메뉴 건너뛰기




Volumn 9, Issue 5, 2015, Pages 671-683

Management and diagnosis of fatty liver disease

Author keywords

fatty liver disease; NAFLD; NASH; review; steatohepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; EXENDIN 4; ICOSAPENTAENOIC ACID ETHYL ESTER; METFORMIN; OMEGA 3 FATTY ACID; PENTOXIFYLLINE; PIOGLITAZONE; PLACEBO; PROBUCOL; RESVERATROL; TETRAHYDROLIPSTATIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; URSODEOXYCHOLIC ACID;

EID: 84928563580     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2015.1003209     Document Type: Review
Times cited : (13)

References (158)
  • 1
    • 0028932680 scopus 로고
    • Two cases from the spectrum of nonalcoholic steatohepatitis
    • Abdelmalek M, Ludwig J, Lindor KD. Two cases from the spectrum of nonalcoholic steatohepatitis. J Clin Gastroenterol 1995; 20: 127-30
    • (1995) J Clin Gastroenterol , vol.20 , pp. 127-130
    • Abdelmalek, M.1    Ludwig, J.2    Lindor, K.D.3
  • 2
    • 33746383056 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Pathologic features and differential diagnosis
    • Brunt EM. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol 2005; 22: 300-38
    • (2005) Semin Diagn Pathol , vol.22 , pp. 300-338
    • Brunt, E.M.1
  • 3
    • 70349766580 scopus 로고    scopus 로고
    • Alcoholic and nonalcoholic fatty liver disease
    • Odze RD, Goldblum JR, editors 2nd edition. Elsevier Philadelphis, PA
    • Brunt EM, Tiniakos DG. Alcoholic and nonalcoholic fatty liver disease. In Odze RD, Goldblum JR, editors. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 2nd edition. Elsevier; Philadelphis, PA: 2009. p. 1007-14
    • (2009) Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas , pp. 1007-1014
    • Brunt, E.M.1    Tiniakos, D.G.2
  • 4
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis: mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-8
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3
  • 5
    • 79957449923 scopus 로고    scopus 로고
    • Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008
    • Younossi ZM, Stepanova M, Afendy M, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 2011; 9: 524-30
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 524-530
    • Younossi, Z.M.1    Stepanova, M.2    Afendy, M.3
  • 6
    • 70349770695 scopus 로고    scopus 로고
    • Epidemiology and natural history of non-alcoholic steatohepatitis
    • Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis 2009; 13: 511-31
    • (2009) Clin Liver Dis , vol.13 , pp. 511-531
    • Argo, C.K.1    Caldwell, S.H.2
  • 7
    • 84880245463 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in the United States: The Third National Health and Nutrition Examination Survey 1998-1994
    • Lazo M, Hernandez R, Eberhardt MS, et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1998-1994. Am J Epidemiol 2013; 178(1): 38-45
    • (2013) Am J Epidemiol , vol.178 , Issue.1 , pp. 38-45
    • Lazo, M.1    Hernandez, R.2    Eberhardt, M.S.3
  • 8
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study
    • Bedogni G, Miglioli L, Masutti F, et al. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005; 42: 44-52
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3
  • 9
    • 74349095236 scopus 로고    scopus 로고
    • Prevalence and factors associated with the presence of nonalcoholic fatty liver disease in an adult population in Spain
    • Caballerý'a L, Pera G, Auladell MA, et al. Prevalence and factors associated with the presence of nonalcoholic fatty liver disease in an adult population in Spain. Eur J Gastroenterol Hepatol 2010; 22: 24-32
    • (2010) Eur J Gastroenterol Hepatol , vol.22 , pp. 24-32
    • Caballería, L.1    Pera, G.2    Auladell, M.A.3
  • 10
    • 4043077045 scopus 로고    scopus 로고
    • Fatty liver: How frequent is it and why?
    • Bedogni G, Bellentani S. Fatty liver: how frequent is it and why?. Ann Hepatol 2004; 3: 63-5
    • (2004) Ann Hepatol , vol.3 , pp. 63-65
    • Bedogni, G.1    Bellentani, S.2
  • 11
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011; 140(1): 124-31
    • (2011) Gastroenterology , vol.140 , Issue.1 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 12
    • 0344393668 scopus 로고    scopus 로고
    • Increase in the prevalence of fatty liver in Japan over the past 12 years: Analysis of clinical background
    • Kojima SI, Watanabe N, Numata M, et al. Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background. J Gastroenterol 2003; 38: 954-61
    • (2003) J Gastroenterol , vol.38 , pp. 954-961
    • Kojima, S.I.1    Watanabe, N.2    Numata, M.3
  • 13
    • 35848932768 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease: Population based study
    • Amarapurkar D, Kamani P, Patel N, et al. Prevalence of non-alcoholic fatty liver disease: population based study. Ann Hepatol 2007; 6: 161-3
    • (2007) Ann Hepatol , vol.6 , pp. 161-163
    • Amarapurkar, D.1    Kamani, P.2    Patel, N.3
  • 14
    • 56949097660 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease in China
    • Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol 2009; 50: 204-10
    • (2009) J Hepatol , vol.50 , pp. 204-210
    • Fan, J.G.1    Farrell, G.C.2
  • 15
    • 33847002985 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis in donors for living donor liver transplantation
    • Yamamoto K, Takada Y, Fujimoto Y, et al. Nonalcoholic steatohepatitis in donors for living donor liver transplantation. Transplantation 2007; 83: 257-62
    • (2007) Transplantation , vol.83 , pp. 257-262
    • Yamamoto, K.1    Takada, Y.2    Fujimoto, Y.3
  • 16
    • 34347389654 scopus 로고    scopus 로고
    • Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: A review of 589 consecutive liver biopsies in a single center
    • Lee JY, Kim KM, Lee SG, et al. Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: a review of 589 consecutive liver biopsies in a single center. J Hepatol 2007; 47: 239-44
    • (2007) J Hepatol , vol.47 , pp. 239-244
    • Lee, J.Y.1    Kim, K.M.2    Lee, S.G.3
  • 17
    • 84904874834 scopus 로고    scopus 로고
    • Prevalence and predictors of nonalcoholic steatohepatitis in obese patients undergoing bariatric surgery: A department of defense experience
    • Reha JL, Lee S, Hofmann LJ. Prevalence and predictors of nonalcoholic steatohepatitis in obese patients undergoing bariatric surgery: a department of defense experience. Am Surg 2014; 80(6): 595-9
    • (2014) Am Surg , vol.80 , Issue.6 , pp. 595-599
    • Reha, J.L.1    Lee, S.2    Hofmann, L.J.3
  • 18
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40: 1387-95
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 19
    • 12844280471 scopus 로고    scopus 로고
    • Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease
    • Weston SR, Leyden W, Murphy R, et al. Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology 2005; 41: 372-9
    • (2005) Hepatology , vol.41 , pp. 372-379
    • Weston, S.R.1    Leyden, W.2    Murphy, R.3
  • 20
    • 84869498671 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in lean individuals in the United States
    • Younossi ZM, Stepanova M, Negro F, et al. Nonalcoholic fatty liver disease in lean individuals in the United States. Medicine (Baltimore) 2012; 91: 319-27
    • (2012) Medicine (Baltimore , vol.91 , pp. 319-327
    • Younossi, Z.M.1    Stepanova, M.2    Negro, F.3
  • 21
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 129: 113-21
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 22
    • 41949127014 scopus 로고    scopus 로고
    • Ethnicity and nonalcoholic fatty liver disease in an obesity clinic: The impact of triglycerides
    • Kallwitz ER, Kumar M, Aggarwal R, et al. Ethnicity and nonalcoholic fatty liver disease in an obesity clinic: The impact of triglycerides. Dig Dis Sci 2008; 53: 1358-63
    • (2008) Dig Dis Sci , vol.53 , pp. 1358-1363
    • Kallwitz, E.R.1    Kumar, M.2    Aggarwal, R.3
  • 23
    • 84892370481 scopus 로고    scopus 로고
    • Racial differences in nonalcoholic fatty liver disease in the U.S. Population
    • Schneider AL, Lazo M, Selvin E, Clark JM. Racial differences in nonalcoholic fatty liver disease in the U.S. population. Obesity (Silver Spring) 2014; 22: 292-9
    • (2014) Obesity (Silver Spring , vol.22 , pp. 292-299
    • Schneider, A.L.1    Lazo, M.2    Selvin, E.3    Clark, J.M.4
  • 24
    • 84875625146 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups
    • Smits MM, Ioannou GN, Boyko EJ, et al. Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups. J Gastroenterol Hepatol 2013; 28: 664-7
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 664-667
    • Smits, M.M.1    Ioannou, G.N.2    Boyko, E.J.3
  • 25
    • 84901398988 scopus 로고    scopus 로고
    • Gender and racial differences in nonalcoholic fatty liver disease
    • Fallon MB, Pan JJ. Gender and racial differences in nonalcoholic fatty liver disease. World J Hepatol 2014; 6(5): 274-83
    • (2014) World J Hepatol , vol.6 , Issue.5 , pp. 274-283
    • Fallon, M.B.1    Pan, J.J.2
  • 26
    • 0035196447 scopus 로고    scopus 로고
    • Total and regional body composition across age in healthy hispanic and white women of similar socioeconomic status
    • Casas YG, Schiller BC, DeSouza CA, et al. Total and regional body composition across age in healthy hispanic and white women of similar socioeconomic status. Am J Clin Nutr 2001; 73: 13-18
    • (2001) Am J Clin Nutr , vol.73 , pp. 13-18
    • Casas, Y.G.1    Schiller, B.C.2    Desouza, C.A.3
  • 27
    • 0036889453 scopus 로고    scopus 로고
    • Abdominal fat distribution and peripheral andhepatic insulin resistance in type 2 diabetes mellitus
    • Miyazaki Y, Glass L, Triplitt C, et al. Abdominal fat distribution and peripheral andhepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2002; 283: E1135-43
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , pp. E1135-E1143
    • Miyazaki, Y.1    Glass, L.2    Triplitt, C.3
  • 28
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
    • Van Der Poorten D, Milner KL, Hui J, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008; 48: 449-57
    • (2008) Hepatology , vol.48 , pp. 449-457
    • Van Der Poorten, D.1    Milner, K.L.2    Hui, J.3
  • 29
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-5
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 30
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011; 53: 1883-94:
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 31
    • 84902688337 scopus 로고    scopus 로고
    • Carriage of the PNPLA3 rs738409 C, G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
    • Liu YL, Patman GL, Leathart JB, et al. Carriage of the PNPLA3 rs738409 C, G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. J Hepatol 2014; 61(1): 75-81
    • (2014) J Hepatol , vol.61 , Issue.1 , pp. 75-81
    • Liu, Y.L.1    Patman, G.L.2    Leathart, J.B.3
  • 32
    • 63349086412 scopus 로고    scopus 로고
    • Ethnic differences in hepatic steatosis: An insulin resistance paradox
    • Guerrero R, Vega GL, Grundy SM, et al. Ethnic differences in hepatic steatosis: an insulin resistance paradox. Hepatology 2009; 49: 791-01
    • (2009) Hepatology , vol.49 , pp. 791-801
    • Guerrero, R.1    Vega, G.L.2    Grundy, S.M.3
  • 33
    • 67650496665 scopus 로고    scopus 로고
    • Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort
    • Wagenknecht LE, Scherzinger AL, Stamm ER, et al. Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort. Obesity (Silver Spring) 2009; 17: 1240-6
    • (2009) Obesity (Silver Spring , vol.17 , pp. 1240-1246
    • Wagenknecht, L.E.1    Scherzinger, A.L.2    Stamm, E.R.3
  • 34
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-23
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 35
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3
  • 36
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50(8): 1844-50
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 37
    • 0038392673 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver syndrome: A hepatic consequence of common metabolic diseases
    • Angelico F, Del Ben M, Conti R, et al. Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. J Gastroenterol Hepatol 2003; 18: 1115-17
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1115-1117
    • Angelico, F.1    Del Ben, M.2    Conti, R.3
  • 38
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms
    • Bugianesi E, Gastaldelli A, VanniE, et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005; 48(4): 634-42
    • (2005) Diabetologia , vol.48 , Issue.4 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vannie3
  • 39
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science 2011; 332(6037): 1519-23
    • (2011) Science , vol.332 , Issue.6037 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 40
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: A pathogenic paradox
    • Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008; 7(2): 95-6
    • (2008) Cell Metab , vol.7 , Issue.2 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 41
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50(8): 1844-50
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 42
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G Gambino R De Michieli F et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003 37 4 909-16
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3
  • 43
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346(16): 1221
    • (2002) N Engl J Med , vol.346 , Issue.16 , pp. 1221
    • Angulo, P.1
  • 44
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 2010; 52(2): 774-88
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 45
    • 0035084699 scopus 로고    scopus 로고
    • Nonacloholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonacloholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120(5): 1183
    • (2001) Gastroenterology , vol.120 , Issue.5 , pp. 1183
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 46
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • Cani PD, Possemiers S, Van De Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009; 58: 1091-03
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    Van De Wiele, T.3
  • 47
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49: 1877-87
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 48
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: New evidence in the pathogenesis ofnonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis ofnonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292: G518-25
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G518-G525
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3
  • 49
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinalpermeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg AJ, Roberts-Thomson IC, Dymock RB, et al. The role of small intestinal bacterial overgrowth, intestinalpermeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001; 48: 206-11
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3
  • 50
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 2014; 146(6): 1513-24
    • (2014) Gastroenterology , vol.146 , Issue.6 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 51
    • 33646853899 scopus 로고    scopus 로고
    • Associations between plasma adiponectin concentrations and liver histology in patients withnonalcoholic fatty liver disease
    • Targher G, Bertolini L, Rodella S, et al. Associations between plasma adiponectin concentrations and liver histology in patients withnonalcoholic fatty liver disease. Clin Endocrinol 2006; 64: 679-83
    • (2006) Clin Endocrinol , vol.64 , pp. 679-683
    • Targher, G.1    Bertolini, L.2    Rodella, S.3
  • 52
    • 78649950656 scopus 로고    scopus 로고
    • Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease
    • Bianchi G, Bugianesi E, Frystyk J, et al. Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease. Dig Liver Dis 2011; 43: 73-7
    • (2011) Dig Liver Dis , vol.43 , pp. 73-77
    • Bianchi, G.1    Bugianesi, E.2    Frystyk, J.3
  • 53
    • 3042744737 scopus 로고    scopus 로고
    • Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    • Hui JM, Hodge A, Farrell GC, et al. Beyond insulin resistance in NASH: TNF-alpha or adiponectin?. Hepatology 2004; 40: 46-54
    • (2004) Hepatology , vol.40 , pp. 46-54
    • Hui, J.M.1    Hodge, A.2    Farrell, G.C.3
  • 54
    • 30444461216 scopus 로고    scopus 로고
    • Insulin resistance, adiponectin, cytokines in NASH which is the best target to treat?
    • Larter CZ, Farrell GC. Insulin resistance, adiponectin, cytokines in NASH: which is the best target to treat?. J Hepatol 2006; 44(2): 253-61
    • (2006) J Hepatol , vol.44 , Issue.2 , pp. 253-261
    • Larter, C.Z.1    Farrell, G.C.2
  • 55
    • 79951810722 scopus 로고    scopus 로고
    • Serum total adiponectin in nonalcoholic fatty liver disease: A systematic review and meta-analysis
    • Polyzos SA, Toulis KA, Goulis DG, et al. Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis. Metabolism 2011; 60(3): 313-26
    • (2011) Metabolism , vol.60 , Issue.3 , pp. 313-326
    • Polyzos, S.A.1    Toulis, K.A.2    Goulis, D.G.3
  • 56
    • 84859238635 scopus 로고    scopus 로고
    • Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD
    • Pasarin M, La Mura V, Gracia-Sancho J, et al. Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD. PLoS One 2012; 7(4): e32785
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e32785
    • Pasarin, M.1    La Mura, V.2    Gracia-Sancho, J.3
  • 57
    • 84866865492 scopus 로고    scopus 로고
    • Increased intrahepatic resistance in severe steatosis: Endothelial dysfunction, vasoconstrictor overprodution and altered microvascular architecture
    • Francque S, Lalwman W, Verbeke L, et al. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overprodution and altered microvascular architecture. Lab Invest 2012; 92(10): 1428-39
    • (2012) Lab Invest , vol.92 , Issue.10 , pp. 1428-1439
    • Francque, S.1    Lalwman, W.2    Verbeke, L.3
  • 58
    • 80055043169 scopus 로고    scopus 로고
    • Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
    • Li L, Chen L, Hu L, et al. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 2011; 54(5): 1620-30
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1620-1630
    • Li, L.1    Chen, L.2    Hu, L.3
  • 59
    • 67649669912 scopus 로고    scopus 로고
    • Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease
    • Tajiri K, Shimizu Y, Tsuneyama K, et al. Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur J Gatroenterol Hepatol 2009; 21(6): 673
    • (2009) Eur J Gatroenterol Hepatol , vol.21 , Issue.6 , pp. 673
    • Tajiri, K.1    Shimizu, Y.2    Tsuneyama, K.3
  • 60
    • 84861573996 scopus 로고    scopus 로고
    • Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    • Guy CD, Suzuki A, Zdanowicz M, et al. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology 2012; 55(6): 1711-21
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 1711-1721
    • Guy, C.D.1    Suzuki, A.2    Zdanowicz, M.3
  • 61
    • 78751479915 scopus 로고    scopus 로고
    • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    • Syn WK, Choi SS, Liaskou E, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011; 53(1): 106-15
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 106-115
    • Syn, W.K.1    Choi, S.S.2    Liaskou, E.3
  • 62
    • 4344666158 scopus 로고    scopus 로고
    • Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease
    • Diehl AM. Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8: 619-38
    • (2004) Clin Liver Dis , vol.8 , pp. 619-638
    • Diehl, A.M.1
  • 63
    • 71149086343 scopus 로고    scopus 로고
    • Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    • Rensen SS, Slaats Y, Nijhuis J, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol 2009; 175(4): 1473-82
    • (2009) Am J Pathol , vol.175 , Issue.4 , pp. 1473-1482
    • Rensen, S.S.1    Slaats, Y.2    Nijhuis, J.3
  • 64
    • 73149110853 scopus 로고    scopus 로고
    • Activation of the complement system in human nonalcoholic fatty liver disease
    • Rensen SS, Slaats Y, Driessen A, et al. Activation of the complement system in human nonalcoholic fatty liver disease. Hepatology 2009; 50(6): 1809-17
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1809-1817
    • Rensen, S.S.1    Slaats, Y.2    Driessen, A.3
  • 66
    • 0037335133 scopus 로고    scopus 로고
    • A comparison of fibrosis progression in chronic liver diseases
    • Poynard T, Mathurin P, Lai CL, et al. A comparison of fibrosis progression in chronic liver diseases. J Hepatol 2003; 38: 257
    • (2003) J Hepatol , vol.38 , pp. 257
    • Poynard, T.1    Mathurin, P.2    Lai, C.L.3
  • 67
    • 40049097359 scopus 로고    scopus 로고
    • Liver Cirrhosis
    • Schuppan D, Afdhal NH. Liver Cirrhosis. Lancet 2008; 371(9615): 838-51
    • (2008) Lancet , vol.371 , Issue.9615 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 68
    • 84882906611 scopus 로고    scopus 로고
    • A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
    • Pais R, Charlotte F, Fedchuk L, et al. A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. J Hepatol 2013; 59(3): 550-6
    • (2013) J Hepatol , vol.59 , Issue.3 , pp. 550-556
    • Pais, R.1    Charlotte, F.2    Fedchuk, L.3
  • 69
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of non-alcoholic fatty liver disease: A prospective study with paired liver biopsies at 3 years
    • Wong VW, Wong GL, Choi PC, et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 2010; 59(7): 969-74
    • (2010) Gut , vol.59 , Issue.7 , pp. 969-974
    • Wong, V.W.1    Wong, G.L.2    Choi, P.C.3
  • 70
    • 84864081494 scopus 로고    scopus 로고
    • Features diagnosis and treatment of nonalcoholic fatty liver disease
    • Torres DM, Williams CD, Harrison SA. Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroent and Hepatol 2012; 10(8): 837-58
    • (2012) Clin Gastroent and Hepatol , vol.10 , Issue.8 , pp. 837-858
    • Torres, D.M.1    Williams, C.D.2    Harrison, S.A.3
  • 71
    • 7244250409 scopus 로고    scopus 로고
    • Silent non-alcoholic fatty liver disease-a clinical-histological study
    • Sorrentino P, Tarantino G, Conca P, et al. Silent non-alcoholic fatty liver disease-a clinical-histological study. J Hepatol 2004; 41: 751-7
    • (2004) J Hepatol , vol.41 , pp. 751-757
    • Sorrentino, P.1    Tarantino, G.2    Conca, P.3
  • 72
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-Alcoholic steatohepatitis
    • Argo CK, Northup PG, Al-Osaimi AM, et al. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol 2009; 51(2): 371-9
    • (2009) J Hepatol , vol.51 , Issue.2 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3
  • 73
    • 14644392822 scopus 로고    scopus 로고
    • Histological progression of non-alcoholic fatty liver disease in Chinese patients
    • Hui AY, Wong VW, Chan HL, et al. Histological progression of non-alcoholic fatty liver disease in Chinese patients. Aliment Pharmacol Ther 2005; 21: 407-13
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 407-413
    • Hui, A.Y.1    Wong, V.W.2    Chan, H.L.3
  • 74
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio E, Alvarez E, Domínguez N, et al. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004; 40: 820-6
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Domínguez, N.3
  • 75
    • 84925213635 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: A systematic review and meta-analysis of paired-biopsy studies
    • Epub ahead of print
    • SinghS, Allen AM, Wang Z, et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol 2014. [Epub ahead of print]
    • (2014) Clin Gastroenterol Hepatol
    • Singhs1    Allen, A.M.2    Wang, Z.3
  • 76
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Al-Serri A, Daly AK, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 2010; 51(4): 1209-17
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3
  • 77
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach AC, Batts KB, et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30(6): 1356
    • (1999) Hepatology , vol.30 , Issue.6 , pp. 1356
    • Angulo, P.1    Keach, A.C.2    Batts, K.B.3
  • 78
    • 84887025674 scopus 로고    scopus 로고
    • Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients
    • Noureddin M, Yates KP, Vaughn IA, et al. Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients. Hepatology 2013; 58(5): 1644-54
    • (2013) Hepatology , vol.58 , Issue.5 , pp. 1644-1654
    • Noureddin, M.1    Yates, K.P.2    Vaughn, I.A.3
  • 79
    • 70549105648 scopus 로고    scopus 로고
    • Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease
    • Hossain N Afendy A Stepanova M et al. Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2009 7 11 1224-9
    • (2009) Clin Gastroenterol Hepatol , vol.7 , Issue.11 , pp. 1224-1229
    • Hossain, N.1    Afendy, A.2    Stepanova, M.3
  • 80
    • 83855161551 scopus 로고    scopus 로고
    • Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease
    • Petta S, Amato MC, Di Marco V, et al. Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012; 35(2): 238-47
    • (2012) Aliment Pharmacol Ther , vol.35 , Issue.2 , pp. 238-247
    • Petta, S.1    Amato, M.C.2    Di Marco, V.3
  • 81
    • 0033038672 scopus 로고    scopus 로고
    • Non alcoholic fatty liver disease (a spectrum of clinical and pathological severity
    • Matteoni CA, Younossi ZM, Gramlich T, et al. Non alcoholic fatty liver disease (a spectrum of clinical and pathological severity). Gastroenterology 1999; 116: 1413-19
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 82
    • 0141510580 scopus 로고    scopus 로고
    • The natural history of non alcoholic fatty liver disease (a clinical histopathological study
    • Harrison SA, Torgerson S, Hayashi PH. The natural history of non alcoholic fatty liver disease (a clinical histopathological study). Am J Gastroenterol 2003; 98: 2042-7
    • (2003) Am J Gastroenterol , vol.98 , pp. 2042-2047
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.H.3
  • 83
    • 2342419920 scopus 로고    scopus 로고
    • Long term prognosis of fatty liver (risk of chronic liver disease and death
    • Dam-Larsen S, Franzmann M, Andersen IB, et al. Long term prognosis of fatty liver (risk of chronic liver disease and death). Gut 2004; 53: 750-5
    • (2004) Gut , vol.53 , pp. 750-755
    • Dam-Larsen, S.1    Franzmann, M.2    Andersen, I.B.3
  • 84
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franze-n LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44: 865-73
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franze-N, L.E.2    Mathiesen, U.L.3
  • 85
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28- year follow-up.
    • Söderberg C, Stål P, Askling J, et al. Decreased survival of subjects with elevated liver function tests during a 28- year follow-up. Hepatology 2010; 51: 595-02
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Söderberg, C.1    Stål, P.2    Askling, J.3
  • 86
    • 58849134985 scopus 로고    scopus 로고
    • Longterm follow-up of patients with nonalcoholic fatty liver
    • Rafiq N, Bai C, Fang Y, et al. Longterm follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol 2009; 7: 234-8
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 234-238
    • Rafiq, N.1    Bai, C.2    Fang, Y.3
  • 87
    • 34247647418 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease
    • Hamaguchi M, Kojima T, Takeda N, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007; 13: 1579-84
    • (2007) World J Gastroenterol , vol.13 , pp. 1579-1584
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 88
    • 79960549297 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study
    • Bhala N, Angulo P, Van Der Poorten D, et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 2011; 54: 1208-16
    • (2011) Hepatology , vol.54 , pp. 1208-1216
    • Bhala, N.1    Angulo, P.2    Van Der Poorten, D.3
  • 89
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • Targher G Bertolini L Padovani R et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007 30 1212-18
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3
  • 90
    • 72949097025 scopus 로고    scopus 로고
    • Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl-transpeptidase levels
    • Haring R, Wallaschofski H, Nauck M, et al. Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl-transpeptidase levels. Hepatology 2009; 50: 1403-11
    • (2009) Hepatology , vol.50 , pp. 1403-1411
    • Haring, R.1    Wallaschofski, H.2    Nauck, M.3
  • 91
    • 84868260181 scopus 로고    scopus 로고
    • Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events
    • Vanwagner LB, Bhave M, Te HS, et al. Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events. Hepatology 2012; 56(5): 1741-50
    • (2012) Hepatology , vol.56 , Issue.5 , pp. 1741-1750
    • Vanwagner, L.B.1    Bhave, M.2    Te, H.S.3
  • 92
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-76
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 93
    • 58849090967 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Hashimoto E, Yatsuji S, Tobari M, et al. Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Gastroenterol 2009; 44: 89-95
    • (2009) J Gastroenterol , vol.44 , pp. 89-95
    • Hashimoto, E.1    Yatsuji, S.2    Tobari, M.3
  • 94
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • Paredis V, Zalinski S, Chelbi E, et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 2009; 49(3): 851-9
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 851-859
    • Paredis, V.1    Zalinski, S.2    Chelbi, E.3
  • 95
    • 0033785224 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and hepatocellular carcinoma natural history?
    • Cotrim HP, Parana R, Braga E, et al. Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history?. Am J Gastroenterol 2000; 44: 3018-19
    • (2000) Am J Gastroenterol , vol.44 , pp. 3018-3019
    • Cotrim, H.P.1    Parana, R.2    Braga, E.3
  • 96
    • 0035111170 scopus 로고    scopus 로고
    • Hepatocellular carcinoma arising in non-alcoholic steatohepatitis
    • Zen Y, Katayanagi K, Tsuneyama K, et al. Hepatocellular carcinoma arising in non-alcoholic steatohepatitis. Pathol Int 2001; 51: 127-31
    • (2001) Pathol Int , vol.51 , pp. 127-131
    • Zen, Y.1    Katayanagi, K.2    Tsuneyama, K.3
  • 97
    • 2542424767 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with nonalcoholic steatohepatitis
    • Mori S, Yamasaki T, Sakaida I, et al. Hepatocellular carcinoma with nonalcoholic steatohepatitis. J Gastroenterol 2004; 39: 391-6
    • (2004) J Gastroenterol , vol.39 , pp. 391-396
    • Mori, S.1    Yamasaki, T.2    Sakaida, I.3
  • 98
    • 11344275293 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Cirrhosis, hepatocellular carcinoma and burn-out NASH
    • Yoshioka Y, Hashimoto E, Yatsuji S, et al. Nonalcoholic steatohepatitis: cirrhosis, hepatocellular carcinoma and burn-out NASH. J Gastroenterol 2004; 39: 1215-18
    • (2004) J Gastroenterol , vol.39 , pp. 1215-1218
    • Yoshioka, Y.1    Hashimoto, E.2    Yatsuji, S.3
  • 99
    • 4644261918 scopus 로고    scopus 로고
    • Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma
    • Bullock RE, Zaitoun AM, Aithal GP, et al. Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma. J Hepatol 2004; 41: 685-90
    • (2004) J Hepatol , vol.41 , pp. 685-690
    • Bullock, R.E.1    Zaitoun, A.M.2    Aithal, G.P.3
  • 100
    • 0035991455 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Shimada M, Hashimoto E, Taniai M, et al. Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Hepatol 2002; 37: 154-60
    • (2002) J Hepatol , vol.37 , pp. 154-160
    • Shimada, M.1    Hashimoto, E.2    Taniai, M.3
  • 101
    • 50549084740 scopus 로고    scopus 로고
    • Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease
    • Ong JP, Pitts A, Younossi ZM. Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol 2008; 9: 608-12
    • (2008) J Hepatol , vol.9 , pp. 608-612
    • Ong, J.P.1    Pitts, A.2    Younossi, Z.M.3
  • 102
    • 84902688215 scopus 로고    scopus 로고
    • Risk of development of hepatocellular carcinoma in patients with NASH-related cirrhosis
    • Amarapurkar DN, Dharod M, Gautam S, et al. Risk of development of hepatocellular carcinoma in patients with NASH-related cirrhosis. Trop Gastroenterol 2013; 34(3): 159-63
    • (2013) Trop Gastroenterol , vol.34 , Issue.3 , pp. 159-163
    • Amarapurkar, D.N.1    Dharod, M.2    Gautam, S.3
  • 103
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Ascha MS, Hanouneh IA, Lopez R, et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010; 51(6): 1972-8
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1972-1928
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3
  • 104
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
    • Ratziu VD, Bonyhay L, Di Martino V, et al. Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis. Hepatology 2002; 35: 1485-93
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.D.1    Bonyhay, L.2    Di Martino, V.3
  • 105
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625-38
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3
  • 106
    • 0028302476 scopus 로고
    • Obesity and cancer risk: A Danish record-linkage study
    • Moller H, Mellemgaard A, Lindvig K, et al. Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer 1994; 30A: 344-50
    • (1994) Eur J Cancer , vol.30 A , pp. 344-350
    • Moller, H.1    Mellemgaard, A.2    Lindvig, K.3
  • 107
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence
    • El-Serag HB Hampel H Javadi F. The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidenceClin Gastroenterol Hepatol 2006 4 369-80
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 108
    • 0036894480 scopus 로고    scopus 로고
    • NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
    • Marrero JA, Fontana RJ, Su GL, et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002; 36: 1349-54
    • (2002) Hepatology , vol.36 , pp. 1349-1354
    • Marrero, J.A.1    Fontana, R.J.2    Su, G.L.3
  • 109
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E,Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-40
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 110
    • 1242352395 scopus 로고    scopus 로고
    • Obesity and diabetes as a risk factor for hepatocellular carcinoma
    • Regimbeau JM, Colombat M, Mognol P, et al. Obesity and diabetes as a risk factor for hepatocellular carcinoma. Liver Transpl 2004; 10(2): S69-73
    • (2004) Liver Transpl , vol.10 , Issue.2 , pp. S69-S73
    • Regimbeau, J.M.1    Colombat, M.2    Mognol, P.3
  • 111
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C.
    • Hui JM, Kench JG, Chitturi S, et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 2003; 38(2): 420-7
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3
  • 112
    • 84869436442 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
    • White DL, Kanwal F, El-Sarag H. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gantroenterol Hepatol 2012; 10(12): 1342
    • (2012) Clin Gantroenterol Hepatol , vol.10 , Issue.12 , pp. 1342
    • White, D.L.1    Kanwal, F.2    El-Sarag, H.3
  • 113
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012; 55: 2005-23
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 114
    • 80052012241 scopus 로고    scopus 로고
    • Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis
    • Hernaez R, Lazo M, Bonekamp S, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011; 54: 1082
    • (2011) Hepatology , vol.54 , pp. 1082
    • Hernaez, R.1    Lazo, M.2    Bonekamp, S.3
  • 115
    • 2642521468 scopus 로고    scopus 로고
    • The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients
    • Mottin CC, Moretto M, Padoin AV, et al. The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients. Obes Surg 2004; 14(5): 635-7
    • (2004) Obes Surg , vol.14 , Issue.5 , pp. 635-637
    • Mottin, C.C.1    Moretto, M.2    Padoin, A.V.3
  • 116
    • 39549102206 scopus 로고    scopus 로고
    • Preoperative radiographic assessment of hepatic steatosis with histologic correlation
    • Cho CS, Curran S, Schwartz LH, et al. Preoperative radiographic assessment of hepatic steatosis with histologic correlation. J Am Coll Surg 2008; 206(3): 480
    • (2008) J Am Coll Surg , vol.206 , Issue.3 , pp. 480
    • Cho, C.S.1    Curran, S.2    Schwartz, L.H.3
  • 117
    • 84891889855 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: Non-invasive assessment of non-alcoholic fatty liver disease - The role of transient elastography and plasma cytokeratin-18 fragments
    • Kwok R, Tse YK, Wong GL, et al. Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease - the role of transient elastography and plasma cytokeratin-18 fragments. Aliment Pharmacol Ther 2014; 39(3): 254-69
    • (2014) Aliment Pharmacol Ther , vol.39 , Issue.3 , pp. 254-269
    • Kwok, R.1    Tse, Y.K.2    Wong, G.L.3
  • 118
    • 84900556498 scopus 로고    scopus 로고
    • Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: A meta-analysis of diagnostic accuracy
    • Shi KQ, Tang JZ, Zhu XL, et al. Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: a meta-analysis of diagnostic accuracy. J Gastroenterol Hepatol 2014; 29(6): 1149-58
    • (2014) J Gastroenterol Hepatol , vol.29 , Issue.6 , pp. 1149-1158
    • Shi, K.Q.1    Tang, J.Z.2    Zhu, X.L.3
  • 119
    • 84876907610 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis
    • Tang A, Tan J, Sun M, et al. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology 2013; 267(2): 422-31
    • (2013) Radiology , vol.267 , Issue.2 , pp. 422-431
    • Tang, A.1    Tan, J.2    Sun, M.3
  • 120
    • 84878274416 scopus 로고    scopus 로고
    • Hepatic steatosis: Quantification by proton density fat fraction with MR imaging versus liver biopsy
    • Idilman IS, Aniktar H, Idilman R, et al. Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy. Radiology 2013; 267(3): 767-75
    • (2013) Radiology , vol.267 , Issue.3 , pp. 767-775
    • Idilman, I.S.1    Aniktar, H.2    Idilman, R.3
  • 121
    • 68049120181 scopus 로고    scopus 로고
    • Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    • Schwenzer NF, Springer F, Schraml C, et al. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009; 51: 433
    • (2009) J Hepatol , vol.51 , pp. 433
    • Schwenzer, N.F.1    Springer, F.2    Schraml, C.3
  • 122
    • 77956639983 scopus 로고    scopus 로고
    • Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
    • Neuschwander-Tetri BA, Clark JM, Bass NM, et al. Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology 2010; 52: 913
    • (2010) Hepatology , vol.52 , pp. 913
    • Neuschwander-Tetri, B.A.1    Clark, J.M.2    Bass, N.M.3
  • 123
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso G, Gambino R, Cassader M, et al. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 2011; 43(8): 617-49
    • (2011) Ann Med , vol.43 , Issue.8 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 124
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313
    • (2005) Hepatology , vol.41 , pp. 1313
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 125
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010; 51: 121
    • (2010) Hepatology , vol.51 , pp. 121
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 126
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • Andersen T, Gluud C, Franzmann MB, et al. Hepatic effects of dietary weight loss in morbidly obese subjects. J Hepatol 1991; 12: 224
    • (1991) J Hepatol , vol.12 , pp. 224
    • Andersen, T.1    Gluud, C.2    Franzmann, M.B.3
  • 127
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin e treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr 2000; 136: 734
    • (2000) J Pediatr , vol.136 , pp. 734
    • Lavine, J.E.1
  • 128
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362: 1675-85
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 129
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355: 2297
    • (2006) N Engl J Med , vol.355 , pp. 2297
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 130
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal GP, Thomas JA, Kaye PV, et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008; 135: 1176
    • (2008) Gastroenterology , vol.135 , pp. 1176
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 131
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V, Giral P, Jacqueminet S, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008; 135: 100
    • (2008) Gastroenterology , vol.135 , pp. 100
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 132
    • 83555164835 scopus 로고    scopus 로고
    • Meta-analysis: Pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
    • Boettcher E, Csako G, Pucino F, et al. Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2012; 35: 66
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 66
    • Boettcher, E.1    Csako, G.2    Pucino, F.3
  • 133
    • 84866358522 scopus 로고    scopus 로고
    • Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study
    • Neumann A, Weill A, Ricordeau P, et al. Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study. Diabetologia 2012; 55: 1953
    • (2012) Diabetologia , vol.55 , pp. 1953
    • Neumann, A.1    Weill, A.2    Ricordeau, P.3
  • 134
    • 78249262957 scopus 로고    scopus 로고
    • Meta-analysis: Insulin sensitizers for the treatment of non-alcoholic steatohepatitis
    • Rakoski MO, Singal AG, Rogers MA, et al. Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2010; 32: 1211
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1211
    • Rakoski, M.O.1    Singal, A.G.2    Rogers, M.A.3
  • 135
    • 84908632327 scopus 로고    scopus 로고
    • SIRT1 Mediates the Effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
    • Xu F, Li Z, Zheng X, et al. SIRT1 Mediates the Effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes 2014; 63(11): 3637-46
    • (2014) Diabetes , vol.63 , Issue.11 , pp. 3637-3646
    • Xu, F.1    Li, Z.2    Zheng, X.3
  • 136
    • 14844310240 scopus 로고    scopus 로고
    • Immunomodulating and anti-apoptotic action of ursodeoxycholic acid where are we and where should we go?
    • Bellentani S. Immunomodulating and anti-apoptotic action of ursodeoxycholic acid: where are we and where should we go?. Eur J Gastroenterol Hepatol 2005; 17: 137
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 137
    • Bellentani, S.1
  • 137
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • Lindor KD, Kowdley KV, Heathcote EJ, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004; 39: 770
    • (2004) Hepatology , vol.39 , pp. 770
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 138
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial
    • Leuschner UF, Lindenthal B, Herrmann G, et al. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology 2010; 52(2): 472-9
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Herrmann, G.3
  • 139
    • 84858622244 scopus 로고    scopus 로고
    • Ursodeoxycholic acid with vitamin e in patients with nonalcoholic steatohepatitis:long-term results
    • Pietu F, Guillaud O, Walter T, et al. Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis:long-term results. Clin Res Hepatol Gastroenterol 2012; 36: 146
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 146
    • Pietu, F.1    Guillaud, O.2    Walter, T.3
  • 140
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of Orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi S, Kessler A, Brazowsky E, et al. A double-blind randomized placebo-controlled trial of Orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2006; 4(5): 639
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.5 , pp. 639
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3
  • 141
    • 0037383865 scopus 로고    scopus 로고
    • Probucol in the treatment of non-alcoholic steatohepatitis: A double-blind randomized controlled study
    • Merat S, Malekzadeh R, Sohrabi MR, et al. Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study. J Hepatol 2003; 38(4): 414
    • (2003) J Hepatol , vol.38 , Issue.4 , pp. 414
    • Merat, S.1    Malekzadeh, R.2    Sohrabi, M.R.3
  • 142
    • 73149092115 scopus 로고    scopus 로고
    • Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial
    • Abdelmalek MF, Sanderson SO, Angulo P, et al. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology 2009; 50(6): 1818
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1818
    • Abdelmalek, M.F.1    Sanderson, S.O.2    Angulo, P.3
  • 143
    • 78650971903 scopus 로고    scopus 로고
    • Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: The St Francis Heart Study randomized clinical trial
    • Foster T, Budoff MJ, Saab S, et al. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am J Gastroenterol 2011; 106(1): 71
    • (2011) Am J Gastroenterol , vol.106 , Issue.1 , pp. 71
    • Foster, T.1    Budoff, M.J.2    Saab, S.3
  • 144
    • 79959446947 scopus 로고    scopus 로고
    • Pentoxifylline for the treatment of non-alcoholic steatohepatitis: A randomized controlled trial
    • Van Wagner LB, Koppe SW, Brunt EM, et al. Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial. Ann Hepatol 2011; 10(3): 277-86
    • (2011) Ann Hepatol , vol.10 , Issue.3 , pp. 277-286
    • Van Wagner, L.B.1    Koppe, S.W.2    Brunt, E.M.3
  • 145
    • 84918791665 scopus 로고    scopus 로고
    • Resveratrol does not benefit patientswith non-alcoholic fatty liver disease
    • Chachay VS, Macdonald GA. Martin, JH, et al. Resveratrol does not benefit patientswith non-alcoholic fatty liver disease. Clin Gastroenterol Hepatol 2014; 12(12): 2092-103
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.12 , pp. 2092-2103
    • Chachay, V.S.1    MacDonald, G.A.2    Martin, J.H.3
  • 146
    • 84904661185 scopus 로고    scopus 로고
    • No significant Effects of Ethyl-Eicosapentoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial
    • Sanyal A, Abdelmalek M, Suzuki A, et al. No significant Effects of Ethyl-Eicosapentoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial. Gastroenterology 2014; 147(2): 377-84
    • (2014) Gastroenterology , vol.147 , Issue.2 , pp. 377-384
    • Sanyal, A.1    Abdelmalek, M.2    Suzuki, A.3
  • 147
    • 84896770640 scopus 로고    scopus 로고
    • Design and rationale of the WELCOME trial: A randomised placebo controlled study to test the efficacy of purified long chain omega-3 fatty treatment in non-alcoholic fatty liver disease
    • Scorletti E, Bhatia L, McCormick KG, et al. Design and rationale of the WELCOME trial: a randomised, placebo controlled study to test the efficacy of purified long chain omega-3 fatty treatment in non-alcoholic fatty liver disease. Contemp Clin Trials 2014; 37(2): 301-11
    • (2014) Contemp Clin Trials , vol.37 , Issue.2 , pp. 301-311
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3
  • 148
    • 33646363759 scopus 로고    scopus 로고
    • NAFLD, obesity, and bariatric surgery
    • Angulo P. NAFLD, obesity, and bariatric surgery. Gastroenterology 2006; 130: 1848-52
    • (2006) Gastroenterology , vol.130 , pp. 1848-1852
    • Angulo, P.1
  • 149
    • 33947247615 scopus 로고    scopus 로고
    • Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years
    • Furuya CK Jr, De Oliveira CP, De Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol 2007; 224): 510
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.4 , pp. 510
    • Furuya, C.K.1    De Oliveira, C.P.2    De Mello, E.S.3
  • 150
    • 67650951419 scopus 로고    scopus 로고
    • Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease
    • Mathurin P, Hollebecque A, Arnalsteen L, et al. Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 2009; 137(2): 532-40
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 532-540
    • Mathurin, P.1    Hollebecque, A.2    Arnalsteen, L.3
  • 153
    • 84907326817 scopus 로고    scopus 로고
    • Screening for hepatocellular carcinoma in chronic liver disease: A systematic review
    • Kansagara D, Papak J, Pasha AS, et al. Screening for hepatocellular carcinoma in chronic liver disease: a systematic review. Ann Intern Med 2014; 161(4): 261-9
    • (2014) Ann Intern Med , vol.161 , Issue.4 , pp. 261-269
    • Kansagara, D.1    Papak, J.2    Pasha, A.S.3
  • 154
    • 3843125293 scopus 로고    scopus 로고
    • Randomized controlled trial of screening for hepatocellular carcinoma
    • Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 2004; 130: 417-22
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 417-422
    • Zhang, B.H.1    Yang, B.H.2    Tang, Z.Y.3
  • 155
    • 0346495966 scopus 로고    scopus 로고
    • Screening for liver cancer: Results of a randomised controlled trial in Qidong. China
    • Chen JG, Parkin DM, Chen QG, et al. Screening for liver cancer: results of a randomised controlled trial in Qidong. China. J Med Screen 2003; 10: 204-9
    • (2003) J Med Screen , vol.10 , pp. 204-209
    • Chen, J.G.1    Parkin, D.M.2    Chen, Q.G.3
  • 156
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. AASLD Practise Guideline 2011(3): 1020-2
    • (2011) AASLD Practise Guideline , vol.3 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 157
    • 80052245888 scopus 로고    scopus 로고
    • Health and economic burden of the projected obesity trends in the USA and the UK
    • Wang YC, McPherson K, Marsh T, et al. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378(9793): 815-25
    • (2011) Lancet , vol.378 , Issue.9793 , pp. 815-825
    • Wang, Y.C.1    McPherson, K.2    Marsh, T.3
  • 158
    • 84891400789 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Hawkey CJ Bosch J Richter JE et al. editors John Wiley and Sons, Ltd; Chichester, West Sussex
    • McCullough AJ, Dasarathy S. Nonalcoholic Fatty Liver Disease. In Hawkey CJ, Bosch J, Richter JE, et al. editors. Textbook of Clinical Gastroenterology and Hepatology. John Wiley and Sons, Ltd; Chichester, West Sussex: 2012
    • (2012) Textbook of Clinical Gastroenterology and Hepatology
    • McCullough, A.J.1    Dasarathy, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.