Amplification of pfmdr1, pfcrt, pvmdr1, and K13 propeller polymorphisms associated with Plasmodium falciparum and Plasmodium vivax isolates from the China-Myanmar border

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 5, 2015, Pages 2554-2559

  Feng, Jun ^a   Zhou, Daili ^b   Lin, Yingxue ^b   Xiao, Huihui ^a   Yan, He ^a   Xia, Zhigui ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b Yingjiang County Center for Disease Control and Prevention   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; CARRIER PROTEIN; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MDR1 PROTEIN, PLASMODIUM VIVAX; MULTIDRUG RESISTANCE PROTEIN; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CHINA; CODON USAGE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INDIGENOUS PEOPLE; K13 PROPELLER GENE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MICROBIAL GENE; MUTATOR GENE; MYANMAR; NONHUMAN; PARASITE PREVALENCE; PFCRT GENE; PFMDR1 GENE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA; POINT MUTATION; PRIORITY JOURNAL; PVMDR1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC POLYMORPHISM; GENETICS; MUTATION;

CHINA; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; MYANMAR; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; POINT MUTATION; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS;

EID: 84928140055     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.04843-14     Document Type: Article

References (46)

1. Delacollette C, D'Souza C, Christophel E, Thimasarn K, Abdur R, Bell D, Dai TC, Gopinath D, Lu S, Mendoza R, Ortega L, Rastogi R, Tantinimitkul C, Ehrenberg J. 2009. Malaria trends and challenges in the Greater Mekong Subregion. Southeast Asian J Trop Med Public Health 40:674-691.
2. Li HX, Zhang ZX, Du ZW, Chen GW, Chen ZW. 2005. Investigation into an outbreak of malaria in Lincang prefecture on China-Myanmar border and the neighboring area outside China. Zhongguo Re Dai Yi Xue 5:55-57. (In Chinese.)
3. Ministry of Health. 2010. Action plan of China malaria elimination (2010-2020). Ministry of Health, Beijing, China.
4. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ. 2009. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 361:455-467. http://dx.doi.org/10.1056/NEJMoa0808859.
5. Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, ler Moo C, Al-Saai S, Dondorp AM, Lwin KM, Singhasivanon P, Day NP, White NJ, Anderson TJ, Nosten F. 2012. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 379:1960-1966. http://dx.doi.org/10.1016/S0140-6736(12)60484-X.
6. Wellems TE, Plowe CV. 2001. Chloroquine-resistant malaria. J Infect Dis 184:770-776. http://dx.doi.org/10.1086/322858.
7. Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T. 2004. Intercontinental spread of pyrimethamine-resistant malaria. Science 305:1124. http://dx.doi.org/10.1126/science.1098876.
8. World Health Organization. 2009. Development of a strategy towards elimination of Plasmodium falciparum parasites with altered responses to artemisinins, p 1-52. World Health Organization, Geneva, Switzerland.
9. Ministry of Health. 2006. Antimalarial drug policy in China. Ministry of Health, Beijing, China.
10. Yang HL, Liu DQ, Yang YM, Fan B, Yang PF, Li XL, Li CF, Dong Y, Yang CJ. 2003. Changes in susceptibility of Plasmodium falciparum to artesunate in vitro in Yunnan Province, China. Trans R Soc Trop Med Hyg 97:226-228. http://dx.doi.org/10.1016/S0035-9203(03)90127-1.
11. Sun XD, Wang J, Li XL, Yang J, Deng Y, Lasi JH. 2014. In vitro sensitivity of Plasmodium falciparum to 6 antimalarials in the City of Laiza, Burma. Zhongguo Bing Yuan Sheng Wu Xue Za Zhi 9:561-563. (In Chinese.)
12. Carrara VI, Lwin KM, Phyo AP, Ashley E, Wiladphaingern J, Sriprawat K, Rijken M, Boel M, McGready R, Proux S, Chu C, Singhasivanon P, White N, Nosten F. 2013. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999-2011: an observational study. PLoS Med 10:e1001398. http://dx.doi.org/10.1371/journal.pmed.1001398.
13. Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D. 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1. J Infect Dis 183:1535-1538. http://dx.doi.org/10.1086/320195.
14. Djimdé A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Coulibaly D, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV. 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344:257-263. http://dx.doi.org/10.1056/NEJM200101253440403.
15. Suwanarusk R, Chavchich M, Russell B, Jaidee A, Chalfein F, Barends M, Prasetyorini B, Kenangalem E, Piera KA, Lek-Uthai U, Anstey NM, Tjitra E, Nosten F, Cheng Q, Price RN. 2008. Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax. J Infect Dis 198: 1558-1564. http://dx.doi.org/10.1086/592451.
16. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Menard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Menard D. 2014. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505:50-55. http://dx.doi.org/10.1038/nature12876.
17. World Health Organization. 2014. Status report on artemisinin resistance. World Health Organization, Geneva, Switzerland.
18. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. 2000. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 108:13-23. http://dx.doi.org/10.1016/S0166-6851(00)00201-2.
19. Brega S, Meslin B, de Monbrison F, Severini C, Gradoni L, Udomsangpetch R, Sutanto I, Peyron F, Picot S. 2005. Identification of the Plasmodium vivax mdr-like gene (pvmdr1) and analysis of single-nucleotide polymorphisms among isolates from different areas of endemicity. J Infect Dis 191:272-277. http://dx.doi.org/10.1086/426830.
20. Yang HL. 2001. Malaria control and research in Yunnan province. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 14:54-56. (In Chinese.)
21. Hastings IM. 2004. The origins of antimalarial drug resistance. Trends Parasitol 20:512-518. http://dx.doi.org/10.1016/j.pt.2004.08.006.
22. Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, et al. 2014. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 371:411-423. http://dx.doi.org/10.1056/NEJMoa1314981.
23. Yang HL, Liu DQ, Huang KG, Dong Y, Yang PF, Yang YM, Liao MZ, Zhang CY, Liu RJ. 1997. In vitro sensitivity of Plasmodium falciparum to derivatives of artemisinin, pyronardine and chloroquine in Yunnan. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 15:292-296. (In Chinese.)
24. Yang HL, Gao BH, Huang KG. 1999. Comparison of sensitivity of artesunate-sensitive and artesunate-resistant Plasmodium falciparum to chloroquine and amodiaquine. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17:353-355. (In Chinese.)
25. Zhou G, Sun L, Xia R, Duan Y, Xu J, Yang H, Wang Y, Lee MC, Xiang Z, Yan G, Cui L, Yang Z. 2014. Clinical malaria along the China-Myanmar border, Yunnan Province, China, January 2011-August 2012. Emerg Infect Dis 20:675-678. http://dx.doi.org/10.3201/eid2004.130647.
26. Wongsrichanalai C, Lin K, Pang LW, Faiz MA, Noedl H, Wimonwattrawatee T, Laoboonchai A, Kawamoto F. 2001. In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs. Am J Trop Med Hyg 65:450-455.
27. Smithuis F, Shahmanesh M, Kyaw MK, Savran O, Lwin S, White NJ. 2004. Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar. Trop Med Int Health 9:1184-1190. http://dx.doi.org/10.1111/j.1365-3156.2004.01323.x.
28. Mu J, Ferdig MT, Feng X, Joy DA, Duan J, Furuya T, Subramanian G, Aravind L, Cooper RA, Wootton JC, Xiong M, Su XZ. 2003. Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol 49:977-989. http://dx.doi.org/10.1046/j.1365-2958.2003.03627.x.
29. Sidhu AB, Uhlemann AC, Valderramos SG, Valderramos JC, Krishna S, Fidock DA. 2006. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J Infect Dis 194:528-535. http://dx.doi.org/10.1086/507115.
30. Wongsrichanalai C, Meshnick SR. 2008. Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis 14:716-719. http://dx.doi.org/10.3201/eid1405.071601.
31. Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F. 2009. Pfmdr1 copy number and artemisinin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar J 8:11. http://dx.doi.org/10.1186/1475-2875-8-11.
32. Wang Z, Parker D, Meng H, Wu L, Li J, Zhao Z, Zhang R, Fan Q, Wang H, Cui L, Yang Z. 2012. In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes. PLoS One 7:e30927. http://dx.doi.org/10.1371/journal.pone.0030927.
33. Dong Y, Li CL, Wang XR, Guo XF, Li WY, Li CF, Li L, Liu H, Li JS, Lv SS. 2005. The prevalence of malaria and control situation in Jiangcheng County of Yunnan Province. Zhongguo Re Dai Yi Xue 5:709-712. (In Chinese.)
34. Zhang GQ, Guan YY, Zheng B, Wu S, Tang LH. 2009. Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in China. Trop Med Int Health 14:1266-1271. http://dx.doi.org/10.1111/j.1365-3156.2009.02342.x.
35. Huang F, Tang L, Yang H, Zhou S, Sun X, Liu H. 2012. Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border. Malar J 11:278. http://dx.doi.org/10.1186/1475-2875-11-278.
36. Muhamad P, Chaijaroenkul W, Phompradit P, Rueangweerayut R, Tippawangkosol P, Na-Bangchang K. 2013. Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border. Asian Pac J Trop Biomed 3:931-935. http://dx.doi.org/10.1016/S2221-1691(13)60181-1.
37. Brown T, Smith LS, Oo EK, Shawng K, Lee TJ, Sullivan D, Beyrer C, Richards AK. 2012. Molecular surveillance for drug-resistant Plasmodium falciparum in clinical and subclinical populations from three border regions of Burma/Myanmar: cross-sectional data and a systematic review of resistance studies. Malar J 11:333. http://dx.doi.org/10.1186/1475-2875-11-333.
38. Guthmann JP, Pittet A, Lesage A, Imwong M, Lindegardh N, Min Lwin M, Zaw T, Annerberg A, de Radigues X, Nosten F. 2008. Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar. Trop Med Int Health 13:91-98. http://dx.doi.org/10.1111/j.1365-3156.2007.01978.x.
39. Sumawinata IW, Bernadeta, Leksana B, Sutamihardja A, Purnomo, Subianto B, Sekartuti, Fryauff DJ, Baird JK. 2003. Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua. Am J Trop Med Hyg 68:416-420.
40. Phan GT, de Vries PJ, Tran BQ, Le HQ, Nguyen NV, Nguyen TV, Heisterkamp SH, Kager PA. 2002. Artemisinin or chloroquine for blood stage Plasmodium vivax malaria in Vietnam. Trop Med Int Health 7:858-864. http://dx.doi.org/10.1046/j.1365-3156.2002.00948.x.
41. Lu F, Wang B, Cao J, Sattabongkot J, Zhou H, Zhu G, Kim K, Gao Q, Han ET. 2012. Prevalence of drug resistance-associated gene mutations in Plasmodium vivax in Central China. Korean J Parasitol 50:379-384. http://dx.doi.org/10.3347/kjp.2012.50.4.379.
42. Liang GL, Sun XD, Wang J, Zhang ZX. 2009. Sensitivity of Plasmodium vivax to chloroquine in Laza City, Myanmar. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 27:175-176. (In Chinese.)
43. Huang B, Huang S, Su XZ, Tong X, Yan J, Li H, Lu F. 2014. Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China. Malar J 13:346. http://dx.doi.org/10.1186/1475-2875-13-346.
44. Imwong M, Pukrittayakamee S, Pongtavornpinyo W, Nakeesathit S, Nair S, Newton P, Nosten F, Anderson TJ, Dondorp A, Day NP, White NJ. 2008. Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. Antimicrob Agents Chemother 52:2657-2659. http://dx.doi.org/10.1128/AAC.01459-07.
45. Li GQ, Guo XB, Fu LC, Jian HX, Wang XH. 1994. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg 88(Suppl 1):S5-S6.
46. Zhang G, Guan Y, Zheng B, Wu S, Tang L. 2008. No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China. Malar J 7:122. http://dx.doi.org/10.1186/1475-2875-7-122.