Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

Biotechnology Progress

Volumn 31, Issue 2, 2015, Pages 566-577

  Berry, Brandon ^a   Moretto, Justin ^a   Matthews, Thomas ^a   Smelko, John ^a   Wiltberger, Kelly ^a  

^a BIOGEN   (United States)

Author keywords

Cell culture; Multivariate analysis; Predictive modeling; Process analytical technology; Raman spectroscopy

Indexed keywords

CELL CULTURE; CELLS; FORECASTING; LEAST SQUARES APPROXIMATIONS; MANUFACTURE; METABOLITES; MONOCLONAL ANTIBODIES; MULTIVARIANT ANALYSIS; RAMAN SPECTROSCOPY; SPECTRUM ANALYSIS;

CELL CULTURE PROCESS; CLINICAL MANUFACTURING; CONCENTRATION RANGES; MULTI VARIATE ANALYSIS; PARTIAL LEAST SQUARES MODELS; PREDICTIVE MODELING; PROCESS ANALYTICAL TECHNOLOGY; SPECTRAL PREPROCESSING;

PREDICTIVE ANALYTICS;

ANIMAL; BIOLOGICAL MODEL; BIOREACTOR; BIOTECHNOLOGY; CHO CELL LINE; CRICETULUS; CULTURE TECHNIQUE; HAMSTER; MULTIVARIATE ANALYSIS; PROCEDURES; RAMAN SPECTROMETRY;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; SPECTRUM ANALYSIS, RAMAN;

EID: 84928173379     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2035     Document Type: Article

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