37 , pp. 639-644
    • El Eter, E.A.1    Aldrees, A.2
  • 10
    • 0031984347 scopus 로고    scopus 로고
    • Ecarin clotting time: A predictive coagulation assay for the antithrombotic activity of argatroban in the rat
    • Berry CN, Lunven C, Girardot C et al. Ecarin clotting time: a predictive coagulation assay for the antithrombotic activity of argatroban in the rat. Thromb Haemost 1998; 79: 228-233
    • (1998) Thromb Haemost , vol.79 , pp. 228-233
    • Berry, C.N.1    Lunven, C.2    Girardot, C.3
  • 11
    • 34547924093 scopus 로고    scopus 로고
    • Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats
    • Wienen W, Stassen JM, Priepke H et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost 2007; 98: 333-338
    • (2007) Thromb Haemost , vol.98 , pp. 333-338
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 12
    • 34447522035 scopus 로고    scopus 로고
    • In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    • Wienen W, Stassen JM, Priepke H et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thromb Haemost 2007; 98: 155-162
    • (2007) Thromb Haemost , vol.98 , pp. 155-162
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 13
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • Stangier J. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 2008; 47: 285-295
    • (2008) Clin Pharmacokinet , vol.47 , pp. 285-295
    • Stangier, J.1
  • 14
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • Stangier J, Stahle H, Rathgen K et al. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 2008; 47: 47-59
    • (2008) Clin Pharmacokinet , vol.47 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3
  • 15
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • Blech S, Ebner T, Ludwig-Schwellinger E et al. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 2008; 36: 386-399
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3
  • 16
    • 84857015053 scopus 로고    scopus 로고
    • Laboratory testing of anticoagulants: The present and the future
    • Favaloro EJ, Lippi G, Koutts J. Laboratory testing of anticoagulants: the present and the future. Pathology 2011; 43: 682-692
    • (2011) Pathology , vol.43 , pp. 682-692
    • Favaloro, E.J.1    Lippi, G.2    Koutts, J.3
  • 17
    • 4143113354 scopus 로고    scopus 로고
    • Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing
    • Gosselin RC, King JH, Janatpour KA et al. Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. Ann Pharmacother 2004; 38: 1383-1388
    • (2004) Ann Pharmacother , vol.38 , pp. 1383-1388
    • Gosselin, R.C.1    King, J.H.2    Janatpour, K.A.3
  • 18
    • 84877862997 scopus 로고    scopus 로고
    • The pharmacology and therapeutic use of dabigatran etexilate
    • Spinler S. The pharmacology and therapeutic use of dabigatran etexilate. J Clin Pharmacol 2013; 53: 1-13
    • (2013) J Clin Pharmacol , vol.53 , pp. 1-13
    • Spinler, S.1
  • 19
    • 84870220837 scopus 로고    scopus 로고
    • Direct thrombin inhibitors: A case indicating benefit from 'plasmapheresis' in toxicity: A call for establishing 'guidelines' in overdose and to find an 'antidote'
    • Kamboj J, Kottalgi M, Cirra VR et al. Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing 'guidelines' in overdose and to find an 'antidote'! Am J Ther 2012; 19: e182-e185
    • (2012) Am J Ther , vol.19 , pp. e182-e185
    • Kamboj, J.1    Kottalgi, M.2    Cirra, V.R.3
  • 20
    • 84872356086 scopus 로고    scopus 로고
    • Implications of new anticoagulants in primary practice
    • Perez A, Eraso LH, Merli GJ. Implications of new anticoagulants in primary practice. Int J Clin Pract 2013; 67: 139-156
    • (2013) Int J Clin Pract , vol.67 , pp. 139-156
    • Perez, A.1    Eraso, L.H.2    Merli, G.J.3
  • 21
    • 84875922941 scopus 로고    scopus 로고
    • Fatal dabigatran toxicity secondary to acute renal failure
    • Maddry JK, Amir MK, Sessions D et al. Fatal dabigatran toxicity secondary to acute renal failure. Am J Emerg Med 2013; 31: 462. e1-462.e2
    • (2013) Am J Emerg Med , vol.31 , pp. 462e1-462e2
    • Maddry, J.K.1    Amir, M.K.2    Sessions, D.3
  • 22
    • 84862243930 scopus 로고    scopus 로고
    • Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients
    • Bene J, Said W, Rannou M et al. Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients. Ann Pharmacother 2012; 46: e14
    • (2012) Ann Pharmacother , vol.46 , pp. e14
    • Bene, J.1    Said, W.2    Rannou, M.3
  • 23
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • Wychowski MK, Kouides PA. Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother 2012; 46: e10
    • (2012) Ann Pharmacother , vol.46 , pp. e10
    • Wychowski, M.K.1    Kouides, P.A.2
  • 24
    • 84878106189 scopus 로고    scopus 로고
    • Positive outcome after intentional overdose of dabigatran
    • Woo JS, Kapadia N, Phanco SE et al. Positive outcome after intentional overdose of dabigatran. J Med Toxicol 2013; 9: 192-195
    • (2013) J Med Toxicol , vol.9 , pp. 192-195
    • Woo, J.S.1    Kapadia, N.2    Phanco, S.E.3
  • 25
    • 84871276049 scopus 로고    scopus 로고
    • New avenues for anticoagulation in atrial fibrillation
    • Mantha S, Cabral K, Ansell J. New avenues for anticoagulation in atrial fibrillation. Clin Pharmacol Ther 2013; 93: 68-77
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 68-77
    • Mantha, S.1    Cabral, K.2    Ansell, J.3
  • 26
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005; 3: 1800-1814
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 27
    • 0034921205 scopus 로고    scopus 로고
    • Protease-activated receptors in vascular biology
    • Coughlin SR. Protease-activated receptors in vascular biology. Thromb Haemost 2001; 86: 298-307
    • (2001) Thromb Haemost , vol.86 , pp. 298-307
    • Coughlin, S.R.1
  • 28
    • 34547132787 scopus 로고    scopus 로고
    • Endothelial cytoskeletal reorganization in response to PAR1 stimulation is mediated by membrane rafts but not caveolae
    • Carlile-Klusacek M, Rizzo V. Endothelial cytoskeletal reorganization in response to PAR1 stimulation is mediated by membrane rafts but not caveolae. Am J Physiol Heart Circ Physiol 2007; 293: H366-H375
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H366-H375
    • Carlile-Klusacek, M.1    Rizzo, V.2
  • 29
    • 0034864817 scopus 로고    scopus 로고
    • Role of thrombin receptors in the kidney: Lessons from PAR1 knock-out mice
    • Rondeau E, Vigneau C, Berrou J. Role of thrombin receptors in the kidney: lessons from PAR1 knock-out mice. Nephrol Dial Transplant 2001; 16: 1529-1531
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 1529-1531
    • Rondeau, E.1    Vigneau, C.2    Berrou, J.3
  • 30
    • 0028814818 scopus 로고
    • Constitutive expression and modulation of the functional thrombin receptor in the human kidney
    • Xu Y, Zacharias U, Peraldi MN et al. Constitutive expression and modulation of the functional thrombin receptor in the human kidney. Am J Pathol 1995; 146: 101-110
    • (1995) Am J Pathol , vol.146 , pp. 101-110
    • Xu, Y.1    Zacharias, U.2    Peraldi, M.N.3
  • 31
    • 79954499013 scopus 로고    scopus 로고
    • Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: For and against
    • Favaloro EJ, Lippi G. Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: for and against? Clin Chem Lab Med 2011; 49: 755-757
    • (2011) Clin Chem Lab Med , vol.49 , pp. 755-757
    • Favaloro, E.J.1    Lippi, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.