Clinical features of repetitive traumatic brain injury and chronic traumatic encephalopathy

Brain Pathology

Volumn 25, Issue 3, 2015, Pages 304-317

  Montenigro, Philip H ^a   Bernick, Charles ^a   Cantu, Robert C ^a,b,c,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMERSON HOSPITAL   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Sports Legacy Institute   (United States)

Author keywords

Boxing; Chronic traumatic encephalopathy; Concussion; Football; Mild traumatic brain injury; Neuropathology

Indexed keywords

ACUTE DISEASE; ATHLETIC REHABILITATION; AUTOPSY; BIOMECHANICS; BOXING; BRAIN CONCUSSION; CASE STUDY; CHRONIC DISEASE; CHRONIC TRAUMATIC ENCEPHALOPATHY; CLINICAL FEATURE; CONFERENCE PAPER; DEGENERATIVE DISEASE; FOOTBALL; HUMAN; MOTOR NEURON DISEASE; NEUROPATHOLOGY; PHARMACEUTICAL CARE; POSTCONCUSSION SYNDROME; RISK FACTOR; SECOND IMPACT SYNDROME; SPORT INJURY; TRAUMATIC BRAIN INJURY; BRAIN INJURIES; CASE REPORT; COMPLICATION; DISEASE COURSE; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES;

ATHLETIC INJURIES; BIOMECHANICAL PHENOMENA; BRAIN INJURIES; CHRONIC DISEASE; DISEASE PROGRESSION; HUMANS; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; RISK FACTORS;

EID: 84928333483     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12250     Document Type: Conference Paper

References (97)

1. Amen DG, Wu JC, Taylor D, Willeumier K, (2011) Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. J Psychoactive Drugs 43: 1-5.
2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders. DSM-IV, Washington, DC.
3. Baugh CM, Kiernan PT, Kroshus E, Daneshvar DH, Montenigro PH, McKee AC, Stern R, (2014) Frequency of head impact related outcomes by position in NCAA Division I collegiate football players. J Neurotrauma 32 (5): 314-326.
4. Baugh CM, Robbins CA, Stern RA, McKee AC, (2014) Current understanding of chronic traumatic encephalopathy. Curr Treat Options Neurol 16: 1-13.
5. Bernick C, Banks S, (2013) What boxing tells us about repetitive head trauma and the brain. Alzheimers Res Ther 5: 1-6.
6. Bernick C, Banks S, Phillips M, Lowe M, Shin W, Obuchowski N, et‰al (2013) Professional fighters brain health study: rationale and methods. Am J Epidemiol 178: 280-286.
7. Betti O, Ottino C, (1969) Pugilistic encephalopathy. Acta Neurol Latinoam 15: 47-51.
8. Blennow K, Hardy J, Zetterberg H, (2012) The neuropathology and neurobiology of traumatic brain injury. Neuron 76: 886-899.
9. Boden BP, Tacchetti RL, Cantu RC, Knowles SB, Mueller FO, (2007) Catastrophic head injuries in high school and college football players. Am J Sports Med 35: 1075-1081.
10. Brandenburg W, Hallervorden J, (1954) Dementia pugilistica mit anatomischem Befund. Virchows Arch 325: 680-709.
11. Brown LM, Schinka JA, (2005) Development and initial validation of a 15-item informant version of the Geriatric Depression Scale. Int J Geriatr Psychiatry 20: 911-918.
12. Cantu R, (1986) Guidelines for return to contact sports after a cerebral concussion. Physician Sportsmed 14: 75.
13. Cantu R, Hyman M, (2012) Concussions and Our Kids. Houghton Mifflin: New York, New York.
14. Cantu RC, (2000) Biomechanics of head injury. In: Neurologic Athletic Head and Spine Injuries., RC Cantu, (ed.), pp. 2-5. WB Saunders Company: Philadelphia.
15. Cantu RC, (2006) An overview of concussion consensus statements since 2000. Neurosurg Focus 21: 1-6.
16. Cantu RC, (2013) Role of diffusion tensor imaging MRI in detecting brain injury in asymptomatic contact athletes. World Neurosurg 80: 792-793.
17. Cantu RC, (2013) The role of the neurologist in concussions: when to tell your patient to stop. JAMA Neurol 70: 1481-1482.
18. Cantu RC, Guskiewicz K, Register-Mihalik JK, (2010) A retrospective clinical analysis of moderate to severe athletic concussions. PM R 2: 1088-1093.
19. Casson IR, Sham R, Campbell EA, Tarlau M, Didomenico A, (1982) Neurological and CT evaluation of knocked-out boxers. J Neurol Neurosurg Psychiatr 45: 170-174.
20. Cava L, (1952) The injuries of boxing. Deutsch Sportéirzte Kongress 79: 817.
21. Constantinides J, Tissot R, (1967) [Generalized Alzheimer's neurofibrillary lesions without senile plaques. (Presentation of one anatomo-clinical case)]. Schweiz Arch Neurol Neurochir Psychiatr 100: 117-130.
22. Cordeiro Júnior Q, Oliveira AMD, (2001) Parkinsonian, cerebellar, psychotic and demential symptoms in ex-boxer: case report. Arq Neuropsiquiatr 59 (2A): 283-285.
23. Corrigan JD, Bogner J, (2007) Initial reliability and validity of the Ohio State University TBI identification method. J Head Trauma Rehabil 22: 318-329.
24. Corrigan JD, Bogner J, (2007) Screening and identification of TBI. J Head Trauma Rehabil 22: 315-317.
25. Corsellis J, Bruton C, Freeman-Browne D, (1973) The aftermath of boxing. Psychol Med 3: 270-303.
26. Critchley M, (1949) Punch-drunk syndromes: the chronic traumatic encephalopathy of boxers. In: Hommage a Clovis Vincent. pp. 131-141. Maloine: Paris.
27. Critchley M, (1957) Medical aspects of boxing, particularly from a neurological standpoint. Br Med J 1: 357-362.
28. Crook T, Ferris S, Bartus R, (1983) Assessment in geriatric Psychopharmacology. Mark Powley Associates: New Canaan, Conn.
29. Galvin J, Roe C, Powlishta K, Coats M, Muich S, Grant E, et‰al (2005) The AD8: a brief informant interview to detect dementia. Neurology 65: 559-564.
30. Gardner A, Iverson GL, McCrory P, (2014) Chronic traumatic encephalopathy in sport: a systematic review. Br J Sports Med 48: 84-90.
31. Giza C, Kutcher J, Ashwal S, (2013) Guideline Development Subcommittee of the American Academy of Neurology. Summary of evidence-based guideline update: evaluation and management of concussion in sports. Neurology 80: 2250-2257.
32. Giza CC, Griesbach GS, Hovda DA, (2005) Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain. Behav Brain Res 157: 11-22.
33. Grahmann H, Ule G, (1957) [Diagnosis of chronic cerebral symptoms in boxers (dementia pugilistica & traumatic encephalopathy of boxers).]. Psychiatr Neurol (Basel) 134: 261-283.
34. Grinnon ST, Miller K, Marler JR, Lu Y, Stout A, Odenkirchen J, Kunitz S, (2012) National institute of neurological disorders and stroke common data element project-approach and methods. Clin Trials 9: 322-329.
35. Handratta V, Hsu E, Vento J, Yang C, Tanev K, (2010) Neuroimaging findings and brain-behavioral correlates in a former boxer with chronic traumatic brain injury. Neurocase 16: 125-134.
36. Harvey P, Newsom Davis J, (1974) Traumatic encephalopathy in a young boxer. Lancet 304: 928-929.
37. Hazrati LN, Tartaglia MC, Diamandis P, Davis KD, Green RE, Wennberg R, et‰al (2013) Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology. Front Hum Neurosci 7: 1-9.
38. Jayarao M, Chin LS, Cantu RC, (2010) Boxing-related head injuries. Physician Sportsmed 38: 18-26.
39. Jedliński J, Gatarski J, Szymusik A, (1971) Encephalopathia pugilistica (punch drunkeness). Acta Med Pol 12: 443-451.
40. Jordan B, (1987) Neurologic aspects of boxing. Arch Neurol 44: 453-459.
41. Jordan BD, (1992) Neurologic injuries in boxing. In: Medical Aspects of Boxing., Barry Jordan, (ed.), pp. 150-152. CRC Press: Boca Raton, Florida.
42. Jordan BD, (1998) Dementia pugilistica. In: Neurobiology of Primary Dementia., Marshal F. Folstein MD, (ed.), pp. 191-203, American Psychiatric Press: Washington, DC.
43. Jordan BD, (2000) Chronic traumatic brain injury associated with boxing. Semin Neurol 20: 179-185.
44. Jordan BD, (2013) The clinical spectrum of sport-related traumatic brain injury. Nat Rev Neurol 9: 222-230.
45. Kerr ZY, Marshall SW, Guskiewicz KM, (2012) Reliability of concussion history in former professional football players. Med Sci Sports Exerc 44: 377-382.
46. Koerte IK, Kaufmann D, Hartl E, Bouix S, Pasternak O, Kubicki M, et‰al (2012) A prospective study of physician-observed concussion during a varsity university hockey season: white matter integrity in ice hockey players. Part 3 of 4. Neurosurg Focus 33: 1-7.
47. Lehman EJ, (2013) Epidemiology of neurodegeneration in American-style professional football players. Alzheimer Res Ther 5: 34-41.
48. Lehman EJ, Hein MJ, Baron SL, Gersic CM, (2012) Neurodegenerative causes of death among retired National Football League players. Neurology 79: 1970-1974.
49. Levin B, Bhardwaj A, (2014) Chronic traumatic encephalopathy: a critical appraisal. Neurocrit Care 20: 334-344.
50. Marchi N, Bazarian JJ, Puvenna V, Janigro M, Ghosh C, Zhong J, et‰al (2013) Consequences of repeated blood-brain barrier disruption in football players. PLoS ONE 8: e56805.
51. McCrory P, Meeuwisse WH, Kutcher JS, Jordan BD, Gardner A, (2013) What is the evidence for chronic concussion-related changes in retired athletes: behavioural, pathological and clinical outcomes? Br J Sports Med 47: 327-330.
52. McKee A, Stern R, Nowinski C, Stein T, Alvarez V, Daneshvar D, et‰al (2013) The spectrum of disease in chronic traumatic encephalopathy. Brain 136: 43-64.
53. McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, et‰al (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy following repetitive head injury. J Neuropathol Exp Neurol 68: 709-735.
54. McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, et‰al (2010) TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 69: 918-929.
55. McKee AC, Daneshvar DH, Alvarez VE, Stein TD, (2014) The neuropathology of sport. Acta Neuropathol 127: 29-51.
56. Mendez MF, (1995) The neuropsychiatric aspects of boxing. Int J Psychiatr Med 25: 249-262.
57. Meyers KR, Dorencamp DG, Suzuki K, (1974) Amyotrophic lateral sclerosis with diffuse neurofibrillary changes: report of a case. Arch Neurol 30: 84-89.
58. Mez J, Stern RA, McKee AC, (2013) Chronic traumatic encephalopathy: where are we and where are we going? Curr Neurol Neurosci Rep 13: 1-12.
59. Mitsis E, Riggio S, Kostakoglu L, Dickstein D, Machac J, Delman B, et‰al (2014) Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury. Transl Psychiatr 4: e441.
60. Montenigro P, Stern R, (2014) Author response clinical presentation of chronic traumatic encephalopathy. Neurology 83: 1992-1993.
61. Montenigro P, Baugh C, Daneshvar D, Mez J, Budson A, Au R, et‰al (2014) Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimers Res Ther 6: 1-17.
62. Montenigro P, Corp D, Stein T, Cantu R, Stern R, (2015) Chronic traumatic encephalopathy: historical origins and current perspective. Annu Rev Clin Psychol doi: 10.1146/annurev-clinpsy-032814-112814
63. Ng TS, Lin AP, Koerte IK, Pasternak O, Liao H, Merugumala S, et‰al (2014) Neuroimaging in repetitive brain trauma. Alzheimers Res Ther 6: 10-25.
64. Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH, (2005) Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 57: 128-134, discussion -34.
65. World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines http://www.who.int/classifications/icd/en/bluebook.pdf
66. Otero Siliceo E, Padilla Rubio J, (2004) Dementia pugilistica 1a. parte. Arch Neurocien (México, DF) 9: 114-119.
67. Pellman EJ, Viano DC, Tucker AM, Casson IR, Waeckerle JF, (2003) Concussion in professional football: reconstruction of game impacts and injuries. Neurosurgery 53: 799-814.
68. Petraglia AL, Maroon JC, Bailes JE, (2012) From the field of play to the field of combat: a review of the pharmacological management of concussion. Neurosurgery 70: 1520-1533.
69. Pfeffer R, Kurosaki T, Harrah C, Chance J, Filos S, (1982) Measurement of functional activities in older adults in the community. J Gerontol 37: 323-329.
70. Robbins CA, Daneshvar DH, Picano JD, Gavett BE, Baugh CM, Riley DO, et‰al (2014) Self-reported concussion history: impact of providing a definition of concussion. Open Access J Sports Med 5: 99-103.
71. Roberts A, (1969) Brain Damage in Boxers: A Study of the Prevalence of Traumatic Encephalopathy among ex-Professional Boxers. Pitman Medical & Scientific Publishing Co: London.
72. Ross RJ, Cole M, Thompson JS, Kim KH, (1983) Boxers-computed tomography, EEG, and neurological evaluation. JAMA 249: 211-213.
73. Sayed N, Culver C, Dams-O'Connor K, Hammond F, Diaz-Arrastia R, (2013) Clinical phenotype of dementia after traumatic brain injury. J Neurotrauma 30: 1117-1122.
74. Seichepine DR, Stamm JM, Daneshvar DH, Riley DO, Baugh CM, Gavett BE, et‰al (2013) Profile of self-reported problems with executive functioning in college and professional football players. J Neurotrauma 30: 1299-1304.
75. Shin W, Mahmoud S, Sakaie K, Banks S, Lowe M, Phillips M, et‰al (2014) Diffusion measures indicate fight exposure-related damage to cerebral white matter in boxers and mixed martial arts fighters. AJNR Am J Neuroradiol 35: 285-290.
76. Sim A, Terryberry-Spohr L, Wilson KR, (2008) Prolonged recovery of memory functioning after mild traumatic brain injury in adolescent athletes. J Neurosurg 108: 511-516.
77. Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, et‰al (2014) Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA 311: 1883-1888.
78. Sinnott RA, Maddela RL, Bae S, Best T, (2012) Dietary supplementation and the quality of life of retired football players. J Int Soc Sports Nutr 9 (Suppl. 1): P28.
79. Slobounov S, Bazarian J, Bigler E, Cantu R, Hallett M, Harbaugh R, et‰al (2013) Sports-related concussion: ongoing debate. Br J Sports Med 48: 75-76.
80. Small GW, Kepe V, Siddarth P, Ercoli LM, Merrill DA, Donoghue N, et‰al (2013) PET scanning of brain tau in retired national football league players: preliminary findings. Am J Geriatr Psychiatr 21: 138-144.
81. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et‰al (2011) Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7: 280-292.
82. Spitznagel MB, Tremont G, (2005) Cognitive reserve and anosognosia in questionable and mild dementia. Arch Clin Neuropsychol 20: 505-515.
83. Stamm JM, Bourlas AP, Baugh CM, Fritts NG, Daneshvar DH, Martin BM, et‰al (2015) Age of first exposure to football and later-life cognitive impairment in former NFL players. Neurology 84: 1-7.
84. Stein TD, Alvarez VE, McKee AC, (2014) Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimers Res Ther 6: 4-14.
85. Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC, (2011) Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. PM R 3: S460-S467.
86. Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, et‰al (2013) Clinical presentation of chronic traumatic encephalopathy. Neurology 81: 1122-1129.
87. Talavage TM, Nauman EA, Breedlove EL, Yoruk U, Dye AE, Morigaki KE, et‰al (2014) Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion. J Neurotrauma 31: 327-338.
88. Thorndike A, (1952) Serious recurrent injuries of athletes contraindications to further competitive participation. N Engl J Med 247: 554-556.
89. Tremblay S, Henry LC, Bedetti C, Larson-Dupuis C, Gagnon J-F, Evans AC, et‰al (2014) Diffuse white matter tract abnormalities in clinically normal ageing retired athletes with a history of sports-related concussions. Brain 137: 2997-3011.
90. Uhl G, McKinney M, Hedreen J, White C, Coyle J, Whitehouse P, Price D, (1982) Dementia pugilistica-loss of basal forebrain cholinergic neurons and cortical cholinergic markers. Ann Neurol 12: 99.
91. Viano DC, Casson IR, Pellman EJ, Bir CA, Zhang L, Sherman DC, Boitano MA, (2005) Concussion in professional football: comparison with boxing head impacts-part 10. Neurosurgery 57: 1154-1172, discussion -72.
92. Victoroff J, (2013) Traumatic encephalopathy: review and provisional research diagnostic criteria. Neurorehabilitation 32: 211-224.
93. Weir DR, Jackson JS, Sonnega A, (2009) National football league player care foundation study of retired NFL players. Ann Arbor: University of Michigan Institute for Social Research.
94. Margulies SS, Kilbaugh T, Sullivan S, Smith C, Propert K, Byro M, et‰al (2015) Establishing a clinically relevant large animal model platform for TBI therapy development: using cyclosporin a as a case study. Brain Pathology 25: 289-303.
95. Koerte IK, Lin AP, Willems A, Muehlmann M, Hufschmidt J, Coleman MJ, et‰al (2015) A review of neuroimaging findings in repetitive brain trauma. Brain Pathology 25: 304-335.
96. McKee AC, Stein T, Kiernan P, Alvarez V, (2015) The neuropathology of chronic traumatic encephalopathy. Brain Pathology 25: 336-350.
97. Smith C, (2015) The study and consequences of repetitive traumatic brain injury. Brain Pathology 25: 287-288.