Hemostasis and thrombosis in trauma patients

Seminars in Thrombosis and Hemostasis

Volumn 41, Issue 1, 2015, Pages 26-34

  Gando, Satoshi ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

acute coagulopathy trauma shock; coagulopathy; disseminated intravascular coagulation; fat embolism syndrome; fibrinolysis; trauma; traumatic brain injury

Indexed keywords

ACTIVATED PROTEIN C;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING DISORDER; DISSEMINATED INTRAVASCULAR CLOTTING; FAT EMBOLISM; FIBRINOLYSIS; HEMOSTASIS; HUMAN; INJURY; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; THROMBOSIS; TRAUMATIC BRAIN INJURY; BLOOD; BRAIN INJURY; PHYSIOLOGY;

BRAIN INJURIES; HEMOSTASIS; HUMANS; THROMBOSIS;

EID: 84928486509     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0034-1398378     Document Type: Article

References (98)

1. Levi M. Disseminated intravascular coagulation. Crit Care Med: 2007; 35 9 2191 2195
2. Gando S., Sawamura A., Hayakawa M. Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature. Ann Surg: 2011; 254 1 10 19
3. Engelmann B., Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol: 2013; 13 1 34 45
4. Hoffman M., Monroe D. M. III. A cell-based model of hemostasis. Thromb Haemost: 2001; 85 6 958 965
5. Gando S., Wada H., Kim H. K., et al. Scientific and Standardization Committee on DIC of the ISTH. Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock. J Thromb Haemost: 2012; 10 12 2593 2595
6. Gando S., Wada H., Thachil J.; Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH). Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). J Thromb Haemost: 2013; 11 5 826 835
7. Taylor F. B. Jr, Toh C. H., Hoots W. K., Wada H., Levi M.; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost: 2001; 86 5 1327 1330
8. Manson J., Thiemermann C., Brohi K. Trauma alarmins as activators of damage-induced inflammation. Br J Surg: 2012; 99 01 12 20
9. Cohen M. J., Brohi K., Calfee C. S., et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care: 2009; 13 6 R174
10. Kutcher M. E., Xu J., Vilardi R. F., Ho C., Esmon C. T., Cohen M. J. Extracellular histone release in response to traumatic injury: implications for compensatory role of activated protein C. J Trauma Acute Care Surg: 2012; 73 6 1389 1394
11. Abrams S. T., Zhang N., Manson J., et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med: 2013; 187 2 160 169
12. Zhang Q., Raoof M., Chen Y., et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature: 2010; 464 7285 104 107
13. Fuchs T. A., Bhandari A. A., Wagner D. D. Histones induce rapid and profound thrombocytopenia in mice. Blood: 2011; 118 13 3708 3714
14. Semeraro F., Ammollo C. T., Morrissey J. H., et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood: 2011; 118 7 1952 1961
15. Ammollo C. T., Semeraro F., Xu J., Esmon N. L., Esmon C. T. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost: 2011; 9 9 1795 1803
16. Ito T., Kawahara K., Nakamura T., et al. High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. J Thromb Haemost: 2007; 5 1 109 116
17. Gando S., Nakanishi Y., Tedo I. Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome. Crit Care Med: 1995; 23 11 1835 1842
18. Lenz A., Franklin G. A., Cheadle W. G. Systemic inflammation after trauma. Injury: 2007; 38 12 1336 1345
19. Esmon C. T. Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. Best Pract Res Clin Haematol: 1999; 12 3 343 359
20. Armstead V. E., Opentanova I. L., Minchenko A. G., Lefer A. M. Tissue factor expression in vital organs during murine traumatic shock: role of transcription factors AP-1 and NF-kappaB. Anesthesiology: 1999; 91 6 1844 1852
21. Hayakawa M., Sawamura A., Gando S., et al. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Surgery: 2011; 149 2 221 230
22. Yanagida Y., Gando S., Sawamura A., et al. Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock. Surgery: 2013; 154 1 48 57
23. Dunbar N. M., Chandler W. L. Thrombin generation in trauma patients. Transfusion: 2009; 49 12 2652 2660
24. Chandler W. L. Procoagulant activity in trauma patients. Am J Clin Pathol: 2010; 134 1 90 96
25. Ishii H., Majerus P. W. Thrombomodulin is present in human plasma and urine. J Clin Invest: 1985; 76 6 2178 2181
26. Ishii H., Uchiyama H., Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost: 1991; 65 5 618 623
27. Boehme M. WJ, Deng Y., Raeth U., et al. Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology: 1996; 87 1 134 140
28. Gando S., Nanzaki S., Morimoto Y., Ishitani T., Kemmotsu O. Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients. Crit Care Med: 2001; 29 2 262 266
29. Taylor F., Chang A., Ferrell G., et al. C4b-binding protein exacerbates the host response to Escherichia coli. Blood: 1991; 78 2 357 363
30. Engelman D. T., Gabram S. GA, Allen L., Ens G. E., Jacobs L. M. Hypercoagulability following multiple trauma. World J Surg: 1996; 20 1 5 10
31. Gando S., Nakanishi Y., Kameue T., Nanzaki S. Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase. J Trauma: 1995; 39 4 660 664
32. Gando S., Kameue T., Matsuda N., et al. Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma. Thromb Haemost: 2002; 88 6 943 949
33. Gando S., Tedo I., Kubota M. Posttrauma coagulation and fibrinolysis. Crit Care Med: 1992; 20 5 594 600
34. Oshiro A., Yanagida Y., Gando S., Henzan N., Takahashi I., Makise H. Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation. Crit Care: 2014; 18 2 R61
35. Marder V. J., Feinstein D. I., Colman R. W., Levi M. Consumptive thrombohemorrhagic disorders. In: Colman R. W., Marder V. J., Clowes A. W., George J. N., Goldhaber S. Z., eds. Hemostasis and Thrombosis. Basic Principles and Clinical Practice. 5th ed. Philadelphia, PA Lippincott Williams & Wilkins: 2006; 1571 1600
36. Lowenstein C. J., Morrell C. N., Yamakuchi M. Regulation of Weibel-Palade body exocytosis. Trends Cardiovasc Med: 2005; 15 8 302 308
37. Stump D. C., Taylor F. B. Jr, Nesheim M. E., Giles A. R., Dzik W. H., Bovill E. G. Pathologic fibrinolysis as a cause of clinical bleeding. Semin Thromb Hemost: 1990; 16 3 260 273
38. Suffredini A. F., Harpel P. C., Parrillo J. E. Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N Engl J Med: 1989; 320 18 1165 1172
39. Levi M., ten Cate H., van der Poll T., van Deventer S. J. Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA: 1993; 270 8 975 979
40. Gando S., Kameue T., Nanzaki S., Nakanishi Y. Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest. Thromb Haemost: 1997; 77 2 278 282
41. Gando S., Makise H., Tedo I. [Variation in wound healing factors in trauma patients]. Nippon Geka Gakkai Zasshi: 1990; 91 1 17 22
42. Gando S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit Care Med: 2010; 38 (2, Suppl): S35 S42
43. Hess J. R., Brohi K., Dutton R. P., et al. The coagulopathy of trauma: a review of mechanisms. J Trauma: 2008; 65 4 748 754
44. Brohi K., Cohen M. J., Ganter M. T., Matthay M. A., Mackersie R. C., Pittet J. F. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg: 2007; 245 5 812 818
45. Brohi K., Cohen M. J., Ganter M. T., et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma: 2008; 64 5 1211 1217, discussion 1217
46. Bouillon B., Brohi K., Hess J. R., Holcomb J. B., Parr M. J., Hoyt D. B. Educational initiative on critical bleeding in trauma: Chicago, July 11-13, 2008. J Trauma: 2010; 68 1 225 230
47. Frith D., Goslings J. C., Gaarder C., et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost: 2010; 8 9 1919 1925
48. Davenport R. Pathogenesis of acute traumatic coagulopathy. Transfusion: 2013; 53 01 23S 27S
49. Brohi K., Cohen M. J., Davenport R. A. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care: 2007; 13 6 680 685
50. Johansson P. I., Stensballe J., Rasmussen L. S., Ostrowski S. R. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg: 2011; 254 2 194 200
51. Noel P., Cashen S., Patel B. Trauma-induced coagulopathy: from biology to therapy. Semin Hematol: 2013; 50 3 259 269
52. Maegele M., Schöchl H., Cohen M. J. An update on the coagulopathy of trauma. Shock: 2014; 41 01 21 25
53. Gando S. Acute coagulopathy of trauma shock and coagulopathy of trauma: a rebuttal. You are now going down the wrong path. J Trauma: 2009; 67 2 381 383
54. Harhangi B. S., Kompanje E. JO, Leebeek F. WG, Maas A. I. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien): 2008; 150 2 165 175, discussion 175
55. Epstein D. S., Mitra B., O'Reilly G., Rosenfeld J. V., Cameron P. A. Acute traumatic coagulopathy in the setting of isolated traumatic brain injury: a systematic review and meta-analysis. Injury: 2014; 45 5 819 824
56. Kaufman H. H., Hui K. S., Mattson J. C., et al. Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury. Neurosurgery: 1984; 15 1 34 42
57. Stein S. C., Smith D. H. Coagulopathy in traumatic brain injury. Neurocrit Care: 2004; 1 4 479 488
58. Gando S., Nanzaki S., Kemmotsu O. Coagulofibrinolytic changes after isolated head injury are not different from those in trauma patients without head injury. J Trauma: 1999; 46 6 1070 1076, discussion 1076-1077
59. Drake T. A., Morrissey J. H., Edgington T. S. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol: 1989; 134 5 1087 1097
60. Osterud B., Bjorklid E. Sources of tissue factor. Semin Thromb Hemost: 2006; 32 1 11 23
61. Eddleston M., de la Torre J. C., Oldstone M. BA, Loskutoff D. J., Edgington T. S., Mackman N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. J Clin Invest: 1993; 92 1 349 358
62. Zhang J., Jiang R., Liu L., Watkins T., Zhang F., Dong J. F. Traumatic brain injury-associated coagulopathy. J Neurotrauma: 2012; 29 17 2597 2605
63. Kumar M. A. Coagulopathy associated with traumatic brain injury. Curr Neurol Neurosci Rep: 2013; 13 11 391
64. McClain C. J., Cohen D., Ott L., Dinarello C. A., Young B. Ventricular fluid interleukin-1 activity in patients with head injury. J Lab Clin Med: 1987; 110 1 48 54
65. McClain C., Cohen D., Phillips R., Ott L., Young B. Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury. J Lab Clin Med: 1991; 118 3 225 231
66. Goodman J. C., Robertson C. S., Grossman R. G., Narayan R. K. Elevation of tumor necrosis factor in head injury. J Neuroimmunol: 1990; 30 2-3 213 217
67. Bellander B. M., Singhrao S. K., Ohlsson M., Mattsson P., Svensson M. Complement activation in the human brain after traumatic head injury. J Neurotrauma: 2001; 18 12 1295 1311
68. Keimowitz R. M., Annis B. L. Disseminated intravascular coagulation associated with massive brain injury. J Neurosurg: 1973; 39 2 178 180
69. Touho H., Hirakawa K., Hino A., Karasawa J., Ohno Y. Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury. Neurosurgery: 1986; 19 4 523 531
70. Scherer R. U., Spangenberg P. Procoagulant activity in patients with isolated severe head trauma. Crit Care Med: 1998; 26 1 149 156
71. Murshid W. R., Gader A. GMA. The coagulopathy in acute head injury: comparison of cerebral versus peripheral measurements of haemostatic activation markers. Br J Neurosurg: 2002; 16 4 362 369
72. Nekludov M., Antovic J., Bredbacka S., Blombäck M. Coagulation abnormalities associated with severe isolated traumatic brain injury: cerebral arterio-venous differences in coagulation and inflammatory markers. J Neurotrauma: 2007; 24 1 174 180
73. Morel N., Morel O., Petit L., et al. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma: 2008; 64 3 698 704
74. Carrick M. M., Tyroch A. H., Youens C. A., Handley T. Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J Trauma: 2005; 58 4 725 729, discussion 729-730
75. Owings J. T., Gosselin R. Acquired antithrombin deficiency following severe traumatic injury: rationale for study of antithrombin supplementation. Semin Thromb Hemost: 1997; 23 01 17 24
76. Wu X. H., Shi X. Y., Gan J. X., Lu X. G., Jiang G. Y., Zhou J. F. Dynamically monitoring tissue factor and tissue factor pathway inhibitor following secondary brain injury. Chin J Traumatol: 2003; 6 2 114 117
77. Lustenberger T., Talving P., Kobayashi L., et al. Early coagulopathy after isolated severe traumatic brain injury: relationship with hypoperfusion challenged. J Trauma: 2010; 69 6 1410 1414
78. Cohen M. J., Brohi K., Ganter M. T., Manley G. T., Mackersie R. C., Pittet J. F. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma: 2007; 63 6 1254 1261, discussion 1261-1262
79. Clark J. A., Finelli R. E., Netsky M. G. Disseminated intravascular coagulation following cranial trauma. Case report. J Neurosurg: 1980; 52 2 266 269
80. Stein S. C., Chen X. H., Sinson G. P., Smith D. H. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J Neurosurg: 2002; 97 6 1373 1377
81. Stein S. C., Graham D. I., Chen X. H., Smith D. H. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery: 2004; 54 3 687 691, discussion 691
82. Schwarzmaier S. M., Kim S. W., Trabold R., Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J Neurotrauma: 2010; 27 1 121 130
83. Kushimoto S., Yamamoto Y., Shibata Y., Sato H., Koido Y. Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery: 2001; 49 5 1084 1089, discussion 1089-1090
84. Okajima K., Kohno I., Soe G., Okabe H., Takatsuki K., Binder B. R. Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency. Am J Hematol: 1994; 45 1 16 24
85. Kumura E., Sato M., Fukuda A., Takemoto Y., Tanaka S., Kohama A. Coagulation disorders following acute head injury. Acta Neurochir (Wien): 1987; 85 1-2 23 28
86. Lemarchant S., Docagne F., Emery E., Vivien D., Ali C., Rubio M. tPA in the injured central nervous system: different scenarios starring the same actor? Neuropharmacology: 2012; 62 2 749 756
87. Tovi D. Fibrinolytic activity of human brain. A histochemical study. Acta Neurol Scand: 1973; 49 2 152 162
88. Sashindranath M., Samson A. L., Downes C. E., et al. Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation. Lab Invest: 2011; 91 7 1079 1091
89. Mellor A., Soni N. Fat embolism. Anaesthesia: 2001; 56 2 145 154
90. Bergentz S. E., Nilsson I. M. Effect of trauma on coagulation and fibrinolysis in dogs. Acta Chir Scand: 1961; 122 21 29
91. Riseborough E. J., Herndon J. H. Alterations in pulmonary function, coagulation and fat metabolism in patients with fractures of the lower limbs. Clin Orthop Relat Res: 1976; 115 248 267
92. Shier M. R., Wilson R. F. Fat embolism syndrome: traumatic coagulopathy with respiratory distress. Surg Annu: 1980; 12 139 168
93. Saldeen T. Fat embolism and signs of intravascular coagulation in a posttraumatic autopsy material. J Trauma: 1970; 10 4 273 286
94. Miller P., Prahlow J. A. Autopsy diagnosis of fat embolism syndrome. Am J Forensic Med Pathol: 2011; 32 3 291 299
95. Saldeen T. The importance of intravascular coagulation and inhibition of the fibrinolytic system in experimental fat embolism. J Trauma: 1970; 10 4 287 298
96. Kao S. J., Yeh D. YW, Chen H. I. Clinical and pathological features of fat embolism with acute respiratory distress syndrome. Clin Sci (Lond): 2007; 113 6 279 285
97. Serck-Hanssen A. Posttraumatic fat embolism. Red cell aggregation, hyaline microthrombi and platelet aggregates in 5 fatal cases. Acta Pathol Microbiol Scand: 1965; 65 31 45
98. Arai F., Kita T., Nakai T., et al. Histopathologic features of fat embolism in fulminant fat embolism syndrome. Anesthesiology: 2007; 107 3 509 511