메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA1 INTEGRIN; FOCAL ADHESION KINASE; PACLITAXEL;

EID: 84928485063     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09529     Document Type: Article
Times cited : (61)

References (70)
  • 3
    • 78650752224 scopus 로고    scopus 로고
    • Clinical trials and progress with paclitaxel in ovarian cancer
    • Kumar, S. et al. Clinical trials and progress with paclitaxel in ovarian cancer. Int. J. Womens. Health 2, 411-27 (2010).
    • (2010) Int. J. Womens. Health , vol.2 , pp. 411-427
    • Kumar, S.1
  • 4
    • 84875690627 scopus 로고    scopus 로고
    • Latest research and treatment of advanced-stage epithelial ovarian cancer
    • Coleman, R., Monk, B., Sood, A. & Herzog, T. Latest research and treatment of advanced-stage epithelial ovarian cancer. Nat. Rev. Clin. Oncol. 10, 211-224 (2013).
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 211-224
    • Coleman, R.1    Monk, B.2    Sood, A.3    Herzog, T.4
  • 5
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: Strategies for overcoming resistance to chemotherapy
    • Agarwal, R. & Kaye, S. B. Ovarian cancer: Strategies for overcoming resistance to chemotherapy. Nat. Rev. Cancer 3, 502-16 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 6
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris, M. Microtubules and resistance to tubulin-binding agents. Nat. Rev. Cancer 10, 194-204 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 194-204
    • Kavallaris, M.1
  • 7
    • 0027829631 scopus 로고
    • Taxol: Mechanisms of action and resistance
    • Horwitz, S. B. et al. Taxol: Mechanisms of action and resistance. J. Natl. Cancer Inst. Monogr. 15, 55-61 (1993).
    • (1993) J. Natl. Cancer Inst. Monogr. , vol.15 , pp. 55-61
    • Horwitz, S.B.1
  • 8
    • 58149178732 scopus 로고    scopus 로고
    • A proteomic approach to paclitaxel chemoresistance in ovarian cancer cell lines
    • Di Michele, M. et al. A proteomic approach to paclitaxel chemoresistance in ovarian cancer cell lines. Biochim. Biophys. Acta 1794, 225-36 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 225-236
    • Di Michele, M.1
  • 9
    • 0035949576 scopus 로고    scopus 로고
    • Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics
    • Gonçalves, A. et al. Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc. Natl. Acad. Sci. U. S. A. 98, 11737-42 (2001).
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 11737-11742
    • Gonçalves, A.1
  • 10
    • 0030931827 scopus 로고    scopus 로고
    • Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific b-tubulin isotypes
    • Kavallaris, M. et al. Taxol-resistant Epithelial Ovarian Tumors Are Associated with Altered Expression of Specific B-Tubulin Isotypes. J. Clin. Invest 100, 1282-1293 (1997).
    • (1997) J. Clin. Invest , vol.100 , pp. 1282-1293
    • Kavallaris, M.1
  • 11
    • 0019827946 scopus 로고
    • Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin
    • Cabral, F. Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin. Proc. Natl. Acad. Sci. 78, 4388-4391 (1981).
    • (1981) Proc. Natl. Acad. Sci. , vol.78 , pp. 4388-4391
    • Cabral, F.1
  • 12
    • 84899056961 scopus 로고    scopus 로고
    • Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles
    • Zasadil, L. M. et al. Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles. Sci. Transl. Med. 6, 229ra43-229ra43 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 22943-22943
    • Zasadil, L.M.1
  • 13
    • 79959636906 scopus 로고    scopus 로고
    • The physics of cancer: The role of physical interactions and mechanical forces in metastasis
    • Wirtz, D., Konstantopoulos, K. & Searson, P. C. The physics of cancer: The role of physical interactions and mechanical forces in metastasis. Nat. Rev. Cancer 11, 512-22 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 512-522
    • Wirtz, D.1    Konstantopoulos, K.2    Searson, P.C.3
  • 14
    • 35148825636 scopus 로고    scopus 로고
    • Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    • Kajiyama, H. et al. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int. J. Oncol. 31, 277-83 (2007).
    • (2007) Int. J. Oncol. , vol.31 , pp. 277-283
    • Kajiyama, H.1
  • 15
    • 41849105806 scopus 로고    scopus 로고
    • The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    • Kenny, H. & Kaur, S. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J. Clin. Invest 118, 1367-1379 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 1367-1379
    • Kenny, H.1    Kaur, S.2
  • 17
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier, J. S. & Cheresh, D. A. Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 10, 9-22 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 18
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of akt2/protein kinase b{beta} leads to up-regulation of {beta}1 integrins increased invasion and metastasis of human breast and ovarian cancer cells
    • Arboleda, M. J. et al. Overexpression of AKT2/Protein Kinase B{beta} Leads to Up-Regulation of {beta}1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells. Cancer Res. 63, 196-206 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 196-206
    • Arboleda, M.J.1
  • 19
    • 0032588084 scopus 로고    scopus 로고
    • Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro
    • Strobel, T. & Cannistra, S. A. Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro. Gynecol. Oncol. 73, 362-7 (1999).
    • (1999) Gynecol. Oncol. , vol.73 , pp. 362-367
    • Strobel, T.1    Cannistra, S.A.2
  • 20
    • 60549088136 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis
    • Slack-Davis, J. K., Atkins, K. A., Harrer, C., Hershey, E. D. & Conaway, M. Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res. 69, 1469-76 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1469-1476
    • Slack-Davis, J.K.1    Atkins, K.A.2    Harrer, C.3    Hershey, E.D.4    Conaway, M.5
  • 21
    • 55849128163 scopus 로고    scopus 로고
    • Tumor-selective response to antibody-mediated targeting of a v b 3 integrin in Ovarian Cancer
    • Landen, C., Kim, T., Lin, Y.&Merritt, W. Tumor-Selective Response to Antibody-Mediated Targeting of a v b 3 Integrin in Ovarian Cancer. Neoplasia 10, 1259-1267 (2008).
    • (2008) Neoplasia , vol.10 , pp. 1259-1267
    • Landen, C.1    Kim, T.2    Lin, Y.3    Merritt, W.4
  • 22
    • 0842331443 scopus 로고    scopus 로고
    • Localized stabilization of microtubules by integrin-and FAK-facilitated Rho signaling
    • Palazzo, A. F., Eng,C.H., Schlaepfer, D. D.,Marcantonio, E. E.&Gundersen,G.G. Localized stabilization of microtubules by integrin-and FAK-facilitated Rho signaling. Science 303, 836-9 (2004).
    • (2004) Science , vol.303 , pp. 836-839
    • Palazzo, A.F.1    Eng, C.H.2    Schlaepfer, D.D.3    Marcantonio, E.E.4    Gundersen, G.G.5
  • 23
    • 40549121603 scopus 로고    scopus 로고
    • Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites
    • Efimov, A. et al. Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J. Cell Sci. 121, 405-405 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 405-405
    • Efimov, A.1
  • 25
    • 0031036695 scopus 로고    scopus 로고
    • P53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel
    • Debernardis, D., Siré, E. & Feudis, P. De. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res. 57, 870-874 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 870-874
    • Debernardis, D.1    Siré, E.2    De, F.P.3
  • 26
    • 0034893953 scopus 로고    scopus 로고
    • Kinetics of P-glycoprotein-mediated efflux of paclitaxel
    • Jang, S. H.,Wientjes, M. G. & Au, J. L. Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J. Pharmacol. Exp. Ther. 298, 1236-42 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 1236-1242
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.L.3
  • 27
    • 77956340867 scopus 로고    scopus 로고
    • Analysis of microtubule dynamic instability using a plus-end growth marker
    • Matov, A. et al. Analysis of microtubule dynamic instability using a plus-end growth marker. Nat. Methods 7, 761-8 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 761-768
    • Matov, A.1
  • 28
    • 20444370219 scopus 로고    scopus 로고
    • Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
    • Ezratty, E. J., Partridge, M. A. & Gundersen, G. G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 7, 581-90 (2005).
    • (2005) Nat. Cell Biol. , vol.7 , pp. 581-590
    • Ezratty, E.J.1    Partridge, M.A.2    Gundersen, G.G.3
  • 29
    • 84863184171 scopus 로고    scopus 로고
    • Microtubule depolymerization induces traction force increase through two distinct pathways
    • Rape, A., Guo, W. & Wang, Y. Microtubule depolymerization induces traction force increase through two distinct pathways. J. Cell Sci. 124, 4233-40 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 4233-4240
    • Rape, A.1    Guo, W.2    Wang, Y.3
  • 30
    • 84899491548 scopus 로고    scopus 로고
    • Microtubules Mechanically Regulate Cell Adhesion Strengthening Via Cell Shape
    • Elineni, K. K. &Gallant, N. D. Microtubules Mechanically Regulate Cell Adhesion Strengthening Via Cell Shape. Cell. Mol. Bioeng. 7, 136-144 (2013).
    • (2013) Cell. Mol. Bioeng. , vol.7 , pp. 136-144
    • Elineni, K.K.1    Gallant, N.D.2
  • 31
    • 0030266491 scopus 로고    scopus 로고
    • Involvement of microtubules in the control of adhesion-dependent signal transduction
    • Bershadsky, A., Chausovsky, A., Becker, E., Lyubimova, A. & Geiger, B. Involvement of microtubules in the control of adhesion-dependent signal transduction. Curr. Biol. 6, 1279-89 (1996).
    • (1996) Curr. Biol. , vol.6 , pp. 1279-1289
    • Bershadsky, A.1    Chausovsky, A.2    Becker, E.3    Lyubimova, A.4    Geiger, B.5
  • 32
    • 2442606429 scopus 로고    scopus 로고
    • Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility
    • Subauste, M. C. et al. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J. Cell Biol. 165, 371-81 (2004).
    • (2004) J. Cell Biol. , vol.165 , pp. 371-381
    • Subauste, M.C.1
  • 33
    • 0035858878 scopus 로고    scopus 로고
    • Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts
    • Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V. &Wang, Y. L. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell Biol. 153, 881-8 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 881-888
    • Beningo, K.A.1    Dembo, M.2    Kaverina, I.3    Small, J.V.4    Wang, Y.L.5
  • 34
    • 34447538483 scopus 로고    scopus 로고
    • Cellular characterization of a novel focal adhesion kinase inhibitor
    • Slack-Davis, J. K. et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J. Biol. Chem. 282, 14845-52 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 14845-14852
    • Slack-Davis, J.K.1
  • 35
    • 12444303179 scopus 로고    scopus 로고
    • Description of paclitaxel resistance-associated genes in ovarian and breast cancer cell lines
    • Duan, Z., Lamendola, D. E., Duan, Y., Yusuf, R. Z. & Seiden, M. V. Description of paclitaxel resistance-associated genes in ovarian and breast cancer cell lines. Cancer Chemother. Pharmacol. 55, 277-85 (2005).
    • (2005) Cancer Chemother. Pharmacol. , vol.55 , pp. 277-285
    • Duan, Z.1    Lamendola, D.E.2    Duan, Y.3    Yusuf, R.Z.4    Seiden, M.V.5
  • 36
    • 0035876393 scopus 로고    scopus 로고
    • Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: A gynecologic oncology group study
    • Fracasso, P. M. et al. Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: A gynecologic oncology group study. J. Clin. Oncol. 19, 2975-82 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2975-2982
    • Fracasso, P.M.1
  • 37
    • 1842477895 scopus 로고    scopus 로고
    • Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: A study in serial samples
    • Penson, R. T. et al. Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: A study in serial samples. Gynecol. Oncol. 93, 98-106 (2004).
    • (2004) Gynecol. Oncol. , vol.93 , pp. 98-106
    • Penson, R.T.1
  • 38
    • 0031581815 scopus 로고    scopus 로고
    • Acquisition of taxol resistance via Pglycoprotein-and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells
    • Parekh, H., Wiesen, K. & Simpkins, H. Acquisition of taxol resistance via Pglycoprotein-and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells. Biochem. Pharmacol. 53, 461-70 (1997).
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 461-470
    • Parekh, H.1    Wiesen, K.2    Simpkins, H.3
  • 39
    • 0345688612 scopus 로고    scopus 로고
    • Mechanisms of Taxol resistance related to microtubules
    • Orr, G. A., Verdier-Pinard, P., McDaid, H. & Horwitz, S. B. Mechanisms of Taxol resistance related to microtubules. Oncogene 22, 7280-95 (2003).
    • (2003) Oncogene , vol.22 , pp. 7280-7295
    • Orr, G.A.1    Verdier-Pinard, P.2    McDaid, H.3    Horwitz, S.B.4
  • 40
    • 0032872870 scopus 로고    scopus 로고
    • Microtubule Targeting of Substrate Contacts Promotes Their Relaxation
    • Kaverina, I., Krylyshkina, O. & Small, J. V. Microtubule Targeting of Substrate Contacts Promotes Their Relaxation. J. Cell Biol. 146, 1033-1043 (1999).
    • (1999) J. Cell Biol. , vol.146 , pp. 1033-1043
    • Kaverina, I.1    Krylyshkina, O.2    Small, J.V.3
  • 41
    • 84901819506 scopus 로고    scopus 로고
    • CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover
    • Stehbens, S. J. et al. CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat. Cell Biol. 16, (2014).
    • (2014) Nat. Cell Biol. , vol.16
    • Stehbens, S.J.1
  • 42
    • 0029657597 scopus 로고    scopus 로고
    • Paclitaxel (Taxol(R)) inhibits motility of paclitaxel-resistant human ovarian carcinoma cells
    • Belotti, D. et al. Paclitaxel (Taxol(R)) inhibits motility of paclitaxel-resistant human ovarian carcinoma cells. Clin. Cancer Res. 2, 1725-30 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1725-1730
    • Belotti, D.1
  • 43
    • 65649135420 scopus 로고    scopus 로고
    • Focal adhesion kinase modulates cell adhesion strengthening via integrin activation
    • Michael, K. E., Dumbauld, D.W., Burns, K. L., Hanks, S. K. & García, A. J. Focal adhesion kinase modulates cell adhesion strengthening via integrin activation. Mol. Biol. Cell 20, 2508-19 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2508-2519
    • Michael, K.E.1    Dumbauld, D.W.2    Burns, K.L.3    Hanks, S.K.4    García, A.J.5
  • 44
    • 27144559204 scopus 로고    scopus 로고
    • Quantification of microtubule nucleation, growth and dynamics in wound-edge cells
    • Salaycik, K. J., Fagerstrom, C. J., Murthy, K., Tulu, U. S. & Wadsworth, P. Quantification of microtubule nucleation, growth and dynamics in wound-edge cells. J. Cell Sci. 118, 4113-22 (2005).
    • (2005) J. Cell Sci. , vol.118 , pp. 4113-4122
    • Salaycik, K.J.1    Fagerstrom, C.J.2    Murthy, K.3    Tulu, U.S.4    Wadsworth, P.5
  • 45
    • 57349135304 scopus 로고    scopus 로고
    • Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer
    • Horiuchi, A. et al. Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer. Cancer Sci. 99, 2532-9 (2008).
    • (2008) Cancer Sci. , vol.99 , pp. 2532-2539
    • Horiuchi, A.1
  • 46
    • 24344434553 scopus 로고    scopus 로고
    • Cell adhesion strengthening: Contributions of adhesive area, integrin binding, and focal adhesion assembly
    • Gallant, N.,Michael, K.&García, A. Cell adhesion strengthening: Contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol. Biol. Cell 16, 4329-4340 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4329-4340
    • Gallant, N.1    Michael, K.2    García, A.3
  • 47
    • 33947716334 scopus 로고    scopus 로고
    • Model of integrin-mediated cell adhesion strengthening
    • Gallant, N. D. & García, A. J. Model of integrin-mediated cell adhesion strengthening. J. Biomech. 40, 1301-9 (2007).
    • (2007) J. Biomech. , vol.40 , pp. 1301-1309
    • Gallant, N.D.1    García, A.J.2
  • 48
    • 77951184829 scopus 로고    scopus 로고
    • Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions
    • Schaller, M. D. Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions. J. Cell Sci. 123, 1007-13 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 1007-1013
    • Schaller, M.D.1
  • 49
    • 1642586962 scopus 로고    scopus 로고
    • FAK-Src signalling through paxillin ERK and MLCK regulates adhesion disassembly
    • Webb, D. J. et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6, 154-61 (2004).
    • (2004) Nat. Cell Biol. , vol.6 , pp. 154-161
    • Webb, D.J.1
  • 50
    • 29344471438 scopus 로고    scopus 로고
    • Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells
    • Halder, J. et al. Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin. Cancer Res. 11, 8829-36 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8829-8836
    • Halder, J.1
  • 51
    • 84885440374 scopus 로고    scopus 로고
    • Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    • Kang, Y. et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J. Natl. Cancer Inst. 105, 1485-95 (2013).
    • (2013) J. Natl. Cancer Inst. , vol.105 , pp. 1485-1495
    • Kang, Y.1
  • 52
    • 4644315256 scopus 로고    scopus 로고
    • Biological significance of focal adhesion kinase in ovarian cancer: Role in migration and invasion
    • Sood, A., Coffin, J. & Schneider, G. Biological significance of focal adhesion kinase in ovarian cancer: Role in migration and invasion. Am. J. Pathol. 165, 1087-1095 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 1087-1095
    • Sood, A.1    Coffin, J.2    Schneider, G.3
  • 53
    • 77449141217 scopus 로고    scopus 로고
    • IntOGen: Integration and data mining of multidimensional oncogenomic data
    • Gundem, G. et al. IntOGen: Integration and data mining of multidimensional oncogenomic data. Nat. Methods 7, 92-3 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 92-93
    • Gundem, G.1
  • 54
    • 84862990976 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and pharmacodynamic phase i doseescalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors
    • Infante, J. R. et al. Safety, pharmacokinetic, and pharmacodynamic phase I doseescalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J. Clin. Oncol. 30, 1527-33 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1527-1533
    • Infante, J.R.1
  • 55
    • 33745245989 scopus 로고    scopus 로고
    • Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration
    • Gupton, S. L. & Waterman-Storer, C. M. Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell 125, 1361-74 (2006).
    • (2006) Cell , vol.125 , pp. 1361-1374
    • Gupton, S.L.1    Waterman-Storer, C.M.2
  • 56
    • 80053169555 scopus 로고    scopus 로고
    • Ovarian cancer spheroids use myosin-generated force to clear the mesothelium
    • Iwanicki, M. et al. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 1, 144-157 (2011).
    • (2011) Cancer Discov. , vol.1 , pp. 144-157
    • Iwanicki, M.1
  • 57
    • 84894078697 scopus 로고    scopus 로고
    • Inhibition of a4b1 integrin increases ovarian cancer response to carboplatin
    • Scalici, J. M. et al. Inhibition of a4b1 integrin increases ovarian cancer response to carboplatin. Gynecol. Oncol. 132, 455-61 (2014).
    • (2014) Gynecol. Oncol. , vol.132 , pp. 455-461
    • Scalici, J.M.1
  • 58
    • 38449113305 scopus 로고    scopus 로고
    • Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance
    • Zutter, M. M. Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance. Adv. Exp. Med. Biol. 608, 87-100 (2007).
    • (2007) Adv. Exp. Med. Biol. , vol.608 , pp. 87-100
    • Zutter, M.M.1
  • 59
    • 2942561951 scopus 로고    scopus 로고
    • High expression of integrin beta1 and p53 is a greater poor prognostic factor than clinical stage in small-cell lung cancer
    • Oshita, F. et al. High expression of integrin beta1 and p53 is a greater poor prognostic factor than clinical stage in small-cell lung cancer. Am. J. Clin. Oncol. 27, 215-9 (2004).
    • (2004) Am. J. Clin. Oncol. , vol.27 , pp. 215-219
    • Oshita, F.1
  • 60
    • 77953811126 scopus 로고    scopus 로고
    • Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrinmediated focal adhesion kinase and Akt activation
    • Lane, D., Goncharenko-Khaider, N., Rancourt, C. & Piché, A. Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrinmediated focal adhesion kinase and Akt activation. Oncogene 29, 3519-31 (2010).
    • (2010) Oncogene , vol.29 , pp. 3519-3531
    • Lane, D.1    Goncharenko-Khaider, N.2    Rancourt, C.3    Piché, A.4
  • 61
    • 20444448808 scopus 로고    scopus 로고
    • An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines
    • Smith, J. A., Ngo, H., Martin, M. C. & Wolf, J. K. An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines. Gynecol. Oncol. 98, 141-5 (2005).
    • (2005) Gynecol. Oncol. , vol.98 , pp. 141-145
    • Smith, J.A.1    Ngo, H.2    Martin, M.C.3    Wolf, J.K.4
  • 62
    • 84873994986 scopus 로고    scopus 로고
    • Biomechanical analysis predicts decreased human mesenchymal stem cell function before molecular differences
    • McGrail, D. J., McAndrews, K. M. & Dawson, M. R. Biomechanical analysis predicts decreased human mesenchymal stem cell function before molecular differences. Exp. Cell Res. 319, 684-96 (2013).
    • (2013) Exp. Cell Res. , vol.319 , pp. 684-696
    • McGrail, D.J.1    McAndrews, K.M.2    Dawson, M.R.3
  • 63
    • 84883345978 scopus 로고    scopus 로고
    • Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting
    • Eaton, S. L. et al. Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PLoS One 8, e72457 (2013).
    • (2013) PLoS One , vol.8 , pp. e72457
    • Eaton, S.L.1
  • 64
    • 79952400632 scopus 로고    scopus 로고
    • Coomassie staining as loading control inWestern blot analysis
    • Welinder, C. & Ekblad, L. Coomassie staining as loading control inWestern blot analysis. J. Proteome Res. 10, 1416-9 (2011).
    • (2011) J. Proteome Res. , vol.10 , pp. 1416-1419
    • Welinder, C.1    Ekblad, L.2
  • 65
    • 0025872827 scopus 로고
    • Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin
    • Minotti, A., Barlow, S. & Cabral, F. Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin. J. Biol. Chem. 266, 3987-3994 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 3987-3994
    • Minotti, A.1    Barlow, S.2    Cabral, F.3
  • 66
    • 84858422884 scopus 로고    scopus 로고
    • Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors
    • McGrail, D. J., Ghosh, D., Quach, N. D. & Dawson, M. R. Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors. PLoS One 7, e33248 (2012).
    • (2012) PLoS One , vol.7 , pp. e33248
    • McGrail, D.J.1    Ghosh, D.2    Quach, N.D.3    Dawson, M.R.4
  • 67
    • 48449087576 scopus 로고    scopus 로고
    • Robust single-particle tracking in live-cell time-lapse sequences
    • Jaqaman, K., Loerke, D. & Mettlen, M. Robust single-particle tracking in live-cell time-lapse sequences. Nat. Methods 5, 695-702 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 695-702
    • Jaqaman, K.1    Loerke, D.2    Mettlen, M.3
  • 68
    • 84931293613 scopus 로고    scopus 로고
    • SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression
    • McGrail, D. J., Mezencev, R., Kieu, Q. M. N., McDonald, J. F. & Dawson, M. R. SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression. FASEB J. doi:10.1096/fj.14-257345 (2014).
    • (2014) FASEB J.
    • McGrail, D.J.1    Mezencev, R.2    Kieu, Q.M.N.3    McDonald, J.F.4    Dawson, M.R.5
  • 69
    • 84902491208 scopus 로고    scopus 로고
    • The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway
    • McGrail, D. J., Kieu, Q. M. N. & Dawson, M. R. The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway. J. Cell Sci. 127, 2621-6 (2014).
    • (2014) J. Cell Sci. , vol.127 , pp. 2621-2626
    • McGrail, D.J.1    Kieu, Q.M.N.2    Dawson, M.R.3
  • 70
    • 37749000819 scopus 로고    scopus 로고
    • High resolution traction force microscopy based on experimental and computational advances
    • Sabass, B., Gardel, M. L., Waterman, C. M. & Schwarz, U. S. High resolution traction force microscopy based on experimental and computational advances. Biophys. J. 94, 207-20 (2008).
    • (2008) Biophys. J. , vol.94 , pp. 207-220
    • Sabass, B.1    Gardel, M.L.2    Waterman, C.M.3    Schwarz, U.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.