-
3
-
-
84876940723
-
Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs
-
Iwamoto T. Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs. Biol Pharm Bull 2013, 36:715-718.
-
(2013)
Biol Pharm Bull
, vol.36
, pp. 715-718
-
-
Iwamoto, T.1
-
4
-
-
0028962573
-
Scope and limitations of gene therapy
-
Weatherall D.J. Scope and limitations of gene therapy. Br Med Bull 1995, 51:1-11.
-
(1995)
Br Med Bull
, vol.51
, pp. 1-11
-
-
Weatherall, D.J.1
-
5
-
-
84886075928
-
Gene therapy: promises, problems and prospects
-
Somia N., Wang L., Gage F. Gene therapy: promises, problems and prospects. Genes Resist Dis 2000, 147.
-
(2000)
Genes Resist Dis
, vol.147
-
-
Somia, N.1
Wang, L.2
Gage, F.3
-
6
-
-
0034159940
-
Gene therapy: the first decade
-
Mountain A. Gene therapy: the first decade. Trends Biotechnol 2000, 18:119-128.
-
(2000)
Trends Biotechnol
, vol.18
, pp. 119-128
-
-
Mountain, A.1
-
7
-
-
84928534606
-
Stem Cell Network
-
[accessed 12].
-
Stem Cell Network, Cancer: solid tumor, [accessed 12/2014]. http://www.stemcellnetwork.ca/index.php?page=cancers-solid-tumor.
-
(2014)
Cancer: solid tumor
-
-
-
8
-
-
39749172398
-
Tumor hypoxia in cancer therapy
-
Brown J.M. Tumor hypoxia in cancer therapy. Methods Enzym 2007, 435:297-321.
-
(2007)
Methods Enzym
, vol.435
, pp. 297-321
-
-
Brown, J.M.1
-
9
-
-
0035925098
-
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
-
Hockel M., Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001, 93:266-276.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
10
-
-
1542408478
-
Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours
-
Weinmann M., Belka C., Plasswilm L. Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours. Onkologie 2004, 27:83-90.
-
(2004)
Onkologie
, vol.27
, pp. 83-90
-
-
Weinmann, M.1
Belka, C.2
Plasswilm, L.3
-
11
-
-
34547121206
-
Hypoxia in cancer: significance and impact on clinical outcome
-
Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer metastasis Rev 2007, 26:225-239.
-
(2007)
Cancer metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
12
-
-
26444466467
-
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
-
Nordsmark M., Bentzen S.M., Rudat V., Brizel D., Lartigau E., Stadler P., et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol: J Eur Soc Ther Radiol Oncol 2005, 77:18-24.
-
(2005)
Radiother Oncol: J Eur Soc Ther Radiol Oncol
, vol.77
, pp. 18-24
-
-
Nordsmark, M.1
Bentzen, S.M.2
Rudat, V.3
Brizel, D.4
Lartigau, E.5
Stadler, P.6
-
13
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
-
Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996, 56:941-943.
-
(1996)
Cancer Res
, vol.56
, pp. 941-943
-
-
Brizel, D.M.1
Scully, S.P.2
Harrelson, J.M.3
Layfield, L.J.4
Bean, J.M.5
Prosnitz, L.R.6
-
14
-
-
0027339592
-
Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
-
Hockel M., Knoop C., Schlenger K., Vorndran B., Baussmann E., Mitze M., et al. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol: J Eur Soc Ther Radiol Oncol 1993, 26:45-50.
-
(1993)
Radiother Oncol: J Eur Soc Ther Radiol Oncol
, vol.26
, pp. 45-50
-
-
Hockel, M.1
Knoop, C.2
Schlenger, K.3
Vorndran, B.4
Baussmann, E.5
Mitze, M.6
-
15
-
-
82255167669
-
Targeting hypoxic tumour cells to overcome metastasis
-
Bennewith K.L., Dedhar S. Targeting hypoxic tumour cells to overcome metastasis. BMC cancer 2011, 11:504.
-
(2011)
BMC cancer
, vol.11
, pp. 504
-
-
Bennewith, K.L.1
Dedhar, S.2
-
16
-
-
33746851956
-
Tumor metastasis: mechanistic insights and clinical challenges
-
Steeg P.S. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006, 12:895-904.
-
(2006)
Nat Med
, vol.12
, pp. 895-904
-
-
Steeg, P.S.1
-
17
-
-
2942615346
-
Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
-
Duffy J.P., Eibl G., Reber H.A., Hines O.J. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol cancer 2003, 2:12.
-
(2003)
Mol cancer
, vol.2
, pp. 12
-
-
Duffy, J.P.1
Eibl, G.2
Reber, H.A.3
Hines, O.J.4
-
18
-
-
80855133898
-
Clostridia: sporeforming anaerobic Bacilli
-
Galveston (TX), S. Baron (Ed.)
-
Wells C.L., Wilkins T.D. Clostridia: sporeforming anaerobic Bacilli. Medical microbiology 1996, Galveston (TX). S. Baron (Ed.).
-
(1996)
Medical microbiology
-
-
Wells, C.L.1
Wilkins, T.D.2
-
19
-
-
33645450217
-
Tumor lysis of a glioblastoma by Clostridium oncolyticum
-
Marth E., Ascher W.P., Pavelka R., Mose J.R. Tumor lysis of a glioblastoma by Clostridium oncolyticum. J Chemother 1989, 1:1177-1178.
-
(1989)
J Chemother
, vol.1
, pp. 1177-1178
-
-
Marth, E.1
Ascher, W.P.2
Pavelka, R.3
Mose, J.R.4
-
20
-
-
0032144380
-
Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours
-
Lambin P., Theys J., Landuyt W., Rijken P., van der Kogel A., van der Schueren E., et al. Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours. Anaerobe 1998, 4:183-188.
-
(1998)
Anaerobe
, vol.4
, pp. 183-188
-
-
Lambin, P.1
Theys, J.2
Landuyt, W.3
Rijken, P.4
van der Kogel, A.5
van der Schueren, E.6
-
21
-
-
0035552380
-
Clostridium as a tumor-specific delivery system of therapeutic proteins
-
Theys J., Landuyt A.W., Nuyts S., Van Mellaert L., Lambin P., Anne J. Clostridium as a tumor-specific delivery system of therapeutic proteins. Cancer Detect Prev 2001, 25:548-557.
-
(2001)
Cancer Detect Prev
, vol.25
, pp. 548-557
-
-
Theys, J.1
Landuyt, A.W.2
Nuyts, S.3
Van Mellaert, L.4
Lambin, P.5
Anne, J.6
-
23
-
-
34347246680
-
Potential and limitations of bacterial-mediated cancer therapy
-
Mengesha A., Dubois L., Chiu R.K., Paesmans K., Wouters B.G., Lambin P., et al. Potential and limitations of bacterial-mediated cancer therapy. Front Biosci: J Virtual Libr 2007, 12:3880-3891.
-
(2007)
Front Biosci: J Virtual Libr
, vol.12
, pp. 3880-3891
-
-
Mengesha, A.1
Dubois, L.2
Chiu, R.K.3
Paesmans, K.4
Wouters, B.G.5
Lambin, P.6
-
24
-
-
53049087992
-
Bacterial therapies: completing the cancer treatment toolbox
-
St Jean A.T., Zhang M., Forbes N.S. Bacterial therapies: completing the cancer treatment toolbox. Curr Opin Biotechnol 2008, 19:511-517.
-
(2008)
Curr Opin Biotechnol
, vol.19
, pp. 511-517
-
-
St Jean, A.T.1
Zhang, M.2
Forbes, N.S.3
-
25
-
-
37049011374
-
Bacterial targeted tumour therapy-dawn of a new era
-
Wei M.Q., Mengesha A., Good D., Anne J. Bacterial targeted tumour therapy-dawn of a new era. Cancer Lett 2008, 259:16-27.
-
(2008)
Cancer Lett
, vol.259
, pp. 16-27
-
-
Wei, M.Q.1
Mengesha, A.2
Good, D.3
Anne, J.4
-
26
-
-
84891099250
-
Tumor-colonizing bacteria: a potential tumor targeting therapy
-
Zu C., Wang J. Tumor-colonizing bacteria: a potential tumor targeting therapy. Crit Rev Microbiol 2014, 40:225-235.
-
(2014)
Crit Rev Microbiol
, vol.40
, pp. 225-235
-
-
Zu, C.1
Wang, J.2
-
27
-
-
0000775441
-
Oncolysis by clostridia. I. Activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma
-
Moese J.R., Moese G. Oncolysis by clostridia. I. Activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma. Cancer Res 1964, 24:212-216.
-
(1964)
Cancer Res
, vol.24
, pp. 212-216
-
-
Moese, J.R.1
Moese, G.2
-
28
-
-
78651160643
-
Oncolysis by clostridia. Iv. Effect of nonpathogenic clostridial spores in normal and pathological tissues
-
Thiele E.H., Arison R.N., Boxer G.E. Oncolysis by clostridia. Iv. Effect of nonpathogenic clostridial spores in normal and pathological tissues. Cancer Res 1964, 24:234-238.
-
(1964)
Cancer Res
, vol.24
, pp. 234-238
-
-
Thiele, E.H.1
Arison, R.N.2
Boxer, G.E.3
-
29
-
-
78651152166
-
Oncolysis by clostridia. Iii. Effects of clostridia and chemotherapeutic agents on rodent tumors
-
Thiele E.H., Arison R.N., Boxer G.E. Oncolysis by clostridia. Iii. Effects of clostridia and chemotherapeutic agents on rodent tumors. Cancer Res 1964, 24:222-233.
-
(1964)
Cancer Res
, vol.24
, pp. 222-233
-
-
Thiele, E.H.1
Arison, R.N.2
Boxer, G.E.3
-
30
-
-
0030865697
-
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment
-
Lemmon M.J., van Zijl P., Fox M.E., Mauchline M.L., Giaccia A.J., Minton N.P., et al. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther 1997, 4:791-796.
-
(1997)
Gene Ther
, vol.4
, pp. 791-796
-
-
Lemmon, M.J.1
van Zijl, P.2
Fox, M.E.3
Mauchline, M.L.4
Giaccia, A.J.5
Minton, N.P.6
-
31
-
-
40149088986
-
Prodrugs: design and clinical applications
-
Rautio J., Kumpulainen H., Heimbach T., Oliyai R., Oh D., Järvinen T., et al. Prodrugs: design and clinical applications. Nat Rev Drug Discov 2008, 7:255-270.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 255-270
-
-
Rautio, J.1
Kumpulainen, H.2
Heimbach, T.3
Oliyai, R.4
Oh, D.5
Järvinen, T.6
-
32
-
-
34548026715
-
-
Springer
-
Stella V., Borchardt R., Hageman M., Oliyai R., Maag H., Tilley J. Prodrugs: challenges and rewards 2007, Springer.
-
(2007)
Prodrugs: challenges and rewards
-
-
Stella, V.1
Borchardt, R.2
Hageman, M.3
Oliyai, R.4
Maag, H.5
Tilley, J.6
-
33
-
-
0014525030
-
2, 4-Dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256
-
Cobb L., Connors T., Elson L., Khan A., Mitchley B., Ross W., et al. 2, 4-Dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256. Biochem Pharmacol 1969, 18:1519-1527.
-
(1969)
Biochem Pharmacol
, vol.18
, pp. 1519-1527
-
-
Cobb, L.1
Connors, T.2
Elson, L.3
Khan, A.4
Mitchley, B.5
Ross, W.6
-
34
-
-
0027234856
-
Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954
-
Knox R.J., Friedlos F., Biggs P.J., Flitter W.D., Gaskell M., Goddard P., et al. Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954. Biochem Pharmacol 1993, 46:797-803.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 797-803
-
-
Knox, R.J.1
Friedlos, F.2
Biggs, P.J.3
Flitter, W.D.4
Gaskell, M.5
Goddard, P.6
-
35
-
-
0026677838
-
The bioactivation of 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954)-II: a comparison of an Escherichia coli nitroreductase and Walker DT diaphorase
-
Knox R.J., Friedlos F., Sherwood R.F., Melton R.G., Anlezark G.M. The bioactivation of 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954)-II: a comparison of an Escherichia coli nitroreductase and Walker DT diaphorase. Biochem Pharmacol 1992, 44:2297-2301.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 2297-2301
-
-
Knox, R.J.1
Friedlos, F.2
Sherwood, R.F.3
Melton, R.G.4
Anlezark, G.M.5
-
36
-
-
0036150373
-
Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954
-
Anlezark G.M., Vaughan T., Fashola-Stone E., Michael N.P., Murdoch H., Sims M.A., et al. Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology 2002, 148:297-306.
-
(2002)
Microbiology
, vol.148
, pp. 297-306
-
-
Anlezark, G.M.1
Vaughan, T.2
Fashola-Stone, E.3
Michael, N.P.4
Murdoch, H.5
Sims, M.A.6
-
37
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown J.M., Wilson W.R. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004, 4:437-447.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
38
-
-
33750480202
-
Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects invivo
-
Theys J., Pennington O., Dubois L., Anlezark G., Vaughan T., Mengesha A., et al. Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects invivo. Br J cancer 2006, 95:1212-1219.
-
(2006)
Br J cancer
, vol.95
, pp. 1212-1219
-
-
Theys, J.1
Pennington, O.2
Dubois, L.3
Anlezark, G.4
Vaughan, T.5
Mengesha, A.6
-
39
-
-
1842613536
-
Clostridia in cancer therapy
-
Minton N.P. Clostridia in cancer therapy. Nat Rev Microbiol 2003, 1:237-242.
-
(2003)
Nat Rev Microbiol
, vol.1
, pp. 237-242
-
-
Minton, N.P.1
-
40
-
-
0028844617
-
Chemotherapeutic tumour targeting using clostridial spores
-
Minton N.P., Mauchline M.L., Lemmon M.J., Brehm J.K., Fox M., Michael N.P., et al. Chemotherapeutic tumour targeting using clostridial spores. FEMS Microbiol Rev 2006, 17:357-364.
-
(2006)
FEMS Microbiol Rev
, vol.17
, pp. 357-364
-
-
Minton, N.P.1
Mauchline, M.L.2
Lemmon, M.J.3
Brehm, J.K.4
Fox, M.5
Michael, N.P.6
-
42
-
-
0022657307
-
CB 1954 revisited. II. Toxicity and antitumour activity
-
Workman P., Morgan J.E., Talbot K., Wright K.A., Donaldson J., Twentyman P.R. CB 1954 revisited. II. Toxicity and antitumour activity. Cancer Chemother Pharmacol 1986, 16:9-14.
-
(1986)
Cancer Chemother Pharmacol
, vol.16
, pp. 9-14
-
-
Workman, P.1
Morgan, J.E.2
Talbot, K.3
Wright, K.A.4
Donaldson, J.5
Twentyman, P.R.6
-
43
-
-
0024209370
-
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells
-
Knox R.J., Friedlos F., Jarman M., Roberts J.J. A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells. Biochem Pharmacol 1988, 37:4661-4669.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 4661-4669
-
-
Knox, R.J.1
Friedlos, F.2
Jarman, M.3
Roberts, J.J.4
-
44
-
-
0034814342
-
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954
-
Chung-Faye G., Palmer D., Anderson D., Clark J., Downes M., Baddeley J., et al. Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954. Clin cancer Res: Off J Am Assoc Cancer Res 2001, 7:2662-2668.
-
(2001)
Clin cancer Res: Off J Am Assoc Cancer Res
, vol.7
, pp. 2662-2668
-
-
Chung-Faye, G.1
Palmer, D.2
Anderson, D.3
Clark, J.4
Downes, M.5
Baddeley, J.6
-
45
-
-
28244460232
-
Aerobic 2- and 4-nitroreduction of CB 1954 by human liver
-
Tang M.H., Helsby N.A., Wilson W.R., Tingle M.D. Aerobic 2- and 4-nitroreduction of CB 1954 by human liver. Toxicology 2005, 216:129-139.
-
(2005)
Toxicology
, vol.216
, pp. 129-139
-
-
Tang, M.H.1
Helsby, N.A.2
Wilson, W.R.3
Tingle, M.D.4
-
46
-
-
54249167548
-
Optimized Clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104
-
Liu S.C., Ahn G.O., Kioi M., Dorie M.J., Patterson A.V., Brown J.M. Optimized Clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104. Cancer Res 2008, 68:7995-8003.
-
(2008)
Cancer Res
, vol.68
, pp. 7995-8003
-
-
Liu, S.C.1
Ahn, G.O.2
Kioi, M.3
Dorie, M.J.4
Patterson, A.V.5
Brown, J.M.6
-
47
-
-
34447122556
-
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
-
Patterson A.V., Ferry D.M., Edmunds S.J., Gu Y., Singleton R.S., Patel K., et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin cancer Res: Off J Am Assoc Cancer Res 2007, 13:3922-3932.
-
(2007)
Clin cancer Res: Off J Am Assoc Cancer Res
, vol.13
, pp. 3922-3932
-
-
Patterson, A.V.1
Ferry, D.M.2
Edmunds, S.J.3
Gu, Y.4
Singleton, R.S.5
Patel, K.6
-
48
-
-
76749161362
-
The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3
-
Guise C.P., Abbattista M.R., Singleton R.S., Holford S.D., Connolly J., Dachs G.U., et al. The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Res 2010, 70:1573-1584.
-
(2010)
Cancer Res
, vol.70
, pp. 1573-1584
-
-
Guise, C.P.1
Abbattista, M.R.2
Singleton, R.S.3
Holford, S.D.4
Connolly, J.5
Dachs, G.U.6
-
49
-
-
84867748471
-
PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours
-
McKeage M.J., Jameson M.B., Ramanathan R.K., Rajendran J., Gu Y., Wilson W.R., et al. PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours. BMC cancer 2012, 12:496.
-
(2012)
BMC cancer
, vol.12
, pp. 496
-
-
McKeage, M.J.1
Jameson, M.B.2
Ramanathan, R.K.3
Rajendran, J.4
Gu, Y.5
Wilson, W.R.6
-
50
-
-
36148966477
-
The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR)
-
Singleton D.C., Li D., Bai S.Y., Syddall S.P., Smaill J.B., Shen Y., et al. The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR). Cancer gene Ther 2007, 14:953-967.
-
(2007)
Cancer gene Ther
, vol.14
, pp. 953-967
-
-
Singleton, D.C.1
Li, D.2
Bai, S.Y.3
Syddall, S.P.4
Smaill, J.B.5
Shen, Y.6
-
51
-
-
0141592778
-
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954
-
Grove J.I., Lovering A.L., Guise C., Race P.R., Wrighton C.J., White S.A., et al. Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954. Cancer Res 2003, 63:5532-5537.
-
(2003)
Cancer Res
, vol.63
, pp. 5532-5537
-
-
Grove, J.I.1
Lovering, A.L.2
Guise, C.3
Race, P.R.4
Wrighton, C.J.5
White, S.A.6
-
52
-
-
34047136503
-
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954
-
Race P.R., Lovering A.L., White S.A., Grove J.I., Searle P.F., Wrighton C.W., et al. Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954. J Mol Biol 2007, 368:481-492.
-
(2007)
J Mol Biol
, vol.368
, pp. 481-492
-
-
Race, P.R.1
Lovering, A.L.2
White, S.A.3
Grove, J.I.4
Searle, P.F.5
Wrighton, C.W.6
-
54
-
-
56949084154
-
Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation
-
Emptage C.D., Knox R.J., Danson M.J., Hough D.W. Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation. Biochem Pharmacol 2009, 77:21-29.
-
(2009)
Biochem Pharmacol
, vol.77
, pp. 21-29
-
-
Emptage, C.D.1
Knox, R.J.2
Danson, M.J.3
Hough, D.W.4
-
55
-
-
0035023209
-
Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum
-
Theys J., Landuyt W., Nuyts S., Van Mellaert L., van Oosterom A., Lambin P., et al. Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther 2001, 8:294-297.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 294-297
-
-
Theys, J.1
Landuyt, W.2
Nuyts, S.3
Van Mellaert, L.4
van Oosterom, A.5
Lambin, P.6
-
56
-
-
84860362257
-
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker
-
Heap J.T., Ehsaan M., Cooksley C.M., Ng Y.K., Cartman S.T., Winzer K., et al. Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker. Nucleic Acids Res 2012, 40:e59.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. e59
-
-
Heap, J.T.1
Ehsaan, M.2
Cooksley, C.M.3
Ng, Y.K.4
Cartman, S.T.5
Winzer, K.6
-
57
-
-
84898941744
-
Spores of Clostridium engineered for clinical efficacy and safety causeregression and cure of tumors invivo
-
Heap J.T., Theys J., Ehsaan M., Kubiak A.M., Dubois L., Paesmans K., et al. Spores of Clostridium engineered for clinical efficacy and safety causeregression and cure of tumors invivo. Oncotarget 2014, 5(7):1761-1769.
-
(2014)
Oncotarget
, vol.5
, Issue.7
, pp. 1761-1769
-
-
Heap, J.T.1
Theys, J.2
Ehsaan, M.3
Kubiak, A.M.4
Dubois, L.5
Paesmans, K.6
-
58
-
-
0035909908
-
Combination bacteriolytic therapy for the treatment of experimental tumors
-
Dang L.H., Bettegowda C., Huso D.L., Kinzler K.W., Vogelstein B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci U S A 2001, 98:15155-15160.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 15155-15160
-
-
Dang, L.H.1
Bettegowda, C.2
Huso, D.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
59
-
-
6344253429
-
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents
-
Dang L.H., Bettegowda C., Agrawal N., Cheong I., Huso D., Frost P., et al. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biol Ther 2004, 3:326-337.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 326-337
-
-
Dang, L.H.1
Bettegowda, C.2
Agrawal, N.3
Cheong, I.4
Huso, D.5
Frost, P.6
-
60
-
-
21744455884
-
Discodermolide analogues as the chemical component of combination bacteriolytic therapy
-
Smith A.B., Freeze B.S., LaMarche M.J., Sager J., Kinzler K.W., Vogelstein B. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorg Med Chem Lett 2005, 15:3623-3626.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 3623-3626
-
-
Smith, A.B.1
Freeze, B.S.2
LaMarche, M.J.3
Sager, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
61
-
-
10744232132
-
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
-
Bettegowda C., Dang L.H., Abrams R., Huso D.L., Dillehay L., Cheong I., et al. Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria. Proc Natl Acad Sci U S A 2003, 100:15083-15088.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15083-15088
-
-
Bettegowda, C.1
Dang, L.H.2
Abrams, R.3
Huso, D.L.4
Dillehay, L.5
Cheong, I.6
-
62
-
-
33751586094
-
A bacterial protein enhances the release and efficacy of liposomal cancer drugs
-
Cheong I., Huang X., Bettegowda C., Diaz L.A., Kinzler K.W., Zhou S., et al. A bacterial protein enhances the release and efficacy of liposomal cancer drugs. Science 2006, 314:1308-1311.
-
(2006)
Science
, vol.314
, pp. 1308-1311
-
-
Cheong, I.1
Huang, X.2
Bettegowda, C.3
Diaz, L.A.4
Kinzler, K.W.5
Zhou, S.6
-
63
-
-
36049044554
-
Functional antibodies produced by oncolytic clostridia
-
Groot A.J., Mengesha A., van der Wall E., van Diest P.J., Theys J., Vooijs M. Functional antibodies produced by oncolytic clostridia. Biochem Biophys Res Commun 2007, 364:985-989.
-
(2007)
Biochem Biophys Res Commun
, vol.364
, pp. 985-989
-
-
Groot, A.J.1
Mengesha, A.2
van der Wall, E.3
van Diest, P.J.4
Theys, J.5
Vooijs, M.6
-
64
-
-
84855275448
-
Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors
-
Krick E.L., Sorenmo K.U., Rankin S.C., Cheong I., Kobrin B., Thornton K., et al. Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors. Am J Vet Res 2012, 73:112-118.
-
(2012)
Am J Vet Res
, vol.73
, pp. 112-118
-
-
Krick, E.L.1
Sorenmo, K.U.2
Rankin, S.C.3
Cheong, I.4
Kobrin, B.5
Thornton, K.6
-
65
-
-
84907415255
-
Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
-
249ra111
-
Roberts N.J., Zhang L., Janku F., Collins A., Bai R.Y., Staedtke V., et al. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med 2014, 6. 249ra111.
-
(2014)
Sci Transl Med
, vol.6
-
-
Roberts, N.J.1
Zhang, L.2
Janku, F.3
Collins, A.4
Bai, R.Y.5
Staedtke, V.6
-
66
-
-
53249149260
-
A genetically enhanced anaerobic bacterium for oncopathic therapy of pancreatic cancer
-
Li Z., Fallon J., Mandeli J., Wetmur J., Woo S.L. A genetically enhanced anaerobic bacterium for oncopathic therapy of pancreatic cancer. J Natl Cancer Inst 2008, 100:1389-1400.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1389-1400
-
-
Li, Z.1
Fallon, J.2
Mandeli, J.3
Wetmur, J.4
Woo, S.L.5
-
67
-
-
84856037260
-
Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer
-
Maeda T., Murata M., Chiba H., Takasawa A., Tanaka S., Kojima T., et al. Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer. Prostate 2012, 72:351-360.
-
(2012)
Prostate
, vol.72
, pp. 351-360
-
-
Maeda, T.1
Murata, M.2
Chiba, H.3
Takasawa, A.4
Tanaka, S.5
Kojima, T.6
-
68
-
-
84862149017
-
Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors
-
Walther W., Petkov S., Kuvardina O.N., Aumann J., Kobelt D., Fichtner I., et al. Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors. Gene Ther 2012, 19:494-503.
-
(2012)
Gene Ther
, vol.19
, pp. 494-503
-
-
Walther, W.1
Petkov, S.2
Kuvardina, O.N.3
Aumann, J.4
Kobelt, D.5
Fichtner, I.6
-
69
-
-
1942501592
-
Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4
-
Kominsky S.L., Vali M., Korz D., Gabig T.G., Weitzman S.A., Argani P., et al. Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 2004, 164:1627-1633.
-
(2004)
Am J Pathol
, vol.164
, pp. 1627-1633
-
-
Kominsky, S.L.1
Vali, M.2
Korz, D.3
Gabig, T.G.4
Weitzman, S.A.5
Argani, P.6
-
70
-
-
0034837388
-
Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin
-
Michl P., Buchholz M., Rolke M., Kunsch S., Lohr M., McClane B., et al. Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology 2001, 121:678-684.
-
(2001)
Gastroenterology
, vol.121
, pp. 678-684
-
-
Michl, P.1
Buchholz, M.2
Rolke, M.3
Kunsch, S.4
Lohr, M.5
McClane, B.6
-
71
-
-
84878262797
-
Claudins overexpression in ovarian Cancer: potential targets for Clostridium perfringens enterotoxin (CPE) based diagnosis and therapy
-
English D.P., Santin A.D. Claudins overexpression in ovarian Cancer: potential targets for Clostridium perfringens enterotoxin (CPE) based diagnosis and therapy. Int J Mol Sci 2013, 14:10412-10437.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 10412-10437
-
-
English, D.P.1
Santin, A.D.2
-
72
-
-
0032851049
-
Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops
-
Sarker M.R., Carman R.J., McClane B.A. Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops. Mol Microbiol 1999, 33:946-958.
-
(1999)
Mol Microbiol
, vol.33
, pp. 946-958
-
-
Sarker, M.R.1
Carman, R.J.2
McClane, B.A.3
-
73
-
-
33750556169
-
Humans as reservoir for enterotoxin gene-carrying Clostridium perfringens type A
-
Heikinheimo A., Lindstrom M., Granum P.E., Korkeala H. Humans as reservoir for enterotoxin gene-carrying Clostridium perfringens type A. Emerg Infect Dis 2006, 12:1724-1729.
-
(2006)
Emerg Infect Dis
, vol.12
, pp. 1724-1729
-
-
Heikinheimo, A.1
Lindstrom, M.2
Granum, P.E.3
Korkeala, H.4
-
74
-
-
0032830180
-
Stable Escherichia coli-Clostridium acetobutylicum shuttle vector for secretion of murine tumor necrosis factor alpha
-
Theys J., Nuyts S., Landuyt W., Van Mellaert L., Dillen C., Bohringer M., et al. Stable Escherichia coli-Clostridium acetobutylicum shuttle vector for secretion of murine tumor necrosis factor alpha. Appl Environ Microbiol 1999, 65:4295-4300.
-
(1999)
Appl Environ Microbiol
, vol.65
, pp. 4295-4300
-
-
Theys, J.1
Nuyts, S.2
Landuyt, W.3
Van Mellaert, L.4
Dillen, C.5
Bohringer, M.6
-
75
-
-
18144385828
-
Secretory production of biologically active rat interleukin-2 by Clostridium acetobutylicum DSM792 as a tool for anti-tumor treatment
-
Barbe S., Van Mellaert L., Theys J., Geukens N., Lammertyn E., Lambin P., et al. Secretory production of biologically active rat interleukin-2 by Clostridium acetobutylicum DSM792 as a tool for anti-tumor treatment. FEMS Microbiol Lett 2005, 246:67-73.
-
(2005)
FEMS Microbiol Lett
, vol.246
, pp. 67-73
-
-
Barbe, S.1
Van Mellaert, L.2
Theys, J.3
Geukens, N.4
Lammertyn, E.5
Lambin, P.6
-
76
-
-
34548381342
-
Applications of bioluminescence imaging to the study of infectious diseases
-
Hutchens M., Luker G.D. Applications of bioluminescence imaging to the study of infectious diseases. Cell Microbiol 2007, 9:2315-2322.
-
(2007)
Cell Microbiol
, vol.9
, pp. 2315-2322
-
-
Hutchens, M.1
Luker, G.D.2
-
77
-
-
42049120034
-
Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals
-
Min J.J., Nguyen V.H., Kim H.J., Hong Y., Choy H.E. Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals. Nat Protoc 2008, 3:629-636.
-
(2008)
Nat Protoc
, vol.3
, pp. 629-636
-
-
Min, J.J.1
Nguyen, V.H.2
Kim, H.J.3
Hong, Y.4
Choy, H.E.5
-
79
-
-
1542336958
-
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
-
Yu Y.A., Shabahang S., Timiryasova T.M., Zhang Q., Beltz R., Gentschev I., et al. Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 2004, 22:313-320.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 313-320
-
-
Yu, Y.A.1
Shabahang, S.2
Timiryasova, T.M.3
Zhang, Q.4
Beltz, R.5
Gentschev, I.6
-
80
-
-
84880670005
-
Fusion of a flavin-based fluorescent protein to hydroxynitrile lyase from Arabidopsis thaliana improves enzyme stability
-
Scholz K.E., Kopka B., Wirtz A., Pohl M., Jaeger K.-E., Krauss U. Fusion of a flavin-based fluorescent protein to hydroxynitrile lyase from Arabidopsis thaliana improves enzyme stability. Appl Environ Microbiol 2013, 79:4727-4733.
-
(2013)
Appl Environ Microbiol
, vol.79
, pp. 4727-4733
-
-
Scholz, K.E.1
Kopka, B.2
Wirtz, A.3
Pohl, M.4
Jaeger, K.-E.5
Krauss, U.6
-
81
-
-
84888012495
-
Noninvasive imaging of infection after treatment with tumor-homing bacteria using chemical exchange saturation transfer (CEST) MRI
-
Liu G., Bettegowda C., Qiao Y., Staedtke V., Chan K.W., Bai R., et al. Noninvasive imaging of infection after treatment with tumor-homing bacteria using chemical exchange saturation transfer (CEST) MRI. Magn Reson Med: Off J Soc Magnetic Reson Med Soc Magn Reson Med 2013, 70:1690-1698.
-
(2013)
Magn Reson Med: Off J Soc Magnetic Reson Med Soc Magn Reson Med
, vol.70
, pp. 1690-1698
-
-
Liu, G.1
Bettegowda, C.2
Qiao, Y.3
Staedtke, V.4
Chan, K.W.5
Bai, R.6
-
82
-
-
33747141012
-
The use of clostridial spores for cancer treatment
-
Barbe S., Van Mellaert L., Anne J. The use of clostridial spores for cancer treatment. J Appl Microbiol 2006, 101:571-578.
-
(2006)
J Appl Microbiol
, vol.101
, pp. 571-578
-
-
Barbe, S.1
Van Mellaert, L.2
Anne, J.3
-
83
-
-
78650103296
-
Bacteriaas vectors for gene therapy of cancer
-
Baban C.K., Cronin M., O'Hanlon D., O'Sullivan G.C., Tangney M. Bacteriaas vectors for gene therapy of cancer. Bioeng Bugs 2010, 1:385-394.
-
(2010)
Bioeng Bugs
, vol.1
, pp. 385-394
-
-
Baban, C.K.1
Cronin, M.2
O'Hanlon, D.3
O'Sullivan, G.C.4
Tangney, M.5
-
84
-
-
33747090705
-
The study and treatment of cancer by proteolytic enzymes: preliminary report
-
Connell H.C. The study and treatment of cancer by proteolytic enzymes: preliminary report. Can Med Assoc J 1935, 33:364-370.
-
(1935)
Can Med Assoc J
, vol.33
, pp. 364-370
-
-
Connell, H.C.1
-
85
-
-
84928559047
-
Effect of histolyticus infection and toxin on transplantable mouse tumors
-
Parker R.C., Plummer H.C., Siebenmann C.O., Chapman M.G. Effect of histolyticus infection and toxin on transplantable mouse tumors. Proceedings of the society for experimental biology and medicine. Society for experimental biology and medicine (New York, NY), Royal Society of Medicine 1947, 461-467.
-
(1947)
Proceedings of the society for experimental biology and medicine. Society for experimental biology and medicine (New York, NY), Royal Society of Medicine
, pp. 461-467
-
-
Parker, R.C.1
Plummer, H.C.2
Siebenmann, C.O.3
Chapman, M.G.4
-
86
-
-
33747149297
-
Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration
-
Malmgren R.A., Flanigan C.C. Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration. Cancer Res 1955, 15:473-478.
-
(1955)
Cancer Res
, vol.15
, pp. 473-478
-
-
Malmgren, R.A.1
Flanigan, C.C.2
|