Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization

Nature Materials

Volumn 14, Issue 5, 2015, Pages 532-539

  Chiappini, C ^a   De Rosa, E ^b   Martinez, J O ^b   Liu, X ^b   Steele, J ^a   Stevens, M M ^a   Tasciotti, E ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFFICIENCY; MOLECULAR BIOLOGY; NUCLEIC ACIDS; SILICON; TOXICITY;

BLOOD PERFUSION; CELL INTERNALIZATION; COMPLEX EQUIPMENT; CONTROLLED DELIVERY; INTRACELLULAR DELIVERY; METAL-ASSISTED CHEMICAL ETCHING; NEO-VASCULARIZATION; SILICON NANONEEDLES;

NANONEEDLES;

NANOMATERIAL; SILICON; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DEVICES; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOUSE; NEEDLE; PHARMACOLOGY; PLASMID; PROCEDURES; SKELETAL MUSCLE; VASCULARIZATION;

ANIMALS; HUMANS; MICE; MUSCLE, SKELETAL; NANOSTRUCTURES; NEEDLES; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; SILICON; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84928401196     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat4249     Document Type: Article

References (46)

1. Leader, B., Baca, Q. J. & Golan, D. E. Protein therapeutics: A summary and pharmacological classification. Nature Rev. Drug Discov. 7, 21-39 (2008).
2. Vlieghe, P., Lisowski, V.,Martinez, J. & Khrestchatisky, M. Synthetic therapeutic peptides: Science and market. Drug Discov. Today 15, 40-56 (2010).
3. Kole, R., Krainer, A. R. & Altman, S. RNA therapeutics: Beyond RNA interference and antisense oligonucleotides. Nature Rev. Drug Discov. 11, 125-140 (2012).
4. Khademhosseini, A. Microscale technologies for tissue engineering and biology. Proc. Natl Acad. Sci. USA 103, 2480-2487 (2006).
5. Whitehead, K. A., Langer, R. & Anderson, D. G. Knocking down barriers: Advances in siRNA delivery. Nature Rev. Drug Discov. 8, 129-138 (2009).
6. Saltzman,W. M. & Luo, D. Synthetic DNA delivery systems. Nature Biotechnol. 18, 33-37 (2000).
7. Thomas, C. E., Ehrhardt, A. & Kay, M. A. Progress and problems with the use of viral vectors for gene therapy. Nature Rev. Genet. 4, 346-358 (2003).
8. Mingozzi, F. & High, K. A. Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges. Nature Rev. Genet. 12, 341-355 (2011).
9. Lefesvre, P., Attema, J. & van Bekkum, D. A comparison of e-cacy and toxicity between electroporation and adenoviral gene transfer. BMC Mol. Biol. 3, 12 (2002).
10. Aihara, H. & Miyazaki, J-I. Gene transfer into muscle by electroporation in vivo. Nature Biotechnol. 16, 867-870 (1998).
11. Nishikawa, M. & Huang, L. Nonviral vectors in the new millennium: Delivery barriers in gene transfer. Hum. Gene Ther. 12, 861-870 (2001).
12. Shalek, A. K. et al. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc. Natl Acad. Sci. USA 107, 1870-1875 (2010).
13. Robinson, J. T. et al. Vertic al nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits. Nature Nanotech. 7, 180-184 (2012).
14. Yan, R. et al. Nanowire-based single-cell endoscopy. Nature Nanotech. 7, 191-196 (2011).
15. Han, S.W. et al. High-e-ciency DNA injection into a single human mesench ymal stem cell using a nanoneedle and atomic force microscopy. Nanomedicine: Nanotechnol. Biol. Med. 4, 215-225 (2008).
16. Shalek, A. K. et al. Nanowire-mediated delivery enables functional interrogation of primary immune cells: Application to the analysis of chronic lymphocytic leukemia. Nano Lett. 12, 6498-6504 (2012).
17. Xu A. M.,et al. Quantification of nanowire penetration into living cells Nature Commun. 5, 3613, 2014).
18. Sharei, A. et al. A vector-free microfluidic platform for intracellular delivery. Proc. Natl Acad. Sci. USA 110, 2082-2087 (2013).
19. Hanson, L., Lin, Z. C., Xie, C., Cui, Y. & Cui, B. Characterization of the cell-nanopillar interface by transmission electron microscopy. Nano Lett. 12, 5815-5820 (2012).
20. Xie, X. et al.Mechanical model of vertical nanowire cell penetration. Nano Lett. 13, 6002-6008 (2013).
21. Xie, C., Lin, Z., Hanson, L., C ui, Y. & Cui, B. Intracellular recording of action potentials by nanopillar electroporation. Nature Nanotech. 7, 185-190 (2012).
22. Wang, Y. et al. Poking cells for e-cient vector-free intracellular delivery. Nature Commun. 5, 4466 (2014).
23. Anderson, S. H. C., Elliott, H.,Wallis, D. J., Canham, L. T. & Powell, J. J. Dissolution of di-erent forms of part ially porous silicon wafers under simulated physiological conditions. Phys. Status Solidi A 197, 331-335 (2003).
24. Canham, L. T. Bioactive silicon structure fabrication through nanoetching techniques. Adv. Mater. 7, 1033-1037 (1995).
25. Chiappini, C. et al. Tailored porous silicon microparticles: Fabrication and properties. ChemPhysChem 11, 1029-1035 (2010).
26. Tasciotti, E. et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nature Nanotech. 3, 151-157 (2008).
27. Tanak a, T. et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 70, 3687-3696 (2010).
28. Par k, J-H. et al. Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nature Mater. 8, 331-336 (2009).
29. Goh, A. S-W. et al. A novel approach to brachytherapy in hepatocellular carcinoma using a phosphorous32 (32P) brachytherapy delivery device-A first-in-man study. Int. J. Radiat. Oncol. Biol. Phys. 67, 786-792 (2007).
30. Anglin, E., Cheng, L., Freeman,W. & Sailor, M. Porous silicon in drug delivery devices and materials. Adv. Drug Deliv. Rev. 60, 1266-1277 (2008).
31. Chiappini, C., Liu, X., Fakhoury, J. R. & Ferrari, M. Biodegradable porous silicon barcode nanowires with defined geometry. Adv. Funct. Mater. 20, 2231-2239 (2010).
32. Obataya, I., Nakamura, C., Han, S., Nakamura, N. & Miyake, J. Mechan ical sensing of the penetration of various nanoneedles into a living cell using atomic force microscopy. Biosens. Bioelectron. 20, 1652-1655 (2005).
33. Na, Y-R. et al. Probing enzymatic activity inside living cells using a nanowire-cell 'sandwich' assay. Nano Lett. 13, 153-158 (2013).
34. Muralidharan-Chari, V., Clancy, J.W., Sedgwick, A. & D'Souza-Schorey, C. Microvesicles: Mediators of extracellular communication during cancer progression. J. Cell Sci. 123, 1603-1611 (2010).
35. Ratajczak, J. et al. Embryonic stem cell-derived microvesicles reprogram hematop oietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20, 847-856 (2006).
36. Yuan, A. et al. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS ONE 4, e4722 (2009).
37. Shen, Z. et al. Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry. Anal. Chem. 73, 612-619 (2000).
38. Lee, J.W., Park, J-H. & Prausnitz, M. R. Dissolving microneedles for transdermal drug delivery. Biomaterials 29, 2113-2124 (2008).
39. Gross S.,et al. Bioluminescence imaging of myeloperoxidase activity in vivo Nature Med. 15 455-461 2009).
40. Luxembourg, A., Evans, C. F. & Hannaman, D. Electroporation-based DNA immunisation: Translation to the clinic. Expert Opin. Biol. Ther. 7, 1647-1664 (2007).
41. Yancopoulos, G. D. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248 (2000).
42. Tammela, T., Enholm, B., Alitalo, K. & Paavonen, K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 65, 550-563 (2005).
43. De Muth, P. C. et al. Polymer multilayer tattooing for enhanced DNA vaccination. Nature Mater. 12, 367-376 (2013).
44. Kim, Y-C., Park, J-H. & Prausnitz, M. R. Microneedles for drug and vaccine delivery. Adv. Drug Deliv. Rev. 64, 1547-1568 (2012).
45. Gershonowitz, A. & Gat, A. VoluDerm Microneedle Technology for Skin Treatments-In Vivo Histological Evidence. J. Cosmetic Laser Surg. 17, 9-14 (2015).
46. Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H. & Tomic-Canic, M. Growth factors and cytokines in wound healing.Wound Repair Regen. 16, 585-601 (2008).