Enhanced localization of anticancer drug in tumor tissue using polyethylenimine-conjugated cationic liposomes

Nanoscale Research Letters

Volumn 9, Issue 1, 2014, Pages 1-6

  Han, Hee Dong ^a   Byeon, Yeongseon ^a   Jeon, Hat Nim ^a   Shin, Byung Cheol ^b  

^a Konkuk University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Liposome; Localization; Polyethylenimine; Tumor

Indexed keywords

CONTROLLED DRUG DELIVERY; MAMMALS; PARTICLE SIZE; TARGETED DRUG DELIVERY; TUMORS;

DRUG DELIVERY SYSTEM; INTRACELLULAR UPTAKE; INTRATUMORAL INJECTION; LIPOSOMAL MEMBRANES; LOCAL DRUG DELIVERY; LOCALIZATION; POLYETHYLENIMINES; SYSTEMIC DELIVERIES;

LIPOSOMES;

EID: 84903940811     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/1556-276X-9-209     Document Type: Article

References (29)

1. Allen TM, Cullis PR: Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 2012, 65: 36-48.
2. Safinya CR, Ewert KK: Materials chemistry: liposomes derived from molecular vases. Nature 2012, 489: 372-374.
3. Petersen AL, Hansen AE, Gabizon A, Andresen TL: Liposome imaging agents in personalized medicine. Adv Drug Deliv Rev 2012, 64: 1417-1435.
4. Moghimi SM, Szebeni J: Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res 2003, 42: 463-478.
5. Drummond DC, Meyer O, Hong K, Kirpotin DB, Papahadjopoulos D: Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 1999, 51: 691-743.
6. Jung SH, Kim SK, Kim EH, Cho SH, Jeong KS, Seong H, Shin BC: Increased stability in plasma and enhanced cellular uptake of thermally denatured albumin-coated liposomes. Colloids Surf B Biointerfaces 2010, 76: 434-440.
7. Han HD, Mora EM, Roh JW, Nishimura M, Lee SJ, Stone RL, Bar-Eli M, Lopez-Berestein G, Sood AK: Chitosan hydrogel for localized gene silencing. Cancer Biol Ther 2011, 11: 839-845.
8. Maitani Y, Ishigaki K, Nakazawa Y, Aragane D, Akimoto T, Iwamizu M, Kai T, Hayashi K: Polyethylenimine combined with liposomes and with decreased numbers of primary amine residues strongly enhanced therapeutic antiviral efficiency against herpes simplex virus type 2 in a mouse model. J Control Release 2013, 166: 139-146.
9. Perevyazko IY, Bauer M, Pavlov GM, Hoeppener S, Schubert S, Fischer D, Schubert US: Polyelectrolyte complexes of DNA and linear PEI: formation, composition and properties. Langmuir 2012, 28: 16167-16176.
10. Hu Y, Zhou D, Li C, Zhou H, Chen J, Zhang Z, Guo T: Gene delivery of PEI incorporating with functional block copolymer via non-covalent assembly strategy. Acta Biomater 2013, 9: 5003-5012.
11. Kim TW, Chung H, Kwon IC, Sung HC, Shin BC, Jeong SY: Polycations enhance emulsion-mediatedin vitroandin vivotransfection. Int J Pharm 2005, 295: 35-45.
12. Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL: Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res 2002, 62: 6831-6836.
13. Jung SH, Seong H, Cho SH, Jeong KS, Shin BC: Polyethylene glycol-complexed cationic liposome for enhanced cellular uptake and anticancer activity. Int J Pharm 2009, 382: 254-261.
14. Kim N, Jiang D, Jacobi AM, Lennox KA, Rose SD, Behlke MA, Salem AK: Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA. Int J Pharm 2012, 427: 123-133.
15. Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T: In vitrocytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24: 1121-1131.
16. Nimesh S, Chandra R: Polyethylenimine nanoparticles as an efficientin vitrosiRNA delivery system. Eur J Pharm Biopharm 2009, 73: 43-49.
17. Sabin J, Vazquez-Vazquez C, Prieto G, Bordi F, Sarmiento F: Double charge inversion in polyethylenimine-decorated liposomes. Langmuir 2012, 28: 10534-10542.
18. Huh MS, Lee SY, Park S, Lee S, Chung H, Choi Y, Oh YK, Park JH, Jeong SY, Choi K, Kim K, Kwon IC: Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice. J Control Release 2010, 144: 134-143.
19. Dempsey C, Lee I, Cowan KR, Suh J: Coating barium titanate nanoparticles with polyethylenimine improves cellular uptake and allows for coupled imaging and gene delivery. Colloids Surf B Biointerfaces 2013, 112: 108-112.
20. Seo DH, Shin BC, Kim MS: Preparation of cationic liposomes modified by polyethylenimine and their application as gene carrier. Polymer (Korea) 2005, 29: 277-281.
21. Haran G, Cohen R, Bar LK, Barenholz Y: Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993, 1151: 201-215.
22. Han HD, Lee A, Song CK, Hwang T, Seong H, Lee CO, Shin BC: In vivodistribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes. Int J Pharm 2006, 313: 181-188.
23. Li X, Hirsh DJ, Cabral-Lilly D, Zirkel A, Gruner SM, Janoff AS, Perkins WR: Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient. Biochim Biophys Acta 1998, 1415: 23-40.
24. Na K, Lee SA, Jung SH, Hyun J, Shin BC: Elastin-like polypeptide modified liposomes for enhancing cellular uptake into tumor cells. Colloids Surf B Biointerfaces 2012, 91: 130-136.
25. Hanzlikova M, Soininen P, Lampela P, Mannisto PT, Raasmaja A: The role of PEI structure and size in the PEI/liposome-mediated synergism of gene transfection. Plasmid 2009, 61: 15-21.
26. Jung SH, Na K, Lee SA, Cho SH, Seong H, Shin BC: Gd(iii)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging. Nanoscale Res Lett 2012, 7: 462-471.
27. Hwang T, Han HD, Song CK, Seong H, Kim JH, Chen X, Shin BC: Anticancer drug-phospholipid conjugate for enhancement of intracellular drug delivery. Macromol Symp 2007, 249-250: 109-115.
28. Xiong S, Yu B, Wu J, Li H, Lee RJ: Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-PEG-CHEMS. Biomed Pharmacother 2011, 65: 2-8.
29. Kluza E, Yeo SY, Schmid S, van der Schaft DW, Boekhoven RW, Schiffelers RM, Storm G, Strijkers GJ, Nicolay K: Anti-tumor activity of liposomal glucocorticoids: the relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity. J Control Release 2011, 151: 10-17.