CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 17, 2015, Pages 5461-5466

  Bernhard, Caroline A ^a   Ried, Christine ^a   Kochanek, Stefan ^b   Brocker, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Adenovirus; CD169+ macrophage; CD8 T cell; Cross presentation; Dendritic cell

Indexed keywords

BINDING PROTEIN; CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SIALOADHESIN; CD69 ANTIGEN; LECTIN; LEUKOCYTE ANTIGEN; T LYMPHOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; INFECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; ANIMAL; ANTIGEN PRESENTATION; CROSS REACTION; CYTOLOGY; IMMUNOLOGY; PHYSIOLOGY;

ADENOVIRIDAE; MUS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD8-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; LECTINS, C-TYPE; MICE;

EID: 84928685251     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1423356112     Document Type: Article

References (39)

1. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392(6673):245-252.
2. Bar-On L, Jung S (2010) Defining dendritic cells by conditional and constitutive cell ablation. Immunol Rev 234(1):76-89.
3. Ohnmacht C, et al. (2009) Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 206(3):549-559.
4. Joffre OP, Segura E, Savina A, Amigorena S (2012) Cross-presentation by dendritic cells. Nat Rev Immunol 12(8):557-569.
5. Oehen S, et al. (2002) Marginal zone macrophages and immune responses against viruses. J Immunol 169(3):1453-1458.
6. Iannacone M, et al. (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465(7301):1079-1083.
7. Honke N, et al. (2012) Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol 13(1):51-57.
8. Junt T, Scandella E, Ludewig B (2008) Form follows function: Lymphoid tissue microarchitecture in antimicrobial immune defence. Nat Rev Immunol 8(10):764-775.
9. + dendritic cells in the generation of cytotoxic T cells. Proc Natl Acad Sci USA 107(1):216-221.
10. Probst HC, et al. (2005) Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol 141(3):398-404.
11. Meredith MM, et al. (2012) Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J ExpMed 209(6):1153-1165.
12. Asano K, et al. (2011) CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34(1):85-95.
13. Melief CJ (2003) Mini-review. Regulation of cytotoxic T lymphocyte responses by dendritic cells: Peaceful coexistence of cross-priming and direct priming? Eur J Immunol 33(10):2645-2654.
14. Zinkernagel RM (2002) On cross-priming of MHC class I-specific CTL: Rule or exception? Eur J Immunol 32(9):2385-2392.
15. + T cell responses. Front Immunol 5:30.
16. Di Paolo NC, et al. (2009) Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31(1):110-121.
17. + T cell immunity. Nat Med 16(3):339-345.
18. Hudrisier D, Oldstone MB, Gairin JE (1997) The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic T cell epitope that is restricted by both H-2D(b) and H-2K(b) molecules. Virology 234(1):62-73.
19. Achour A, et al. (2002) A structural basis for LCMV immune evasion: Subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure analyses. Immunity 17(6):757-768.
20. + T-cell response to lymphocytic choriomeningitis virus involves the L antigen: Uncovering new tricks for an old virus. J Virol 81(10):4928-4940.
21. Gallimore A, et al. (1998) Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med 187(9):1383-1393.
22. Basler M, Youhnovski N, Van Den Broek M, Przybylski M, Groettrup M (2004) Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J Immunol 173(6):3925-3934.
23. Chen W, Khilko S, Fecondo J, Margulies DH, McCluskey J (1994) Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J Exp Med 180(4):1471-1483.
24. Skolnick J, Milik M, Kolinski A (1999) Prediction of relative binding motifs of biologically active peptides and peptide mimetics. US Patent 5933819.
25. Lipford GB, Hoffman M, Wagner H, Heeg K (1993) Primary in vivo responses to ovalbumin: Probing the predictive value of the Kb binding motif. J Immunol 150(4):1212-1222.
26. Kurts C, Cannarile M, Klebba I, Brocker T (2001) Dendritic cells are sufficient to crosspresent self-antigens to CD8 T cells in vivo. J Immunol 166(3):1439-1442.
27. Gruber A, et al. (2010) Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis. Eur J Immunol 40(4):966-975.
28. + T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell. Eur J Immunol 42(9):2290-2304.
29. Torti N, Walton SM, Brocker T, Rülicke T, Oxenius A (2011) Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog 7(10):e1002313.
30. Honke N, et al. (2013) Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog 9(10):e1003650.
31. + T cells by exogenous cell-associated antigens. Immunity 17(2):211-220.
32. Chtanova T, et al. (2009) Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity 31(2):342-355.
33. Kurts C, Miller JF, Subramaniam RM, Carbone FR, Heath WR (1998) Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med 188(2):409-414.
34. Liu L, Chavan R, Feinberg MB (2008) Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo. BMC Immunol 9:15.
35. Wolkers MC, Brouwenstijn N, Bakker AH, Toebes M, Schumacher TN (2004) Antigen bias in T cell cross-priming. Science 304(5675):1314-1317.
36. Ochsenbein AF, et al. (2001) Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 411(6841):1058-1064.
37. Freigang S, et al. (2007) A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses. Proc Natl Acad Sci USA 104(33):13426-13431.
38. Pavelic V, Matter MS, Mumprecht S, Breyer I, Ochsenbein AF (2009) CTL induction by cross-priming is restricted to immunodominant epitopes. Eur J Immunol 39(3): 704-716.
39. + T cell tolerance in vivo. Immunity 28(4):521-532.