Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest

Shock

Volumn 43, Issue 5, 2015, Pages 490-496

  Xie, Xuemeng ^a   Zhang, Jincheng ^a   Chen, Di ^a   Pan, Hao ^a   Wu, Ziqian ^a   Ge, Dong ^a   Yang, Guangtian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

apoptosis; brain injury; cardiac arrest; cardiopulmonary resuscitation; Ghrelin; uncoupling protein 2

Indexed keywords

ADRENALIN; CASPASE 3; GHRELIN; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; UNCOUPLING PROTEIN 2; ALDEHYDE; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; ION CHANNEL; MALEALDEHYDE; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIAL GAS; ARTICLE; ARTIFICIAL VENTILATION; BRAIN HISTOLOGY; BRAIN INJURY; BRAIN TISSUE; CELL VIABILITY; CONTROLLED STUDY; HEART ARREST; HIPPOCAMPAL CA1 REGION; MEAN ARTERIAL PRESSURE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; POSTRESUSCITATION BRAIN INJURY; PROTEIN EXPRESSION; RAT; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; ANIMAL; BRAIN INJURIES; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

ALDEHYDES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN INJURIES; CA1 REGION, HIPPOCAMPAL; CARDIOPULMONARY RESUSCITATION; CASPASE 3; CELL SURVIVAL; GHRELIN; HEART ARREST; ION CHANNELS; MITOCHONDRIAL PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TIME FACTORS; UP-REGULATION;

EID: 84928481860     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000337     Document Type: Article

References (35)

1. Laver S, Farrow C, Turner D, Nolan J: Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 30(11): 2126-2128, 2004.
2. Polanowska KE, Sarzynska-Dlugosz IM, Paprot AE, Sikorska S, Seniow JB, Karpinski G, Kowalik R, Opolski G, Czlonkowska A: Neuropsychological and neurological sequelae of out-of-hospital cardiac arrest and the estimated need for neurorehabilitation: a prospective pilot study. Kardiol Pol 72(9):814-822, 2014.
3. van Alem AP, de Vos R, Schmand B, Koster RW: Cognitive impairment in survivors of out-of-hospital cardiac arrest. Am Heart J 148(3):416-421, 2004.
4. Lim C, Alexander MP, LaFleche G, Schnyer DM, Verfaellie M: The neurological and cognitive sequelae of cardiac arrest. Neurology 63(10):1774-1778, 2004.
5. Chalkias A, Xanthos T: Post-cardiac arrest brain injury: pathophysiology and treatment. J Neurol Sci 315(1-2):1-8, 2012.
6. van der Lely AJ, Tschop M, Heiman ML, Ghigo E: Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25(3): 426-457, 2004.
7. Frago LM, Baquedano E, Argente J, Chowen JA: Neuroprotective actions of ghrelin and growth hormone secretagogues. Front Mol Neurosci 4:23, 2011.
8. Lopez NE, Gaston L, Lopez KR, Coimbra RC, Hageny A, Putnam J, Eliceiri B, Coimbra R, Bansal V: Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a UCP-2 mechanism. Brain Res 1489:140-148, 2012.
9. Qi L, Cui X, Dong W, Barrera R, Coppa GF, Wang P, Wu R: Ghrelin protects rats against traumatic brain injury and hemorrhagic shock through upregulation of UCP2. Ann Surg 260(1):169-178, 2014.
10. Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z: Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453(1):58-61, 2009.
11. Miao Y, Xia Q, Hou Z, Zheng Y, Pan H, Zhu S: Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochem Biophys Res Commun 359(3):795-800, 2007.
12. Cheyuo C, Wu R, Zhou M, Jacob A, Coppa G, Wang P: Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve. Shock 35(3):258-265, 2011.
13. Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park S: Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148(1):148-159, 2007.
14. Liu Y, Chen L, Xu X, Vicaut E, Sercombe R: Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol 9:17, 2009.
15. Lin JY, Liao XX, Li H, Wei HY, Liu R, Hu CL, Huang GQ, Dai G, Li X: Model of cardiac arrest in rats by transcutaneous electrical epicardium stimulation. Resuscitation 81(9):1197-1204, 2010.
16. Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, et al.: Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotox Res 15(4):332-347, 2009.
17. Lee J, Lim E, Kim Y, Li E, Park S: Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol 205(3):262-269, 2010.
18. Hwang S, Moon M, Kim S, Hwang L, Ahn KJ, Park S: Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Endocr J 56(4):609-617, 2009.
19. Banks WA, Tschop M, Robinson SM, Heiman ML: Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302(2):822-827, 2002.
20. Albertsmeier M, Teschendorf P, Popp E, Galmbacher R, Vogel P, Bottiger BW: Evaluation of a tape removal test to assess neurological deficit after cardiac arrest in rats. Resuscitation 74(3):552-558, 2007.
21. Papadimitriou D, Xanthos T, Dontas I, Lelovas P, Perrea D: The use of mice and rats as animal models for cardiopulmonary resuscitation research. Laboratory Animals 42(3):265-276, 2008.
22. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762): 656-660, 1999.
23. Chung H, Seo S, Moon M, Park S: Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198(3):511-521, 2008.
24. Pan W, Tu H, Kastin AJ: Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 27(4):911-916, 2006.
25. Yuan J, Yankner BA: Apoptosis in the nervous system. Nature 407(6805): 802-809, 2000.
26. Asnaghi L, Calastretti A, Bevilacqua A, D'Agnano I, Gatti G, Canti G, Delia D, Capaccioli S, Nicolin A: Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene 23(34):5781-5791, 2004.
27. Fleury C, Mignotte B, Vayssiere JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84(2-3):131-141, 2002.
28. Ersahin M, Toklu HZ, Erzik C, Cetinel S, Akakin D, Velioglu-Ogunc A, Tetik S, Ozdemir ZN, Sener G, Yegen BC: The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats. J Neurotrauma 27(6):1143-1155, 2010.
29. Donadelli M, Dando I, Fiorini C, Palmieri M: UCP2, a mitochondrial protein regulated at multiple levels. Cell Mol Life Sci 71(7):1171-1190, 2014.
30. Mehta SL, Li PA: Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke. J Cereb Blood Flow Metab 29(6):1069-1078, 2009.
31. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi SL, Warden CH, Castilho RF, Melcher T, Gonzalez-Zulueta M, et al.: Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med 9(8):1062-1068, 2003.
32. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG: Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3(5):379-386, 2006.
33. Barazzoni R, Bosutti A, Stebel M, Cattin MR, Roder E, Visintin L, Cattin L, Biolo G, Zanetti M, Guarnieri G: Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol Endocrinol Metab 288(1):E228-E235, 2005.
34. Tsubone T, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H: Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice. Regulatory Peptides 130(1-2):97-103, 2005.
35. Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, et al.: Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci 29(45):14057-14065, 2009.