-
1
-
-
0022189558
-
Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
-
Anderson KV, Bokla L, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 1985;42:791-798.
-
(1985)
Cell
, vol.42
, pp. 791-798
-
-
Anderson, K.V.1
Bokla, L.2
Nusslein-Volhard, C.3
-
2
-
-
74549178528
-
Myocardial ischemia/reperfusion injury is mediated by leukocytic Toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody
-
Arslan F, Smeets MB, O’Neill LA et al. Myocardial ischemia/reperfusion injury is mediated by leukocytic Toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation 2010;121:80-90.
-
(2010)
Circulation
, vol.121
, pp. 80-90
-
-
Arslan, F.1
Smeets, M.B.2
O’Neill, L.A.3
-
3
-
-
59349084695
-
Sensitization and tolerization to brain antigens in stroke
-
Becker KJ. Sensitization and tolerization to brain antigens in stroke. Neuroscience 2009;158:1090-1097.
-
(2009)
Neuroscience
, vol.158
, pp. 1090-1097
-
-
Becker, K.J.1
-
4
-
-
79957938359
-
Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values
-
Brea D, Blanco M, Ramos-Cabrer P, Moldes O, Arias S, Perez-Mato M, Leira R, Sobrino T, Castillo J. Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values. J Cereb Blood Flow Metab 2011;31:1424-1431.
-
(2011)
J Cereb Blood Flow Metab
, vol.31
, pp. 1424-1431
-
-
Brea, D.1
Blanco, M.2
Ramos-Cabrer, P.3
Moldes, O.4
Arias, S.5
Perez-Mato, M.6
Leira, R.7
Sobrino, T.8
Castillo, J.9
-
5
-
-
43749110906
-
CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
-
Bulloch K, Miller MM, Gal-Toth J et al. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol 2008;508:687-710.
-
(2008)
J Comp Neurol
, vol.508
, pp. 687-710
-
-
Bulloch, K.1
Miller, M.M.2
Gal-Toth, J.3
-
6
-
-
33845871980
-
Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice
-
Cao CX, Yang QW, Lv FL, Cui J, Fu HB, Wang JZ. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 2007;353:509-514.
-
(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 509-514
-
-
Cao, C.X.1
Yang, Q.W.2
Lv, F.L.3
Cui, J.4
Fu, H.B.5
Wang, J.Z.6
-
7
-
-
41149112041
-
Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke
-
Caso JR, Pradillo JM, Hurtado O, Leza JC, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 2008;39:1314-1320.
-
(2008)
Stroke
, vol.39
, pp. 1314-1320
-
-
Caso, J.R.1
Pradillo, J.M.2
Hurtado, O.3
Leza, J.C.4
Moro, M.A.5
Lizasoain, I.6
-
8
-
-
34247545017
-
Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
-
Caso JR, Pradillo JM, Hurtado O, Lorenzo P, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 2007;115:1599-1608.
-
(2007)
Circulation
, vol.115
, pp. 1599-1608
-
-
Caso, J.R.1
Pradillo, J.M.2
Hurtado, O.3
Lorenzo, P.4
Moro, M.A.5
Lizasoain, I.6
-
9
-
-
84863726869
-
The immunology of acute stroke
-
Chamorro A, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R. The immunology of acute stroke. Nat Rev Neurol 2012;8:401-410.
-
(2012)
Nat Rev Neurol
, vol.8
, pp. 401-410
-
-
Chamorro, A.1
Meisel, A.2
Planas, A.M.3
Urra, X.4
Van De Beek, D.5
Veltkamp, R.6
-
10
-
-
33947515643
-
Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression
-
Chamorro A, Urra X, Planas AM. Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression. Stroke 2007;38:1097-1103.
-
(2007)
Stroke
, vol.38
, pp. 1097-1103
-
-
Chamorro, A.1
Urra, X.2
Planas, A.M.3
-
11
-
-
84889251844
-
N2 neutrophils, novel players in brain inflammation after stroke. Modulation by the PPARγ agonist rosiglitazone
-
Cuartero MI, Ballesteros I, Moraga A, Nombela F, Vivancos J, Hamilton JA, Corbi A, Lizasoain I, Moro MA. N2 neutrophils, novel players in brain inflammation after stroke. Modulation by the PPARγ agonist rosiglitazone. Stroke 2013;44:3498-3508.
-
(2013)
Stroke
, vol.44
, pp. 3498-3508
-
-
Cuartero, M.I.1
Ballesteros, I.2
Moraga, A.3
Nombela, F.4
Vivancos, J.5
Hamilton, J.A.6
Corbi, A.7
Lizasoain, I.8
Moro, M.A.9
-
12
-
-
78149253585
-
Acute anti-inflammatory approaches to ischemic stroke
-
del Zoppo GJ. Acute anti-inflammatory approaches to ischemic stroke. Ann N Y Acad Sci 2010;1207:143-148.
-
(2010)
Ann N Y Acad Sci
, vol.1207
, pp. 143-148
-
-
Del Zoppo, G.J.1
-
13
-
-
85027951898
-
Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice
-
Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J, O’Brien KD, Chait A. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2012;32:1596-1604.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 1596-1604
-
-
Ding, Y.1
Subramanian, S.2
Montes, V.N.3
Goodspeed, L.4
Wang, S.5
Han, C.6
Teresa, A.S.7
Kim, J.8
O’Brien, K.D.9
Chait, A.10
-
14
-
-
33847099936
-
Astrocytes are active players in cerebral innate immunity
-
Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007;28:138-145.
-
(2007)
Trends Immunol
, vol.28
, pp. 138-145
-
-
Farina, C.1
Aloisi, F.2
Meinl, E.3
-
15
-
-
0038202204
-
Evolutionary relationships, but functional differences, between the Drosophila and human Toll-like receptor families
-
Gangloff M, Webez AN, Gibbard RJ, Gay NJ. Evolutionary relationships, but functional differences, between the Drosophila and human Toll-like receptor families. Biochem Soc Trans 2003;31:659-663.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 659-663
-
-
Gangloff, M.1
Webez, A.N.2
Gibbard, R.J.3
Gay, N.J.4
-
16
-
-
0024299087
-
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
-
Hashimoto C, Hudson KL, Anderson KV. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 1988;52:269-279.
-
(1988)
Cell
, vol.52
, pp. 269-279
-
-
Hashimoto, C.1
Hudson, K.L.2
Anderson, K.V.3
-
17
-
-
0034671891
-
Functional requirement for class I MHC in CNS development and plasticity
-
Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ. Functional requirement for class I MHC in CNS development and plasticity. Science 2000;290:2155-2159.
-
(2000)
Science
, vol.290
, pp. 2155-2159
-
-
Huh, G.S.1
Boulanger, L.M.2
Du, H.3
Riquelme, P.A.4
Brotz, T.M.5
Shatz, C.J.6
-
18
-
-
35448947910
-
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
-
Hurn PD, Subramanian S, Parker SM, Afentoulis ME, Kaler LJ, Vandenbark AA, Offner H. T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab 2007;27:1798-1805.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 1798-1805
-
-
Hurn, P.D.1
Subramanian, S.2
Parker, S.M.3
Afentoulis, M.E.4
Kaler, L.J.5
Vandenbark, A.A.6
Offner, H.7
-
19
-
-
77957858212
-
Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
-
Hyakkoku K, Hamanaka J, Tsuruma K, Shimazawa M, Tanaka H, Uematsu S, Akira S, Inagaki N, Nagai H, Hara H. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience 2010;171:258-267.
-
(2010)
Neuroscience
, vol.171
, pp. 258-267
-
-
Hyakkoku, K.1
Hamanaka, J.2
Tsuruma, K.3
Shimazawa, M.4
Tanaka, H.5
Uematsu, S.6
Akira, S.7
Inagaki, N.8
Nagai, H.9
Hara, H.10
-
20
-
-
79960141471
-
The immunology of stroke: From mechanisms to translation
-
Iadecola C, Anrather J. The immunology of stroke: From mechanisms to translation. Nat Med 2011;17:796-808.
-
(2011)
Nat Med
, vol.17
, pp. 796-808
-
-
Iadecola, C.1
Anrather, J.2
-
21
-
-
45849105153
-
Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer’s disease
-
Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi K. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer’s disease. J Neuroinflammation 2008;5:23.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 23
-
-
Jin, J.J.1
Kim, H.D.2
Maxwell, J.A.3
Li, L.4
Fukuchi, K.5
-
22
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol 2010;11:373-384.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
23
-
-
84876713102
-
Toll-like receptors: Sensor molecules for detecting damage to the nervous system
-
Lee H, Lee S, Cho IH, Lee SJ. Toll-like receptors: Sensor molecules for detecting damage to the nervous system. Curr Protein Pept Sci 2013;14:33-42.
-
(2013)
Curr Protein Pept Sci
, vol.14
, pp. 33-42
-
-
Lee, H.1
Lee, S.2
Cho, I.H.3
Lee, S.J.4
-
24
-
-
84877577557
-
Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases
-
Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacol Ther 2013;138:441-451.
-
(2013)
Pharmacol Ther
, vol.138
, pp. 441-451
-
-
Li, J.1
Wang, X.2
Zhang, F.3
Yin, H.4
-
25
-
-
59649123881
-
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
-
Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 2009;15:192-199.
-
(2009)
Nat Med
, vol.15
, pp. 192-199
-
-
Liesz, A.1
Suri-Payer, E.2
Veltkamp, C.3
Doerr, H.4
Sommer, C.5
Rivest, S.6
Giese, T.7
Veltkamp, R.8
-
26
-
-
78651010946
-
Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye
-
Medawar PB. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 1948;29:58-69.
-
(1948)
Br J Exp Pathol
, vol.29
, pp. 58-69
-
-
Medawar, P.B.1
-
27
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.3
-
28
-
-
27944503933
-
Central nervous system injury-induced immune deficiency syndrome
-
Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005;6:775-786.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 775-786
-
-
Meisel, C.1
Schwab, J.M.2
Prass, K.3
Meisel, A.4
Dirnagl, U.5
-
29
-
-
0033049143
-
Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
-
Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999;5:49-55.
-
(1999)
Nat Med
, vol.5
, pp. 49-55
-
-
Moalem, G.1
Leibowitz-Amit, R.2
Yoles, E.3
Mor, F.4
Cohen, I.R.5
Schwartz, M.6
-
30
-
-
84912081101
-
Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cererbral ischemia
-
under review
-
Moraga A, Pradillo JM, Cuartero MI, Hernandez-Jimenez M, Oses M, Moro MA, Lizasoain I. Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cererbral ischemia. FASEB J. 2014, under review.
-
(2014)
FASEB J.
-
-
Moraga, A.1
Pradillo, J.M.2
Cuartero, M.I.3
Hernandez-Jimenez, M.4
Oses, M.5
Moro, M.A.6
Lizasoain, I.7
-
31
-
-
61849108779
-
Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning
-
Pradillo JM, Fernandez-Lopez D, Garcia-Yebenes I, Sobrado M, Hurtado O, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning. J Neurochem 2009;109:287-294.
-
(2009)
J Neurochem
, vol.109
, pp. 287-294
-
-
Pradillo, J.M.1
Fernandez-Lopez, D.2
Garcia-Yebenes, I.3
Sobrado, M.4
Hurtado, O.5
Moro, M.A.6
Lizasoain, I.7
-
32
-
-
0042886941
-
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
-
Prass K, Meisel C, Hoflich C et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003;198:725-736.
-
(2003)
J Exp Med
, vol.198
, pp. 725-736
-
-
Prass, K.1
Meisel, C.2
Hoflich, C.3
-
33
-
-
10444278132
-
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
-
Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 2004;50:3856-3865.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3856-3865
-
-
Radstake, T.R.1
Roelofs, M.F.2
Jenniskens, Y.M.3
Oppers-Walgreen, B.4
Van Riel, P.L.5
Barrera, P.6
Joosten, L.A.7
Van Den Berg, W.B.8
-
34
-
-
34548358816
-
Toll-like receptors modulate adult hippocampal neurogenesis
-
Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 2007;9:1081-1088.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1081-1088
-
-
Rolls, A.1
Shechter, R.2
London, A.3
Ziv, Y.4
Ronen, A.5
Levy, R.6
Schwartz, M.7
-
35
-
-
7644232937
-
Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice
-
Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP, Stenzel-Poore MP. Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke 2004;35:2576-2581.
-
(2004)
Stroke
, vol.35
, pp. 2576-2581
-
-
Rosenzweig, H.L.1
Lessov, N.S.2
Henshall, D.C.3
Minami, M.4
Simon, R.P.5
Stenzel-Poore, M.P.6
-
36
-
-
84861999263
-
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
-
Shichita T, Hasegawa E, Kimura A et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med 2012;18:911-917.
-
(2012)
Nat Med
, vol.18
, pp. 911-917
-
-
Shichita, T.1
Hasegawa, E.2
Kimura, A.3
-
37
-
-
36849076770
-
The classical complement cascade mediates CNS synapse elimination
-
Stevens B, Allen NJ, Vazquez LE et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007;131:1164-1178.
-
(2007)
Cell
, vol.131
, pp. 1164-1178
-
-
Stevens, B.1
Allen, N.J.2
Vazquez, L.E.3
-
38
-
-
35348860696
-
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
-
Tang SC, Arumugam TV, Xu X et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 2007;104:13798-13803.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13798-13803
-
-
Tang, S.C.1
Arumugam, T.V.2
Xu, X.3
-
39
-
-
65249138162
-
Monocytes are major players in the prognosis and risk of infection after acute stroke
-
Urra X, Cervera A, Obach V, Climent N, Planas AM, Chamorro A. Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke 2009;40:1262-1268.
-
(2009)
Stroke
, vol.40
, pp. 1262-1268
-
-
Urra, X.1
Cervera, A.2
Obach, V.3
Climent, N.4
Planas, A.M.5
Chamorro, A.6
-
40
-
-
50249102689
-
Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction
-
Yang QW, Li JC, Lu FL, Wen AQ, Xiang J, Zhang LL, Huang ZY, Wang JZ. Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab 2008;28:1588-1596.
-
(2008)
J Cereb Blood Flow Metab
, vol.28
, pp. 1588-1596
-
-
Yang, Q.W.1
Li, J.C.2
Lu, F.L.3
Wen, A.Q.4
Xiang, J.5
Zhang, L.L.6
Huang, Z.Y.7
Wang, J.Z.8
-
41
-
-
79551627378
-
HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
-
Yang QW, Lu FL, Zhou Y, Wang L, Zhong Q, Lin S, Xiang J, Li JC, Fang CQ, Wang JZ. HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab 2011;31:593-605.
-
(2011)
J Cereb Blood Flow Metab
, vol.31
, pp. 593-605
-
-
Yang, Q.W.1
Lu, F.L.2
Zhou, Y.3
Wang, L.4
Zhong, Q.5
Lin, S.6
Xiang, J.7
Li, J.C.8
Fang, C.Q.9
Wang, J.Z.10
|