Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles

Nanoscale Research Letters

Volumn 9, Issue 1, 2014, Pages

  Dian, Linghui ^a,b   Yu, Enjiang ^a   Chen, Xiaona ^b   Wen, Xinguo ^b   Zhang, Zhengzan ^b   Qin, Lingzhen ^b   Wang, Qingqing ^b   Li, Ge ^b   Wu, Chuanbin ^b  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Oral bioavailability; Polymeric micelles; Quercetin; Soluplus

Indexed keywords

BIOCHEMISTRY; FLAVONOIDS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FUNCTIONAL POLYMERS; HYDROGEN BONDS; MICELLES; PHENOLS;

ENCAPSULATION EFFICIENCY; INTERMOLECULAR HYDROGEN BONDING; NARROW SIZE DISTRIBUTIONS; ORAL BIOAVAILABILITIES; POLYMERIC MICELLE; POORLY WATER-SOLUBLE DRUGS; QUERCETIN; SOLUPLUS;

DRUG DELIVERY;

CANIS FAMILIARIS;

EID: 84928661011     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/1556-276X-9-684     Document Type: Article

References (41)

1. Lavellea EC, Sharif S, Thomas NW, Holland J, Davis SS: The importance of gastrointestinal uptake of particles in the design of oral delivery systems.Adv Drug Delivery Rev 1995, 18:5–22. 10.1016/0169-409X(95)00048-C
2. Deshpande AA, Rhodes CT, Shah NH, Malick AW: Controlled-release drug delivery systems for prolonged gastric residence: an overview.Drug Dev Ind Pharm 1996, 22:531–539. 10.3109/03639049609108355
3. Dian LH, Yang ZW, Li F, Wang ZH, Pan X, Peng XS, Huang XT, Guo ZF, Quan GL, Shi X, Chen B, Li G, Wu CB: Cubic phase nanoparticles for sustained release of ibuprofen: Formulation, characterization and enhanced bioavailability study.Int J Nanomedicine 2013, 8:845–854.
4. Johnston APR, Such GK, Ng SL, Caruso F: Challenges facing colloidal delivery systems: FROM synthesis to the clinic.Curr Opin Colloid Interface Sci 2011, 16:171–181. 10.1016/j.cocis.2010.11.003
5. Bromberg L: Polymeric micelles in oral chemotherapy.J Control Release 2008, 128:89–112. 10.1016/j.jconrel.2008.02.004
6. Blanchette J, Peppas NA: Oral chemotherapeutic delivery design and cellular response.Annals Biomed Eng 2005, 33:142–149. 10.1007/s10439-005-8973-8
7. Dufresne MH, Garrec DL, Sant V, Leroux JC, Rangeret M: Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery.Int J Pharm 2004, 277:81–90. 10.1016/j.ijpharm.2003.07.014
8. Yamamoto Y, Xnagasaki Y, Kato Y, Sugiyama Y, Kataoka K: Long-circulating poly (ethylene glycol)-poly (L, D-lactide) block copolymer micelles with modulated surface charge.J Control Release 2001, 77:27–38. 10.1016/S0168-3659(01)00451-5
9. Kataoka K, Harada A, Nagasaki Y: Block copolymer micelles for drug delivery: design, characterization and biological significance.Adv Drug Delivery Rev 2012, 64:37–48.
10. Jin Y, Song Y, Zhu X, Zhou D, Chen CH, Zhang ZR, Yuan H: Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport.Biomaterials 2012, 33:1573–1582. 10.1016/j.biomaterials.2011.10.075
11. Yao HJ, Ju RJ, Wang XX, Zhang Y, Li RJ, Yu Y, Zhang L, Lu WL: The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery.Biomaterials 2011, 32:3285–3302. 10.1016/j.biomaterials.2011.01.038
12. Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL: The flavonoid quercetin in disease prevention and therapy: facts and fancies.Biochem Pharmacol 2012, 83:6–15. 10.1016/j.bcp.2011.08.010
13. Scambia G, Panici PB, Ranelletti FO, Ferrandina G, De-Vincenzo R, Piantelli M, Masciullo V, Bonanno G, Isola G, Mancuso S: Quercetin enhances transforming growth factor β1, secretion by human ovarian cancer cells.Int J Cancer 1994, 57:211–215. 10.1002/ijc.2910570214
14. Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, Yoo YD, Kim TW, Lee YS, Lee SJ: Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.Int J Oncol 2001, 19:837–844.
15. Yang JH, Hsia TC, Kuo HM, Chao PD, Chou CC, Wei YH, Chung JG: Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis.Drug Metab Dispos 2006, 34:296–304.
16. Kuo SM: Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells.Cancer Lett 1996, 110:41–48. 10.1016/S0304-3835(96)04458-8
17. Jakubowicz-Gil J, Paduch R, Piersiak T, Gowniak K, Gawron A, Kandefer-Szerszeń M: The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells.Biochem Pharmacol 2005, 69:1343–1350. 10.1016/j.bcp.2005.01.022
18. Asaum J, Matsuzaki H, Kawasak S, Kuroda M, Takeda Y, Kishi K, Hiraki Y: Effects of quercetin on the cell growth and the intracellular accumulation and retention of adriamycin.Anticancer Res 2000, 20:2477–2483.
19. Čipák L, Rauko P, Miadoková E, Cipáková I, Novotný L: Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells.Leuk Res 2003, 27:65–72. 10.1016/S0145-2126(02)00063-2
20. Chan MM, Fong D, Soprano KJ, Holmes WF, Heverling H: Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents.J Cell Physiol 2003, 194:63–70. 10.1002/jcp.10186
21. Pralhad T, Rajendrakumar K: Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis.J Pharm Biomed Anal 2004, 34:333–339. 10.1016/S0731-7085(03)00529-6
22. Ratnam DV, Ankola DD, Bhardwaj V, Sahana DK, Kumar MN: Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective.J Control Release 2006, 113:189–207. 10.1016/j.jconrel.2006.04.015
23. Hamaguchi T, Matsumura Y, Suzuki M, Shimizu K, Goda R, Nakamura I: NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel.Brit J Cancer 2005, 92:1240–1246. 10.1038/sj.bjc.6602479
24. Nakanishi T, Fukushima S, Okamoto K, Suzuki M, Matsumura Y, Yokoyama M, Okano T, Sakurai Y, Kataoka K: Development of the polymer micelle carrier system for doxorubicin.J Control Release 2001, 74:295–302. 10.1016/S0168-3659(01)00341-8
25. Gao X, Wang BL, Wei XW, Men K, Zheng FG: Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer.Nanoscale 2012, 4:7021–7030. 10.1039/c2nr32181e
26. Ali S, Langley N, Djuric D, Kolter K: Eye on excipients. http://www.kollidon.com/Documents/ENP/Articles/EN/EyeOnExcipients_1010TC.pdf
27. Kim Y, Dalhaimer P, Christian DA, Discher DE: Polymeric worm micelles as nano-carriers for drug delivery.Nanotechnology 2005,2005(16):1–8.
28. Zeng N, Gao X, Hu Q, Song QX, Xia HM, Liu ZY, Gu GZ, Jiang MY, Pang ZQ, Chen HZ, Chen J, Fang L: Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption.Int J Nanomedicine 2012, 7:3703–3718.
29. Panwar P, Pandey B, Lakhera P, Singh KP: Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes.Int J Nanomedicine 2010, 5:101–108.
30. Jain S, Mittal A, Jain AK, Mahajan RR, Sing D: Cyclosporin A loaded PLGA nanoparticle: preparation, optimization, in vitro characterization and stability studies.Curr Nanoscience 2010, 6:422–431. 10.2174/157341310791658937
31. Abdelwahed W, Degobert G, Fessi H: Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage.Eur J Pharm Biopharm 2006, 63:87–94. 10.1016/j.ejpb.2006.01.015
32. Amit KJ, Nitin KS, Chandraiah G, Raman PS, Sanyog J: The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen.Biomaterials 2011, 32:503–515. 10.1016/j.biomaterials.2010.09.037
33. Li HL, Zhao XB, Ma YK, Zhai GX, Li LB: Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.J Control Release 2009, 133:238–244. 10.1016/j.jconrel.2008.10.002
34. Feng SS, Mei L, Anitha P, Gan CW, Zhou W: Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of docetaxe.Biomaterials 2009, 30:3297–3306. 10.1016/j.biomaterials.2009.02.045
35. Wu TH, Yen FL, Lin LT, Tsai TR, Lin CC, Cham TM: Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles.Int J Pharm 2008, 46:160–168.
36. Xie JX, Chang JB, Wang XM: Infrared spectroscopy application in organic chemistry and drug chemistry. Beijing: Science Press; 2001.
37. Lauro MR, Torre ML, Maggi L, De Simone F, Conte U, Aquino RP: Fast-and slow release tablets for oral administration of flavonoids: rutin and quercetin.Drug Dev Ind Pharm 2002, 28:371–379. 10.1081/DDC-120002998
38. Derakhshandeh K, Soheili M, Dadashzadeh S, Saghiri R: Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients.Int J Nanomedicine 2010, 5:463–471.
39. Kataoka K, Matsumoto T, Yokoyama M, Okano T, Sakurai Y, Fukushima S, Okamoto K, Kwon GS: Doxorubicin-loaded poly-(ethylene glycol)-poly(B-benzyl-L-aspartate) copolymer micelles: Their pharmaceutical characteristics and biological significance.J Control Release 2000, 64:143–153. 10.1016/S0168-3659(99)00133-9
40. Erlund L, Kosonen T, Alfthan G, Menp J, Perttunen K, Kenraali J: Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.Eur J Clin Pharmacol 2000, 56:545–553. 10.1007/s002280000197
41. Khaled KA, El-Sayed YM, Al-Hadiya BM: Disposition of the flavonoid quercetin in rats after single intravenous and oral doses.Drug Dev Ind Phann 2003, 29:397–403. 10.1081/DDC-120018375