Development of a liposome formulation for improved biodistribution and tumor accumulation of pentamidine for oncology applications

International Journal of Pharmaceutics

Volumn 488, Issue 1-2, 2015, Pages 154-164

  Mérian, Juliette ^a,b   De Souza, Raquel ^a   Dou, Yannan ^a   Ekdawi, Sandra N ^a   Ravenelle, François ^b   Allen, Christine ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Drug delivery; Liposome; Pentamidine; Pharmacokinetics; Tumor accumulation

Indexed keywords

CHOLESTEROL; LIPOSOME; PENTAMIDINE ISETHIONATE; PHOSPHOLIPID; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; PENTAMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BREAST TUMOR; CANCER THERAPY; COLON TUMOR; COMPARATIVE STUDY; CONTROLLED STUDY; DIALYSIS MEMBRANE; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG RETENTION; DRUG STABILITY; DRUG STORAGE; DRUG TISSUE LEVEL; ENCAPSULATION; FEMALE; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; LIPOSOMAL DELIVERY; LUNG TUMOR; MAXIMUM PLASMA CONCENTRATION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR VOLUME; VOLUME OF DISTRIBUTION; ZETA POTENTIAL; ANIMAL; CHEMISTRY; HALF LIFE TIME; MEDICINAL CHEMISTRY; METABOLIC CLEARANCE RATE; PROCEDURES; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; DRUG LIBERATION; HALF-LIFE; LIPOSOMES; METABOLIC CLEARANCE RATE; MICE; PENTAMIDINE; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION;

EID: 84928491992     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.060     Document Type: Article

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