Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication

Toxicon

Volumn 116, Issue , 2016, Pages 23-28

  Schnell, Leonie ^a   Dmochewitz Kück, Lydia ^a   Feigl, Peter ^a   Montecucco, Cesare ^b   Barth, Holger ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Auranofin; Cellular uptake; Diphtheria toxin; Endosome; Membrane translocation; Thioredoxin reductase

Indexed keywords

AURANOFIN; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN A; DISULFIDE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; PROTECTIVE AGENT;

ARTICLE; CELL MEMBRANE; CELL PH; CELL PROTECTION; CELL STRUCTURE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DIPHTHERIA; DRUG INHIBITION; ENDOCYTOSIS; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HELA CELL LINE; HUMAN; METABOLISM; PH; TRANSPORT AT THE CELLULAR LEVEL;

AURANOFIN; BIOLOGICAL TRANSPORT; CYTOSOL; DIPHTHERIA TOXIN; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; PROTECTIVE AGENTS; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84928389594     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2015.04.012     Document Type: Article

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