The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): Study protocol for a randomised controlled trial

Trials

Volumn 16, Issue 1, 2015, Pages

  Lisiecka, Danuta M ^a,b   Suckling, John ^a,b,c   Barnes, Thomas R E ^d,e   Chaudhry, Imran B ^f,g   Dazzan, Paola ^h   Husain, Nusrat ^f   Jones, Peter B ^b,c   Joyce, Eileen M ⁱ   Lawrie, Stephen M ^j   Upthegrove, Rachel ^k,l   Deakin, Bill ^f,m  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e WEST LONDON MENTAL HEALTH NHS TRUST   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g Lancashire Care NHS Trust Early Intervention Service   (United Kingdom)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ UNIVERSITY COLLEGE LONDON   (United Kingdom)

^j UNIVERSITY OF EDINBURGH   (United Kingdom)

^k UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^l BIRMINGHAM AND SOLIHULL MENTAL HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^m GREATER MANCHESTER MENTAL HEALTH NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

Blood cytokines screening; Double blind randomised placebo controlled clinical trial; Magnetic resonance imaging; Mechanism of action; Medication efficacy; Minocycline; Multi centre study; Negative symptoms; Neuroprotection; Psychosis

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; MINOCYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROLEPTIC AGENT; PLACEBO; NEUROPROTECTIVE AGENT;

ADULT; AGED; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOKINE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG USE; DSM-IV; ECHO PLANAR IMAGING; FEMALE; GENERAL MENTAL DISEASE ASSESSMENT; HUMAN; INTERVENTION STUDY; MALE; MENTAL TASK; NEGATIVE SYNDROME; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATIENT CARE; POSITIVE AND NEGATIVE SYNDROME SCALE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RESTING STATE NETWORK; SOCIAL AND COGNITIVE FUNCTIONING SCORE; SOCIAL FUNCTIONING SCALE; TASK PERFORMANCE; THREE DIMENSIONAL IMAGING; WECHSLER INTELLIGENCE SCALE; WEIGHT GAIN; CLINICAL PROTOCOL; PSYCHOTIC DISORDERS;

CLINICAL PROTOCOLS; DOUBLE-BLIND METHOD; HUMANS; MAGNETIC RESONANCE IMAGING; MINOCYCLINE; NEUROPROTECTIVE AGENTS; OUTCOME ASSESSMENT (HEALTH CARE); PSYCHOTIC DISORDERS;

EID: 84928233229     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-015-0580-x     Document Type: Article

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