The course of neuropsychiatric symptoms in Dementia: A 3-year longitudinal study

Journal of the American Medical Directors Association

Volumn 16, Issue 5, 2015, Pages 380-387

  Brodaty, Henry ^a,b   Connors, Michael H ^a,b   Xu, Jing ^a,b   Woodward, Michael ^c   Ames, David ^d,e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c AUSTIN HOSPITAL   (Australia)

^d National Aging Research Institute   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Alzheimer's disease; Behavioral and psychological symptoms of dementia; Dementia; Longitudinal study; Neuropsychiatric inventory; Neuropsychiatric symptoms

Indexed keywords

ANTIDEPRESSANT AGENT; CHOLINESTERASE INHIBITOR; MEMANTINE; NEUROLEPTIC AGENT;

AGED; AGITATION; ALZHEIMER DISEASE; ANXIETY; APATHY; APPETITE; ARTICLE; AUSTRALIA; BEHAVIOR DISORDER; CLINICAL FEATURE; COGNITIVE DEFECT; DELUSION; DEPRESSION; DIFFUSE LEWY BODY DISEASE; DISEASE SEVERITY; EUPHORIA; FEMALE; FRONTOTEMPORAL DEMENTIA; HALLUCINATION; HUMAN; IRRITABILITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTIINFARCT DEMENTIA; NEUROPSYCHIATRY; PREVALENCE; SEX DIFFERENCE; CAUSALITY; COGNITION DISORDERS; COMORBIDITY; DELUSIONS; HALLUCINATIONS; MENTAL HEALTH; MIDDLE AGED; MOOD DISORDERS; RESTLESSNESS; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANXIETY; AUSTRALIA; CAUSALITY; COGNITION DISORDERS; COMORBIDITY; DELUSIONS; FEMALE; HALLUCINATIONS; HUMANS; IRRITABLE MOOD; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; MOOD DISORDERS; PREVALENCE; PSYCHOMOTOR AGITATION; SEVERITY OF ILLNESS INDEX;

EID: 84928698653     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2014.12.018     Document Type: Article

References (43)

1. Cerejeira J., Lagarto L., Mukaetova-Ladinska E. Behavioral and psychological symptoms of dementia. Front Neurol 2012, 3:1-21.
2. Leroi I., Lyketsos C.G. Neuropsychiatric aspects of dementia. Dementia 2010, 68-74. Hodder Arnold, London, UK. 4th ed. D. Ames, A. Burns, J. O'Brien (Eds.).
3. Black W., Almeida O.P. Asystematic review of the association between the behavioral and psychological symptoms of dementia and burden of care. Int Psychogeriatr 2004, 16:295-315.
4. Pinquart M., Sörensen S. Associations of stressors and uplifts of caregiving with caregiver burden and depressive mood: A meta-analysis. JGerontol B Psychol Sci Soc Sci 2003, 58:P112-P128.
5. Gaugler J.E., Yu F., Krichbaum K., Wyman J.F. Predictors of nursing home admission for persons with dementia. Med Care 2009, 47:191-198.
6. Brodaty H., Connors M.H., Xu J., et al. Predictors of institutionalization in dementia: A three-year longitudinal study. JAlzheimers Dis 2014, 40:221-226.
7. Cummings J.L. The neuropsychiatry of Alzheimer's disease and related dementias 2003, Martin Dunitz, London, UK.
8. Aalten P., de Vugt M.E., Jaspers N., et al. The course of neuropsychiatric symptoms in dementia. Part I: Findings from the two-year longitudinal Maasbed study. Int J Geriatr Psychiatry 2005, 20:523-530.
9. Selbæk G., Engedal K., Benth J.Š., Bergh S. The course of neuropsychiatric symptoms in nursing-home patients with dementia over a 53-month follow-up period. Int Psychogeriatr 2014, 26:81-91.
10. Bergh S., Engedal K., Røen I., Selbæk G. The course of neuropsychiatric symptoms in patients with dementia in Norwegian nursing homes. Int Psychogeriatr 2011, 23:1231-1239.
11. Serra L., Perri R., Fadda L., et al. Relationship between cognitive impairment and behavioural disturbances in Alzheimer's disease patients. Behav Neurol 2010, 23:123-130.
12. Selbæk G., Kirkevold Ø., Engedal K. The course of psychiatric and behavioral symptoms and the use of psychotropic medication in patients with dementia in Norwegian nursing homes-A 12-month follow-up study. Am J Geriatr Psychiatry 2008, 16:528-536.
13. Wetzels R.B., Zuidema S.U., de Jonghe J.F.M., et al. Course of neuropsychiatric symptoms in residents with dementia in nursing homes over 2-year period. Am J Geriatr Psychiatry 2010, 18:1054-1065.
14. Devanand D.P., Jacobs D.M., Tang M.X., et al. The course of psychopathologic features in mild to moderate Alzheimer disease. Arch Gen Psychiatry 1997, 54:257-263.
15. Devanand D.P. The interrelations between psychosis, behavioral disturbance, and depression in Alzheimer disease. Alzheimer Dis Assoc Disord 1999, 13:S3-S8.
16. Brodaty H., Woodward M., Boundy K., et al. Patients in Australian memory clinics: Baseline characteristics and predictors of decline at six months. Int Psychogeriatr 2011, 23:1086-1096.
17. Diagnostic and statistical manual of mental disorders 2000, American Psychiatric Association, American Psychiatric Association, Washington, DC. 4th ed, text rev. (DSM-IV-TR).
18. Winblad B., Palmer K., Kivipelto M., et al. Mild cognitive impairment-Beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. JIntern Med 2004, 256:240-246.
19. Neary D., Snowden J.S., Gustafson L., et al. Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology 1998, 51:1546-1554.
20. McKhann G., Drachman D., Folstein M., et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984, 34:939-944.
21. McKeith I.G., Galasko D., Kosaka K., et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996, 47:1113-1124.
22. Cummings J.L. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 1997, 48:S10-S16.
23. Morris J.C. The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology 1993, 43:2412-2414.
24. O'Bryant S.E., Waring S.C., Cullum M., et al. Staging dementia using clinical dementia rating scale sum of boxes scores: A Texas Alzheimer's research consortium study. Arch Neurol 2008, 65:1091-1095.
25. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res 1975, 12:189-198.
26. Hébert R., Carrier R., Bilodeau A. The Functional Autonomy Measurement System (SMAF): Description and validation of an instrument for the measurement of handicaps. Age Ageing 1988, 17:293-302.
27. Blom G. Statistical estimates and transformed beta variables 1958, John Wiley and Sons, New York, NY.
28. Bollen K.A., Curran P.J. Latent curve models: A structure equation perspective 2006, John Wiley and Sons, Hoboken, NJ.
29. Kim J.M., Lyons D., Shin I.S., Yoon J.S. Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: Are the different pharmacologic treatment strategies justifiable?. Hum Psychopharmacol 2003, 18:215-220.
30. Ballard C., Neill D., O'Brien J., et al. Anxiety, depression and psychosis in vascular dementia: Prevalence and associations. JAffect Disord 2000, 59:97-106.
31. Fuh J.L., Wang S.J., Cummings J.L. Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia. JNeurol Neurosurg Psychiatry 2005, 76:1337-1341.
32. Thompson C., Brodaty H., Trollor J., Sachdev P. Behavioral and psychological symptoms associated with dementia subtype and severity. Int Psychogeriatr 2010, 22:300-305.
33. Bathgate D., Snowden J.S., Varma A., et al. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia. Acta Neurol Scand 2001, 103:367-378.
34. Stavitsky K., Brickman A.M., Scarmeas N., et al. The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease. Arch Neurol 2006, 63:1450-1456.
35. Lövheim H., Sandman P.O., Karlsson S., Gustafson Y. Sex differences in the prevalence of behavioral and psychological symptoms of dementia. Int Psychogeriatr 2009, 21:469-475.
36. Zuidema S.U., de Jonghe J.F.M., Verhey F.R.J., Koopmans R.T.C.M. Environmental correlates of neuropsychiatric symptoms in nursing home patients with dementia. Int J Geriatr Psychiatry 2010, 25:14-22.
37. Savva G.M., Zaccai J., Matthews F.E., et al. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry 2009, 194:212-219.
38. Sinforiani E., Citterio A., Zucchella C., et al. Impact of gender differences on the outcome of Alzheimer's disease. Dement Geriatr Cogn Disord 2010, 30:147-154.
39. Banerjee S., Hellier J., Dewey M., et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 2011, 378:403-411.
40. Brodaty H. Antidepressant treatment in Alzheimer's disease. Lancet 2011, 378:375-376.
41. de Vries N.M., Staal J.B., van Ravensberg C.D., et al. Outcome instruments to measure frailty: A systematic review. Ageing Res Rev 2011, 10:104-114.
42. McKeith I., Cummings J. Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 2005, 4:735-742.
43. Brodaty H., Arasaratnam C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry 2012, 169:946-953.