Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung

Respiratory Research

Volumn 16, Issue 1, 2015, Pages

  Sureshbabu, Angara ^a   Syed, Mansoor A ^a   Boddupalli, Chandra S ^b   Dhodapkar, Madhav V ^b   Homer, Robert J ^a   Minoo, Parviz ^c   Bhandari, Vineet ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE CANCER CENTER   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Angiopoietin; Bronchopulmonary dysplasia; Cell death; Inflammation; Newborn; Oxygen; Pulmonary; Transforming growth factor

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; CASPASE 3; ENDOGLIN; PROTEIN BAX; PROTEIN C; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; PROTEIN SERINE THREONINE KINASE; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ACUTE LUNG INJURY; AMBIENT AIR; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL SURVIVAL; CLINICAL EVALUATION; CONTROLLED STUDY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HYPEROXIA; HYPEROXIA INDUCED ACUTE LUNG INJURY; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG DEVELOPMENT; MACROPHAGE; MONOCYTE; MORPHOMETRICS; MOUSE; NEWBORN; NEWBORN MORTALITY; NICK END LABELING; NONHUMAN; PATHOGENESIS; PHENOTYPIC VARIATION; PNEUMONIA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENETICS; GENOTYPE; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; TIME FACTOR; TRANSGENIC MOUSE; UPREGULATION;

ACUTE LUNG INJURY; ALVEOLAR EPITHELIAL CELLS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DISEASE MODELS, ANIMAL; GENOTYPE; HUMANS; HYPEROXIA; LUNG; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHENOTYPE; PNEUMONIA; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84928124531     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-014-0162-6     Document Type: Article

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