Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration

Cellular and Molecular Life Sciences

Volumn 72, Issue 11, 2015, Pages 2199-2222

  Melis, V ^a   Zabke, C ^b   Stamer, K ^b   Magbagbeolu, M ^b   Schwab, K ^b   Marschall, P ^b   Veh, R W ^b   Bachmann, S ^b   Deiana, S ^a   Moreau, P H ^a   Davidson, K ^a   Harrington, K A ^a   Rickard, J E ^a   Horsley, D ^a   Garman, R ^c   Mazurkiewicz, M ^d   Niewiadomska, G ^d   Wischik, C M ^a   Harrington, C R ^a   Riedel, G ^a   Theuring, F ^b   more..

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Institute of Anatomy ^*  (United States)

^d NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Motor impairment; P301L; Spatial cognition; Tau protein; Transgenic mice; Truncated cDNA Tau296 390

Indexed keywords

MAPT PROTEIN, HUMAN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL; BIOSYNTHESIS; COGNITION; COGNITIVE DEFECT; DISEASE MODEL; FEMALE; FRONTOTEMPORAL DEMENTIA; GENETICS; HIPPOCAMPUS; HUMAN; MALE; MOUSE; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; PROTEIN TERTIARY STRUCTURE; PROTEINOSIS; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STRUCTURE, TERTIARY; TAU PROTEINS;

EID: 84928386659     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1804-z     Document Type: Article

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