-
1
-
-
40649102666
-
Recombinant human activated protein C: Current insights into its mechanism of action
-
M. Levi, and T. van der Poll Recombinant human activated protein C: current insights into its mechanism of action Crit Care 11 2007 S3
-
(2007)
Crit Care
, vol.11
, pp. S3
-
-
Levi, M.1
Van Der Poll, T.2
-
2
-
-
27144469582
-
New insights into the protein C pathway: Potential implications for the biological activities of drotrecogin alfa (activated)
-
W.L. Macias, S.B. Yan, M.D. Williams, S.L. Um, G.E. Sandusky, and D.W. Ballard New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated) Crit Care 9 2005 S38 S45
-
(2005)
Crit Care
, vol.9
, pp. S38-S45
-
-
MacIas, W.L.1
Yan, S.B.2
Williams, M.D.3
Um, S.L.4
Sandusky, G.E.5
Ballard, D.W.6
-
3
-
-
84862906006
-
Protein C anticoagulant and cytoprotective pathways
-
J.H. Griffin, B.V. Zlokovic, and L.O. Mosnier Protein C anticoagulant and cytoprotective pathways Int J Hematol 95 2012 333 345
-
(2012)
Int J Hematol
, vol.95
, pp. 333-345
-
-
Griffin, J.H.1
Zlokovic, B.V.2
Mosnier, L.O.3
-
4
-
-
84880617084
-
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway
-
E.A. Bouwens, F. Stavenuiter, and L.O. Mosnier Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway J Thromb Haemost 11 2013 242 253
-
(2013)
J Thromb Haemost
, vol.11
, pp. 242-253
-
-
Bouwens, E.A.1
Stavenuiter, F.2
Mosnier, L.O.3
-
5
-
-
79960232160
-
Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis
-
C.J. Hemmer, M. Löbermann, M. Unverricht, A. Vogt, R. Krause, and E.C. Reisinger Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis Trop Med Int Health 16 2011 906 913
-
(2011)
Trop Med Int Health
, vol.16
, pp. 906-913
-
-
Hemmer, C.J.1
Löbermann, M.2
Unverricht, M.3
Vogt, A.4
Krause, R.5
Reisinger, E.C.6
-
6
-
-
37549020378
-
Surviving sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
-
R.P. Dellinger, M.M. Levy, J.M. Carlet, J. Bion, M.M. Parker, and R. Jaeschke Surviving sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 Crit Care Med 36 2008 296 327
-
(2008)
Crit Care Med
, vol.36
, pp. 296-327
-
-
Dellinger, R.P.1
Levy, M.M.2
Carlet, J.M.3
Bion, J.4
Parker, M.M.5
Jaeschke, R.6
-
7
-
-
84861665800
-
Drotrecogin alfa (activated) in adults with septic shock
-
V.M. Ranieri, B.T. Thompson, P.S. Barie, J.F. Dhainaut, I.S. Douglas, and S. Finfer Drotrecogin alfa (activated) in adults with septic shock N Engl J Med 366 2012 2055 2064
-
(2012)
N Engl J Med
, vol.366
, pp. 2055-2064
-
-
Ranieri, V.M.1
Thompson, B.T.2
Barie, P.S.3
Dhainaut, J.F.4
Douglas, I.S.5
Finfer, S.6
-
8
-
-
84865278685
-
Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: A meta-analysis and metaregression
-
A.C. Kalil, and S.P. LaRosa Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression Lancet Infect Dis 12 2012 678 686
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 678-686
-
-
Kalil, A.C.1
Larosa, S.P.2
-
9
-
-
84868206959
-
Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock: A propensity-matched cohort study
-
E. Rimmer, A. Kumar, S. Doucette, J. Marshall, S. Dial, and D. Gurka Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock: a propensity-matched cohort study Crit Care Med 40 2012 2974 2981
-
(2012)
Crit Care Med
, vol.40
, pp. 2974-2981
-
-
Rimmer, E.1
Kumar, A.2
Doucette, S.3
Marshall, J.4
Dial, S.5
Gurka, D.6
-
11
-
-
0012461468
-
A comparative double-blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation
-
N. Aoki, T. Matsuda, H. Saito, K. Takatsuki, K. Okajima, and H. Takahashi A comparative double-blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation Int J Hematol 75 2002 540 547
-
(2002)
Int J Hematol
, vol.75
, pp. 540-547
-
-
Aoki, N.1
Matsuda, T.2
Saito, H.3
Takatsuki, K.4
Okajima, K.5
Takahashi, H.6
-
12
-
-
84903984892
-
Is the neutrophil a 'prima donna' in the procoagulant process during sepsis?
-
T. Iba, T. Miki, N. Hashiguchi, Y. Tabe, and I. Nagaoka Is the neutrophil a 'prima donna' in the procoagulant process during sepsis? Crit Care 18 2014 230
-
(2014)
Crit Care
, vol.18
, pp. 230
-
-
Iba, T.1
Miki, T.2
Hashiguchi, N.3
Tabe, Y.4
Nagaoka, I.5
-
13
-
-
0036481635
-
Factor Xa-inhibitor (DX-9065a) modulates the leukocyte-endothelial cell interaction in endotoxemic rat
-
T. Iba, A. Kidokoro, M. Fukunaga, S. Fuse, M. Suda, and S. Kunitada Factor Xa-inhibitor (DX-9065a) modulates the leukocyte-endothelial cell interaction in endotoxemic rat Shock 17 2002 159 162
-
(2002)
Shock
, vol.17
, pp. 159-162
-
-
Iba, T.1
Kidokoro, A.2
Fukunaga, M.3
Fuse, S.4
Suda, M.5
Kunitada, S.6
-
14
-
-
84928631703
-
Activated protein C suppresses the production of pro-inflammatory cytokines and the leukocyte-endothelial interaction in rat LPS model
-
T. Iba, T. Miki, N. Hashiguchi, Y. Tabe, and I. Nagaoka Activated protein C suppresses the production of pro-inflammatory cytokines and the leukocyte-endothelial interaction in rat LPS model J Jpn Soc Intensive Care Med 12 2005 191 195
-
(2005)
J Jpn Soc Intensive Care Med
, vol.12
, pp. 191-195
-
-
Iba, T.1
Miki, T.2
Hashiguchi, N.3
Tabe, Y.4
Nagaoka, I.5
-
16
-
-
33846432787
-
Novel cell death program leads to neutrophil extracellular traps
-
T.A. Fuchs, U. Abed, C. Goosmann, R. Hurwitz, I. Schulze, and V. Wahn Novel cell death program leads to neutrophil extracellular traps J Cell Biol 176 2007 231 241
-
(2007)
J Cell Biol
, vol.176
, pp. 231-241
-
-
Fuchs, T.A.1
Abed, U.2
Goosmann, C.3
Hurwitz, R.4
Schulze, I.5
Wahn, V.6
-
17
-
-
34147188469
-
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
-
S.R. Clark, A.C. Ma, S.A. Tavener, B. McDonald, Z. Goodarzi, and M.M. Kelly Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood Nat Med 13 2007 463 469
-
(2007)
Nat Med
, vol.13
, pp. 463-469
-
-
Clark, S.R.1
Ma, A.C.2
Tavener, S.A.3
McDonald, B.4
Goodarzi, Z.5
Kelly, M.M.6
-
18
-
-
80053354116
-
Histones induce rapid and profound thrombocytopenia in mice
-
T.A. Fuchs, A.A. Bhandari, and D.D. Wagner Histones induce rapid and profound thrombocytopenia in mice Blood 118 2011 3708 3714
-
(2011)
Blood
, vol.118
, pp. 3708-3714
-
-
Fuchs, T.A.1
Bhandari, A.A.2
Wagner, D.D.3
-
19
-
-
84866554641
-
Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis
-
K. Kambas, I. Mitroulis, E. Apostolidou, A. Girod, A. Chrysanthopoulou, and I. Pneumatikos Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis PLoS One 7 2012 e45427
-
(2012)
PLoS One
, vol.7
, pp. e45427
-
-
Kambas, K.1
Mitroulis, I.2
Apostolidou, E.3
Girod, A.4
Chrysanthopoulou, A.5
Pneumatikos, I.6
-
20
-
-
57349120511
-
Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases
-
B. Steppich, I. Seitz, G. Busch, A. Stein, and I. Ott Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases Thromb Haemost 100 2008 1068 1075
-
(2008)
Thromb Haemost
, vol.100
, pp. 1068-1075
-
-
Steppich, B.1
Seitz, I.2
Busch, G.3
Stein, A.4
Ott, I.5
-
21
-
-
13444303827
-
Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
-
T. Iba, A. Kidokoro, M. Fukunaga, K. Nagakari, A. Shirahama, and Y. Ida Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model Crit Care Med 33 2005 368 372
-
(2005)
Crit Care Med
, vol.33
, pp. 368-372
-
-
Iba, T.1
Kidokoro, A.2
Fukunaga, M.3
Nagakari, K.4
Shirahama, A.5
Ida, Y.6
-
22
-
-
0025297484
-
Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites
-
J.P. Miletich, and G.J. Broze Jr. Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites J Biol Chem 265 1990 11397 11404
-
(1990)
J Biol Chem
, vol.265
, pp. 11397-11404
-
-
Miletich, J.P.1
Broze, Jr.G.J.2
-
23
-
-
0029795615
-
Compound heterozygous protein C deficiency resulting in the presence of only the beta-form of protein C in plasma
-
P. Simioni, M. Kalafatis, D.S. Millar, S.C. Henderson, S. Luni, and D.N. Cooper Compound heterozygous protein C deficiency resulting in the presence of only the beta-form of protein C in plasma Blood 88 1996 2101 2108
-
(1996)
Blood
, vol.88
, pp. 2101-2108
-
-
Simioni, P.1
Kalafatis, M.2
Millar, D.S.3
Henderson, S.C.4
Luni, S.5
Cooper, D.N.6
-
24
-
-
34948866150
-
Endotoxemia and sepsis mortality reduction by nonanticoagulant-activated protein C
-
E.J. Kerschen, J.A. Fernandez, B.C. Cooley, X.V. Yang, R. Sood, and L.O. Mosnier Endotoxemia and sepsis mortality reduction by nonanticoagulant-activated protein C J Exp Med 204 2007 2439 2448
-
(2007)
J Exp Med
, vol.204
, pp. 2439-2448
-
-
Kerschen, E.J.1
Fernandez, J.A.2
Cooley, B.C.3
Yang, X.V.4
Sood, R.5
Mosnier, L.O.6
-
25
-
-
77953202368
-
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
-
C. Cao, Y. Gao, Y. Li, T.M. Antalis, F.J. Castellino, and L. Zhang The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b J Clin Invest 120 2010 1971 1980
-
(2010)
J Clin Invest
, vol.120
, pp. 1971-1980
-
-
Cao, C.1
Gao, Y.2
Li, Y.3
Antalis, T.M.4
Castellino, F.J.5
Zhang, L.6
-
26
-
-
84880824585
-
Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis)
-
L.M. Kager, M. Schouten, W.J. Wiersinga, J.D. de Boer, L.C. Lattenist, and J.J. Roelofs Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis) PLoS Negl Trop Dis 7 2013 e2306
-
(2013)
PLoS Negl Trop Dis
, vol.7
, pp. e2306
-
-
Kager, L.M.1
Schouten, M.2
Wiersinga, W.J.3
De Boer, J.D.4
Lattenist, L.C.5
Roelofs, J.J.6
-
27
-
-
0043240071
-
Expression and function of the endothelial protein C receptor in human neutrophils
-
D.H. Sturn, N.C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C.J. Wiedermann Expression and function of the endothelial protein C receptor in human neutrophils Blood 102 2003 1499 1505
-
(2003)
Blood
, vol.102
, pp. 1499-1505
-
-
Sturn, D.H.1
Kaneider, N.C.2
Feistritzer, C.3
Djanani, A.4
Fukudome, K.5
Wiedermann, C.J.6
-
28
-
-
65449167251
-
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration
-
G.F. Elphick, P.P. Sarangi, Y.M. Hyun, J.A. Hollenbaugh, A. Ayala, and W.L. Biffl Recombinant human activated protein C inhibits integrin-mediated neutrophil migration Blood 113 2009 4078 4085
-
(2009)
Blood
, vol.113
, pp. 4078-4085
-
-
Elphick, G.F.1
Sarangi, P.P.2
Hyun, Y.M.3
Hollenbaugh, J.A.4
Ayala, A.5
Biffl, W.L.6
-
29
-
-
10244229104
-
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
-
J.A. Nick, C.D. Coldren, M.W. Geraci, K.R. Poch, B.W. Fouty, and J. O'Brien Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis Blood 104 2004 3878 3885
-
(2004)
Blood
, vol.104
, pp. 3878-3885
-
-
Nick, J.A.1
Coldren, C.D.2
Geraci, M.W.3
Poch, K.R.4
Fouty, B.W.5
O'Brien, J.6
-
30
-
-
35948934636
-
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
-
B. Isermann, I.A. Vinnikov, T. Madhusudhan, S. Herzog, M. Kashif, and J. Blautzik Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis Nat Med 13 2007 1349 1358
-
(2007)
Nat Med
, vol.13
, pp. 1349-1358
-
-
Isermann, B.1
Vinnikov, I.A.2
Madhusudhan, T.3
Herzog, S.4
Kashif, M.5
Blautzik, J.6
-
31
-
-
84862815725
-
Activated protein C improves pial microcirculation in experimental endotoxemia in rats
-
J. Zhou, D. Pavlovic, J. Willecke, C. Friedel, S. Whynot, and O. Hung Activated protein C improves pial microcirculation in experimental endotoxemia in rats Microvasc Res 83 2012 276 280
-
(2012)
Microvasc Res
, vol.83
, pp. 276-280
-
-
Zhou, J.1
Pavlovic, D.2
Willecke, J.3
Friedel, C.4
Whynot, S.5
Hung, O.6
-
32
-
-
1842637573
-
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia
-
J.N. Hoffmann, B. Vollmar, M.W. Laschke, D. Inthorn, J. Fertmann, and F.W. Schildberg Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia Crit Care Med 32 2004 1011 1017
-
(2004)
Crit Care Med
, vol.32
, pp. 1011-1017
-
-
Hoffmann, J.N.1
Vollmar, B.2
Laschke, M.W.3
Inthorn, D.4
Fertmann, J.5
Schildberg, F.W.6
-
33
-
-
74949109112
-
Regulation of inflammation by the protein C system
-
H. Weiler Regulation of inflammation by the protein C system Crit Care Med 38 2010 S18 S25
-
(2010)
Crit Care Med
, vol.38
, pp. S18-S25
-
-
Weiler, H.1
-
34
-
-
79953162038
-
Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice
-
N. Bir, M. Lafargue, M. Howard, A. Golaerts, J. Roux, and M. Carles Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice Am J Respir Cell Mol Biol 45 2011 632 641
-
(2011)
Am J Respir Cell Mol Biol
, vol.45
, pp. 632-641
-
-
Bir, N.1
Lafargue, M.2
Howard, M.3
Golaerts, A.4
Roux, J.5
Carles, M.6
-
35
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
S.R. Coughlin Protease-activated receptors in hemostasis, thrombosis and vascular biology J Thromb Haemost 3 2005 1800 1814
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
36
-
-
84871556405
-
Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: A controlled laboratory study
-
M. Schouten, C. van't Veer, J.J. Roelofs, J.C. Meijers, M. Levi, and T. van der Poll Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study Crit Care 16 2012 R238
-
(2012)
Crit Care
, vol.16
, pp. R238
-
-
Schouten, M.1
Van'T Veer, C.2
Roelofs, J.J.3
Meijers, J.C.4
Levi, M.5
Van Der Poll, T.6
-
37
-
-
84898738420
-
The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases
-
M. Magna, and D.S. Pisetsky The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases Mol Med 20 2014 138 146
-
(2014)
Mol Med
, vol.20
, pp. 138-146
-
-
Magna, M.1
Pisetsky, D.S.2
-
38
-
-
84857591047
-
Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones
-
M. Saffarzadeh, C. Juenemann, M.A. Queisser, G. Lochnit, G. Barreto, and S.P. Galuska Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones PLoS One 7 2012 e32366
-
(2012)
PLoS One
, vol.7
, pp. e32366
-
-
Saffarzadeh, M.1
Juenemann, C.2
Queisser, M.A.3
Lochnit, G.4
Barreto, G.5
Galuska, S.P.6
-
39
-
-
70449107044
-
Extracellular histones are major mediators of death in sepsis
-
J. Xu, X. Zhang, R. Pelayo, M. Monestier, C.T. Ammollo, and F. Semeraro Extracellular histones are major mediators of death in sepsis Nat Med 15 2009 1318 1321
-
(2009)
Nat Med
, vol.15
, pp. 1318-1321
-
-
Xu, J.1
Zhang, X.2
Pelayo, R.3
Monestier, M.4
Ammollo, C.T.5
Semeraro, F.6
-
40
-
-
84863122657
-
Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction
-
M.R. Gillrie, K. Lee, D.C. Gowda, S.P. Davis, M. Monestier, and L. Cui Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction Am J Pathol 180 2012 1028 1039
-
(2012)
Am J Pathol
, vol.180
, pp. 1028-1039
-
-
Gillrie, M.R.1
Lee, K.2
Gowda, D.C.3
Davis, S.P.4
Monestier, M.5
Cui, L.6
|