Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 3, 2015, Pages 670-679

  Baylay, Alison J ^a   Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Antimicrobial resistance mechanisms; Efflux; Multidrug resistance; Regulation

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER PATAB; CIPROFLOXACIN; ETHIDIUM BROMIDE; NORFLOXACIN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; GENE DISRUPTION; GENE MUTATION; LABORATORY TEST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STABILITY; STREPTOCOCCUS PNEUMONIAE; UPREGULATION; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUTATION; TRANSCRIPTION TERMINATION;

ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, BACTERIAL; FLUOROQUINOLONES; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MUTATION; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION TERMINATION, GENETIC;

EID: 84928197026     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku449     Document Type: Article

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