Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion

British Journal of Cancer

Volumn 110, Issue 2, 2014, Pages 399-408

  Khosravi, S ^a   Wong, R P C ^a   Ardekani, G S ^a   Zhang, G ^a   Martinka, M ^a   Ong, C J ^a   Li, G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Akt; EIF5A2; invasion; melanoma; patient survival; prognostic marker

Indexed keywords

EUKARYOTIC TRANSLATION INITIATION FACTOR 5A2; GELATINASE A; INITIATION FACTOR; PROTEIN KINASE B; UNCLASSIFIED DRUG; INITIATION FACTOR 5A; INITIATION FACTOR 5A2; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR MARKER;

ADULT; ARTICLE; CANCER GROWTH; CELL INVASION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DYSPLASTIC NEVUS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MELANOMA CELL; METASTATIC MELANOMA; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL; TISSUE MICROARRAY; TUMOR INVASION; ZYMOGRAPHY; CANCER PROGNOSIS; CELL INVASION ASSAY; CORRELATION ANALYSIS; DISEASE SPECIFIC SURVIVAL; FLUORESCENCE ACTIVATED CELL SORTING; MELANOMA; MELANOMA CELL LINE; OVERALL SURVIVAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SKIN CARCINOGENESIS; THICKNESS;

APOPTOSIS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DISEASE PROGRESSION; HUMANS; MATRIX METALLOPROTEINASE 2; MELANOMA; NEOPLASM INVASIVENESS; PEPTIDE INITIATION FACTORS; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; RNA-BINDING PROTEINS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84892904953     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.688     Document Type: Article

References (38)

1. American Cancer Society ACS (2011) Cancer Facts & Figures 2011. American Cancer Society: Atlanta, GA, USA.
2. Chen B, Tardell C, Higgins B, Packman K, Boylan JF, Niu H (2012a) BRAFV600E negatively regulates the AKT pathway in melanoma cell lines. PLoS One 7: e42598.
3. Chen G, Cheng Y, Tang Y, Martinka M, Li G (2012b) Role of Tip60 in human melanoma cell migration, metastasis, and patient survival. J Invest Dermatol 132: 2632-2641.
4. Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D (2009) Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Cancer Epidemiol Biomarkers Prev 18: 400-408.
5. Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J (2012) p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res 72: 5966-5975.
6. Clement PM, Henderson CA, Jenkins ZA, Smit-McBride Z, Wolff EC, Hershey JW, Park MH, Johansson HE (2003) Identification and characterization of eukaryotic initiation factor 5A-2. Eur J Biochem 270: 4254-4263.
7. Cummins DL, Cummins JM, Pantle H, Silverman MA, Leonard AL, Chanmugam A (2006) Cutaneous malignant melanoma. Mayo Clin Proc 81: 500-507.
8. Dai DL,Makretsov N, Campos EI,Huang C, Zhou Y, Huntsman D, Martinka M, Li G (2003) Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 9: 4409-4414.
9. Dai DL, Martinka M, Li G (2005) Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol 23: 1473-1482.
10. Dhawan P, Singh AB, Ellis DL, Richmond A (2002) Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res 62: 7335-7342.
11. Friedl P, Wolf K (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362-374.
12. Gray-Schopfer V, Wellbrock C, Marais R (2007) Melanoma biology and new targeted therapy. Nature 445: 851-857.
13. Guan XY, Fung JM, Ma NF, Lau SH, Tai LS, Xie D, Zhang Y, Hu L, Wu QL, Fang Y, Sham JS (2004) Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Res 64: 4197-4200.
14. Hao H, Muniz-Medina VM, Mehta H, Thomas NE, Khazak V, Der CJ, Shields JM (2007) Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol Cancer Ther 6: 2220-2229.
15. He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D (2011) Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients. Int J Cancer 129: 143-150.
16. Hung WC, Tseng WL, Shiea J, Chang HC (2010) Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells. Cancer Lett 288: 156-161.
17. Jafarnejad SM, Ardekani GS, Ghaffari M, Martinka M, Li G (2012) Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion. Oncogene 239: 1-9.
18. Jasiulionis MG, Luchessi AD, Moreira AG, Souza PP, Suenaga AP, Correa M, Costa CA, Curi R, Costa-Neto CM (2007) Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth. Cell Biochem Funct 25: 109-114.
19. Karjalainen JM, Kellokoski JK, Eskelinen MJ, Alhava EM, Kosma VM (1998) Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma. J Clin Oncol 16: 3584-3591.
20. Li J, Martinka M, Li G (2008) Role of ING4 in human melanoma cell migration, invasion and patient survival. Carcinogenesis 29: 1373-1379.
21. Marchet A, Mocellin S, Belluco C, Ambrosi A, DeMarchi F, Mammano E, Digito M, Leon A, D'Arrigo A, Lise M, Nitti D (2007) Gene expression profile of primary gastric cancer: towards the prediction of lymph node status. Ann Surg Oncol 14: 1058-1064.
22. Miller AJ, Mihm Jr. MC (2006) Melanoma. N Engl J Med 355: 51-65.
23. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S (2000) Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 97: 3207-3212.
24. Qin H, Sun Y, Benveniste EN (1999) The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. J Biol Chem 274: 29130-29137.
25. Ramaswamy S, Ross KN, Lander ES, Golub TR (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33: 49-54.
26. Rotte A, Martinka M, Li G (2012) MMP2 expression is a prognostic marker for primary melanoma patients. Cell Oncol (Dordr) 35: 207-216.
27. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370: 61-65.
28. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
29. Stahl JM, Cheung M, Sharma A, Trivedi NR, Shanmugam S, Robertson GP (2003) Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res 63: 2881-2890.
30. Sun XF, Zhang H (2007) NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol 22: 1387-1398.
31. Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Guan XY (2010) Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology 51: 1255-1263.
32. Tsao H, Mihm Jr. MC, Sheehan C (2003) PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. J Am Acad Dermatol 49: 865-872.
33. Vaisanen A, Tuominen H, Kallioinen M, Turpeenniemi-Hujanen T (1996) Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value. J Pathol 180: 283-289.
34. Wolff EC, Lee YB, Chung SI, Folk JE, Park MH (1995) Deoxyhypusine synthase from rat testis: purification and characterization. J Biol Chem 270: 8660-8666.
35. Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY (2008) Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. Hum Pathol 39: 80-86.
36. Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY (2009) Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. Gynecol Oncol 112: 314-318.
37. Zhang Z, Chen G, Cheng Y, Martinka M, Li G (2011) Prognostic significance of RUNX3 expression in human melanoma. Cancer 117: 2719-2727.
38. Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, Bian XW, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D (2011) Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. Gut 61: 562-575.