Laboratory testing and/or monitoring of the new oral anticoagulants/ antithrombotics: For and against?

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 5, 2011, Pages 755-757

  Favaloro, Emmanuel J ^a   Lippi, Giuseppe ^b  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

antithrombotics; apixaban; dabigatran; laboratory testing; monitoring; oral anticoagulants; rivaroxaban

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; ARGATROBAN; DABIGATRAN; FONDAPARINUX; HEPARIN; RIVAROXABAN; VITAMIN K GROUP;

ANTICOAGULANT THERAPY; BLEEDING; DEEP VEIN THROMBOSIS; DRUG COST; DRUG EFFICACY; DRUG MONITORING; DRUG SAFETY; EDITORIAL; EMBOLISM PREVENTION; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INTERNATIONAL NORMALIZED RATIO; LABORATORY TEST; LUNG EMBOLISM; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOEMBOLISM; THROMBOSIS; THROMBOSIS PREVENTION; TISSUE NECROSIS;

ADMINISTRATION, ORAL; ANTICOAGULANTS; FIBRINOLYTIC AGENTS; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES;

EID: 79954499013     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.126     Document Type: Editorial

References (20)

1. Samama MM, Guinet C Laboratory assessments of new anti-coagulants. Clin Chem Lab Med 2011;49:761-72.
2. Favaloro EJ, Lippi G, Franchini M. Coagulopathies and throm-bosis: usual and unusual causes and associations, part III. Semin Thromb Hemost 2010;36:1-5.
3. Lippi G, Franchini M. Pathogenesis of venous thromboembo-lism: when the cup runneth over. Semin Thromb Hemost 2008; 34:747-61.
4. Lippi G, Franchini M, Favaloro EJ. Pharmacogenetics of vitamin K antagonists: useful or hype? Clin Chem Lab Med 2009; 47:503-15.
5. Rumilla K, Chen D, Baudhuin LM. Pharmacogenetics in hemo-stasis: friend or foe? Semin Thromb Hemost 2009;35:42-9.
6. Lippi G, Favaloro EJ. Activated partial thromboplastin time: new tricks for an old dogma. Semin Thromb Hemost 2008;34: 604-11.
7. Manzato F, Mengoni A, Grilenzoni A, Lippi G Evaluation of the activated partial thromboplastin time (APTT) sensitivity to heparin using five commercial reagents: implications for thera-peutic monitoring. Clin Chem Lab Med 1998;36:975-80. (Pubitemid 29010110)
8. Favaloro EJ, Adcock DM. Standardization of the INR: how good is your laboratory's INR and can it be improved? Semin Thromb Hemost 2008;34:593-603.
9. Nydegger UE, Gygax E, Carrel T. Point-of-care testing in the cardiovascular operating theatre. Clin Chem Lab Med 2006;44: 1060-5. (Pubitemid 44370922)
10. Favaloro EJ, McVicker W, Hamdam S, Hocker N. Improving the harmonisation of the international normalized ratio (INR): time to think outside the box? Clin Chem Lab Med 2010;48: 1079-90.
11. Favaloro EJ, Lippi G, Adcock DM. Preanalytical and post-analytical variables: the leading causes of diagnostic error in haemostasis? Semin Thromb Hemost 2008;34:612-34.
12. Mismetti P, Laporte S. New oral antithrombotics: a need for laboratory monitoring. For. J Thromb Haemost 2010;8:621-6.
13. Tripodi A, van den Besselaar A. Laboratory monitoring of anti-coagulation: where do we stand? Semin Thromb Hemost 2009; 35:34-41.
14. Lippi G, Franchini M, Targher G. Rivaroxaban for thrombo-prophylaxis. N Engl J Med 2008;359:2174.
15. Harenberg J, Wehling M. Current and future prospects for anti-coagulant therapy: inhibitors of factor Xa and factor IIa. Semin Thromb Hemost 2008;34:39-57. (Pubitemid 351640881)
16. Sobieraj-Teague M, O'Donnell M, Eikelboom J. New antico-agulants for atrial fibrillation. Semin Thromb Hemost 2009;35: 515-24.
17. Levi M, Hobbs FD, Jacobson AK, Pisters R, Prisco D, Ber-nardo A, et al. Improving antithrombotic management in patients with atrial fibrillation: current status and perspectives. Semin Thromb Hemost 2009;35:527-42.
18. Harenberg J. New anticoagulants in atrial fibrillation. Semin Thromb Hemost 2009;35:574-85.
19. Fareed J, Hoppensteadt DA, Fareed D, Demir M, Wahi R, Clarke M, et al. Survival of heparins, oral anticoagulants, and aspirin after the year 2010. Semin Thromb Hemost 2008;34: 58-73. (Pubitemid 351640882)
20. Adams M. Assessment of thrombin generation: useful or hype? Semin Thromb Hemost 2009;35:104-10.