-
1
-
-
67651089847
-
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): A proof-of-principle clinical trial with ribavirin
-
Assouline S, Culjkovic B, Cocolakis E et al. (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood 114:257-60
-
(2009)
Blood
, vol.114
, pp. 257-260
-
-
Assouline, S.1
Culjkovic, B.2
Cocolakis, E.3
-
2
-
-
77957737145
-
Ribavirin as an anti-cancer therapy: Acute myeloid leukemia and beyond?
-
Borden KL, Culjkovic-Kraljacic B (2010) Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leuk Lymphoma 51:1805-15
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 1805-1815
-
-
Borden, K.L.1
Culjkovic-Kraljacic, B.2
-
3
-
-
84867893435
-
Role of Tip60 in human melanoma cell migration, metastasis, and patient survival
-
Chen G, Cheng Y, Tang Y et al. (2012) Role of Tip60 in human melanoma cell migration, metastasis, and patient survival. J Invest Dermatol 132:2632-41
-
(2012)
J Invest Dermatol
, vol.132
, pp. 2632-2641
-
-
Chen, G.1
Cheng, Y.2
Tang, Y.3
-
4
-
-
14944352371
-
Prognostic significance of activated Akt expression in melanoma: A clinicopathologic study of 292 cases
-
Dai DL, Martinka M, Li G (2005) Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol 23:1473-82
-
(2005)
J Clin Oncol
, vol.23
, pp. 1473-1482
-
-
Dai, D.L.1
Martinka, M.2
Li, G.3
-
5
-
-
2342489456
-
EIF-4E expression and its role in malignancies and metastases
-
De Benedetti A, Graff JR (2004) eIF-4E expression and its role in malignancies and metastases. Oncogene 23:3189-99
-
(2004)
Oncogene
, vol.23
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
6
-
-
0033044355
-
EIF4E expression in tumors: Its possible role in progression of malignancies
-
De Benedetti A, Harris AL (1999) eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol 31:59-72
-
(1999)
Int J Biochem Cell Biol
, vol.31
, pp. 59-72
-
-
De Benedetti, A.1
Harris, A.L.2
-
7
-
-
0025107684
-
Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology
-
De Benedetti A, Rhoads RE (1990) Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. Proc Natl Acad Sci USA 87:8212-6
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 8212-8216
-
-
De Benedetti, A.1
Rhoads, R.E.2
-
8
-
-
0037115394
-
Constitutive activation of Akt/ protein kinase B in melanoma leads to up-regulation of nuclear factorkappaB and tumor progression
-
Dhawan P, Singh AB, Ellis DL et al. (2002) Constitutive activation of Akt/ protein kinase B in melanoma leads to up-regulation of nuclear factorkappaB and tumor progression. Cancer Res 62:7335-42
-
(2002)
Cancer Res
, vol.62
, pp. 7335-7342
-
-
Dhawan, P.1
Singh, A.B.2
Ellis, D.L.3
-
9
-
-
0038049137
-
Tumour-cell invasion and migration: Diversity and escape mechanisms
-
Friedl P, Wolf K (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3:362-74
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
10
-
-
65749084524
-
Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation
-
Ghosh B, Benyumov AO, Ghosh P et al. (2009) Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. ACS Chem Biol 4:367-77
-
(2009)
ACS Chem Biol
, vol.4
, pp. 367-377
-
-
Ghosh, B.1
Benyumov, A.O.2
Ghosh, P.3
-
11
-
-
0028897627
-
Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts
-
Graff JR, Boghaert ER, De Benedetti A et al. (1995) Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts. Int J Cancer 60:255-63
-
(1995)
Int J Cancer
, vol.60
, pp. 255-263
-
-
Graff, J.R.1
Boghaert, E.R.2
De Benedetti, A.3
-
12
-
-
65949111747
-
EIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival
-
Graff JR, Konicek BW, Lynch RL et al. (2009) eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res 69:3866-73
-
(2009)
Cancer Res
, vol.69
, pp. 3866-3873
-
-
Graff, J.R.1
Konicek, B.W.2
Lynch, R.L.3
-
13
-
-
34848901974
-
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
-
Graff JR, Konicek BW, Vincent TM et al. (2007) Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest 117:2638-48
-
(2007)
J Clin Invest
, vol.117
, pp. 2638-2648
-
-
Graff, J.R.1
Konicek, B.W.2
Vincent, T.M.3
-
15
-
-
84885603217
-
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-kappaB and is aberrantly regulated in acute myeloid leukemia
-
Hariri F, Arguello M, Volpon L et al. (2013) The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-kappaB and is aberrantly regulated in acute myeloid leukemia. Leukemia 27: 2047-55
-
(2013)
Leukemia
, vol.27
, pp. 2047-2055
-
-
Hariri, F.1
Arguello, M.2
Volpon, L.3
-
16
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
Hsieh AC, Liu Y, Edlind MP et al. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485:55-61
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
-
17
-
-
74849127935
-
Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells
-
Hung WC, Tseng WL, Shiea J et al. (2010) Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells. Cancer Lett 288:156-61
-
(2010)
Cancer Lett
, vol.288
, pp. 156-161
-
-
Hung, W.C.1
Tseng, W.L.2
Shiea, J.3
-
18
-
-
0034696293
-
Dual regulation of proliferation and apoptosis: C-myc in bitransgenic murine mammary tumor models
-
Jamerson MH, Johnson MD, Dickson RB (2000) Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models. Oncogene 19:1065-71
-
(2000)
Oncogene
, vol.19
, pp. 1065-1071
-
-
Jamerson, M.H.1
Johnson, M.D.2
Dickson, R.B.3
-
19
-
-
0033981730
-
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase
-
Johansson N, Ala-aho R, Uitto V et al. (2000) Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J Cell Sci 113:227-35
-
(2000)
J Cell Sci
, vol.113
, pp. 227-235
-
-
Johansson, N.1
Ala-Aho, R.2
Uitto, V.3
-
20
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108:153-64
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
21
-
-
11144220618
-
Ribavirin suppresses eIF4Emediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap
-
Kentsis A, Topisirovic I, Culjkovic B et al. (2004) Ribavirin suppresses eIF4Emediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci USA 101:18105-10
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 18105-18110
-
-
Kentsis, A.1
Topisirovic, I.2
Culjkovic, B.3
-
22
-
-
84892904953
-
Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion
-
Khosravi S, Wong RP, Ardekani GS et al. (2014) Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion. Br J Cancer 110:399-408
-
(2014)
Br J Cancer
, vol.110
, pp. 399-408
-
-
Khosravi, S.1
Wong, R.P.2
Ardekani, G.S.3
-
23
-
-
0025314596
-
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
-
Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345:544-7
-
(1990)
Nature
, vol.345
, pp. 544-547
-
-
Lazaris-Karatzas, A.1
Montine, K.S.2
Sonenberg, N.3
-
24
-
-
49349105425
-
Role of ING4 in human melanoma cell migration, invasion and patient survival
-
Li J, Martinka M, Li G (2008) Role of ING4 in human melanoma cell migration, invasion and patient survival. Carcinogenesis 29:1373-9
-
(2008)
Carcinogenesis
, vol.29
, pp. 1373-1379
-
-
Li, J.1
Martinka, M.2
Li, G.3
-
25
-
-
84863229979
-
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer
-
Li Y, Fan S, Koo J et al. (2012) Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer Biol Ther 13:272-80
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 272-280
-
-
Li, Y.1
Fan, S.2
Koo, J.3
-
26
-
-
70350231924
-
Loss of SNF5 expression correlates with poor patient survival in melanoma
-
Lin H, Wong RP, Martinka M et al. (2009) Loss of SNF5 expression correlates with poor patient survival in melanoma. Clin Cancer Res 15:6404-11
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6404-6411
-
-
Lin, H.1
Wong, R.P.2
Martinka, M.3
-
27
-
-
84889039757
-
JWA inhibits melanoma angiogenesis by suppressing ILK signaling and is an independent prognostic biomarker for melanoma
-
Lu J, Tang Y, Farshidpour M et al. (2013) JWA inhibits melanoma angiogenesis by suppressing ILK signaling and is an independent prognostic biomarker for melanoma. Carcinogenesis 34:2778-88
-
(2013)
Carcinogenesis
, vol.34
, pp. 2778-2788
-
-
Lu, J.1
Tang, Y.2
Farshidpour, M.3
-
29
-
-
2642566088
-
Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
-
Minotti G, Menna P, Salvatorelli E et al. (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229
-
(2004)
Pharmacol Rev
, vol.56
, pp. 185-229
-
-
Minotti, G.1
Menna, P.2
Salvatorelli, E.3
-
30
-
-
84900821965
-
Protein expression of eIF4E and integrin alphavbeta6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction
-
Niu Z, Wang J, Muhammad S et al. (2014) Protein expression of eIF4E and integrin alphavbeta6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction. Cell Biosci 4:23
-
(2014)
Cell Biosci
, vol.4
, pp. 23
-
-
Niu, Z.1
Wang, J.2
Muhammad, S.3
-
31
-
-
84857999385
-
Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis
-
Nogueira V, Sundararajan D, Kwan JM et al. (2012) Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. EMBO J 31:1134-46
-
(2012)
EMBO J
, vol.31
, pp. 1134-1146
-
-
Nogueira, V.1
Sundararajan, D.2
Kwan, J.M.3
-
32
-
-
25144470125
-
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin
-
Oridate N, Kim HJ, Xu X et al. (2005) Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin. Cancer Biol Ther 4:318-23
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 318-323
-
-
Oridate, N.1
Kim, H.J.2
Xu, X.3
-
33
-
-
0034637435
-
Translational control of the antiapoptotic function of Ras
-
Polunovsky VA, Gingras AC, Sonenberg N et al. (2000) Translational control of the antiapoptotic function of Ras. J Biol Chem 275:24776-80
-
(2000)
J Biol Chem
, vol.275
, pp. 24776-24780
-
-
Polunovsky, V.A.1
Gingras, A.C.2
Sonenberg, N.3
-
34
-
-
0029827631
-
Translational control of programmed cell death: Eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc
-
Polunovsky VA, Rosenwald IB, Tan AT et al. (1996) Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc. Mol Cell Biol 16:6573-81
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6573-6581
-
-
Polunovsky, V.A.1
Rosenwald, I.B.2
Tan, A.T.3
-
35
-
-
84869987776
-
MMP2 expression is a prognostic marker for primary melanoma patients
-
Rotte A, Martinka M, Li G (2012) MMP2 expression is a prognostic marker for primary melanoma patients. Cell Oncol (Dordr) 35:207-16
-
(2012)
Cell Oncol (Dordr)
, vol.35
, pp. 207-216
-
-
Rotte, A.1
Martinka, M.2
Li, G.3
-
36
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D, Montanaro L, Ma L et al. (2004) The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10:484-6
-
(2004)
Nat Med
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
-
37
-
-
0028291737
-
A matrix metalloproteinase expressed on the surface of invasive tumour cells
-
Sato H, Takino T, Okada Y et al. (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370:61-5
-
(1994)
Nature
, vol.370
, pp. 61-65
-
-
Sato, H.1
Takino, T.2
Okada, Y.3
-
38
-
-
77951757643
-
Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells
-
Shankar J, Messenberg A, Chan J et al. (2010) Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. Cancer Res 70:3780-90
-
(2010)
Cancer Res
, vol.70
, pp. 3780-3790
-
-
Shankar, J.1
Messenberg, A.2
Chan, J.3
-
39
-
-
0032520916
-
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92, 000 type IV collagenase secretion and in vitro invasion
-
Simon C, Goepfert H, Boyd D (1998) Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92, 000 type IV collagenase secretion and in vitro invasion. Cancer Res 58:1135-9
-
(1998)
Cancer Res
, vol.58
, pp. 1135-1139
-
-
Simon, C.1
Goepfert, H.2
Boyd, D.3
-
40
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X et al. (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65:7052-8
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
-
41
-
-
33645092920
-
Cutaneous melanoma: Available therapy for metastatic disease
-
Tarhini AA, Agarwala SS (2006) Cutaneous melanoma: available therapy for metastatic disease. Dermatol Ther 19:19-25
-
(2006)
Dermatol Ther
, vol.19
, pp. 19-25
-
-
Tarhini, A.A.1
Agarwala, S.S.2
-
42
-
-
0029831503
-
Matrix metalloproteinase- 2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value
-
Vaisanen A, Tuominen H, Kallioinen M et al. (1996) Matrix metalloproteinase- 2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value. J Pathol 180:283-9
-
(1996)
J Pathol
, vol.180
, pp. 283-289
-
-
Vaisanen, A.1
Tuominen, H.2
Kallioinen, M.3
-
43
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel HG, De Stanchina E, Fridman JS et al. (2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428:332-7
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
De Stanchina, E.2
Fridman, J.S.3
-
44
-
-
0345643514
-
Regulation of matrix metalloproteinase expression in tumor invasion
-
Westermarck J, Kahari VM (1999) Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13:781-92
-
(1999)
FASEB J
, vol.13
, pp. 781-792
-
-
Westermarck, J.1
Kahari, V.M.2
-
45
-
-
84871570209
-
EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma
-
Wu M, Liu Y, Di X et al. (2013) EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma. Med Oncol 30:400
-
(2013)
Med Oncol
, vol.30
, pp. 400
-
-
Wu, M.1
Liu Di Y, X.2
-
46
-
-
33947716942
-
Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray
-
Yang SX, Hewitt SM, Steinberg SM et al. (2007) Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray. Oncol Rep 17:281-7
-
(2007)
Oncol Rep
, vol.17
, pp. 281-287
-
-
Yang, S.X.1
Hewitt, S.M.2
Steinberg, S.M.3
-
47
-
-
81855224569
-
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
-
Yellen P, Saqcena M, Salloum D et al. (2011) High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle 10:3948-56
-
(2011)
Cell Cycle
, vol.10
, pp. 3948-3956
-
-
Yellen, P.1
Saqcena, M.2
Salloum, D.3
-
48
-
-
79958800970
-
Prognostic significance of RUNX3 expression in human melanoma
-
Zhang Z, Chen G, Cheng Y et al. (2011) Prognostic significance of RUNX3 expression in human melanoma. Cancer 117:2719-27
-
(2011)
Cancer
, vol.117
, pp. 2719-2727
-
-
Zhang, Z.1
Chen, G.2
Cheng, Y.3
-
49
-
-
84875966967
-
Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma
-
Zhu YH, Fu L, Chen L et al. (2013) Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Res 73:2298-309
-
(2013)
Cancer Res
, vol.73
, pp. 2298-2309
-
-
Zhu, Y.H.1
Fu, L.2
Chen, L.3
|