Control of lung development by latent TGF-β binding proteins

Journal of Cellular Physiology

Volumn 226, Issue 6, 2011, Pages 1499-1509

  Dabovic, Branka ^a   Chen, Yan ^a,e   Choi, Jiwon ^b   Davis, Elaine C ^b   Sakai, Lynn Y ^c   Todorovic, Vesna ^a   Vassallo, Melinda ^a   Zilberberg, Lior ^a   Singh, Amanjot ^d   Rifkin, Daniel B ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

^d PACE UNIVERSITY   (United States)

^e VaxInnate Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 2; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 3; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 4; PROTEINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AIR SAC; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; CORRELATION ANALYSIS; EMPHYSEMA; ENZYME RELEASE; FEMALE; FIBER; FIBROSIS; LUNG DEVELOPMENT; LUNG MALFORMATION; MACROPHAGE; MALE; MOUSE; MUTATIONAL ANALYSIS; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; ELASTIN; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INFLAMMATION; LATENT TGF-BETA BINDING PROTEINS; LUNG; MICE; MICROFIBRILS; PHENOTYPE;

ANIMALIA; MUS;

EID: 79952710211     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22479     Document Type: Article

References (48)

1. Annes JP, Munger JS, Rifkin DB. 2003. Making sense of latent TGFbeta activation. J Cell Sci 116: 217-224.
2. Annes JP, Chen Y, Munger JS, Rifkin DB. 2004. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165: 723-734.
3. Araya J, Nishimura SL. 2010. Fibrogenic reactions in lung disease. Annu Rev Pathol 5: 77-98.
4. Bourbon JR, Boucherat O, Boczkowski J, Crestani B, Delacourt C. 2009. Bronchopulmonary dysplasia and emphysema: In search of common therapeutic targets. Trends Mol Med 15: 169-179.
5. Charbonneau NL, Carlson EJ, Tufa S, Sengle G, Manalo EC, Carlberg VM, Ramirez F, Keene DR, Sakai LY. 2010a. In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 285: 24943-24955.
6. Charbonneau NL, Jordan CD, Keene DR, Lee-Arteaga S, Dietz HC, Rifkin DB, Ramirez F, Sakai LY. 2010b. Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem 285: 20242-20251.
7. Chen Y, Dabovic B, Annes JP, Rifkin DB. 2002. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett 517: 277-280.
8. Choi J, Bergdahl A, Zheng Q, Starcher B, Yanagisawa H, Davis EC. 2009. Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly. Matrix Biol 28: 211-220.
9. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289: 420-429.
10. Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, Rifkin DB. 2005. Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol 167: 419-428.
11. Dabovic B, Chen Y, Colarossi C, Obata H, Zambuto L, Perle MA, Rifkin DB. 2002. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol. 156(2): 227-232.
12. Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB. 2008. Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. J Cell Physiol. 156: 227-232.
13. Dallas SL, Keene DR, Bruder SP, Saharinen J, Sakai LY, Mundy GR, Bonewald LF. 2000. Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo. J Bone Miner Res 15: 68-81.
14. Davis EC. 1993. Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization. Lab Invest 68: 89-99.
15. Drews F, Knobel S, Moser M, Muhlack KG, Mohren S, Stoll C, Bosio A, Gressner AM, Weiskirchen R. 2008. Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability. Biochim Biophys Acta 1783: 34-48.
16. Gleizes PE, Beavis RC, Mazzieri R, Shen B, Rifkin DB. 1996. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta 1. J Biol Chem 271: 29891-29896.
17. Guo G, Booms P, Halushka M, Dietz HC, Ney A, Stricker S, Hecht J, Mundlos S, Robinson PN. 2006. Induction of macrophage chemotaxis by aortic extracts of the mgR Marfan mouse model and a GxxPG-containing fibrillin-1 fragment. Circulation 114: 1855-1862.
18. Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD. 2006. Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest 116: 753-759.
19. Hucthagowder V, Sausgruber N, Kim KH, Angle B, Marmorstein LY, Urban Z. 2006. Fibulin-4: A novel gene for an autosomal recessive cutis laxa syndrome. Am J Hum Genet 78: 1075-1080.
20. Hyytiainen M, Penttinen C, Keski-Oja J. 2004. Latent TGF-beta binding proteins: Extracellular matrix association and roles in TGF-beta activation. Crit Rev Clin Lab Sci 41: 233-264.
21. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. 2003. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem 278: 2750-2757.
22. Koli K, Saharinen J, Hyytiainen M, Penttinen C, Keski-Oja J. 2001. Latency, activation, and binding proteins of TGF-beta. Microsc Res Tech 52: 354-362.
23. Massague J, Blain SW, Lo RS. 2000. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309.
24. McLaughlin PJ, Chen Q, Horiguchi M, Starcher BC, Stanton JB, Broekelmann TJ, Marmorstein AD, McKay B, Mecham R, Nakamura T, Marmorstein LY. 2006. Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol 26: 1700-1709.
25. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Jr., Honjo T, Chien KR. 2002. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature 415: 171-175.
26. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC. 2003. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33: 407-411.
27. Noguera I, Obata H, Gualandris A, Cowin P, Rifkin DB. 2003. Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene 308: 31-41.
28. Noor A, Windpassinger C, Vitcu I, rlic M. Rafiq MA, Khalid M, Malik MN, Ayub M, Alman B, Vincent JB. 2009. Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3. Am J Hum Genet 84: 519-523.
29. Oklu R, Metcalfe JC, Hesketh TR, Kemp PR. 1998. Loss of a consensus heparin binding site by alternative splicing of latent transforming growth factor-beta binding protein-1. FEBS Lett 425: 281-285.
30. Olofsson A, Ichijo H, Moren A, ten Dijke P, Miyazono K, Heldin CH. 1995. Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix. J Biol Chem 270: 31294-31297.
31. Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bachinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY. 2009. Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem 284: 16872-16881.
32. Penttinen C, Saharinen J, Weikkolainen K, Hyytiainen M, Keski-Oja J. 2002. Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta. J Cell Sci 115: 3457-3468.
33. Ramirez F, Dietz HC. 2009. Extracellular microfibrils in vertebrate development and disease processes. J Biol Chem 284: 14677-14681.
34. Rifkin DB. 2005. Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability. J Biol Chem 280: 7409-7412.
35. Saharinen J, Keski-Oja J. 2000. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell 11: 2691-2704.
36. Saharinen J, Taipale J, Keski-Oja J. 1996. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 15: 245-253.
37. Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, Boivin GP, Cardell EL, Doetschman T. 1997. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659-2670.
38. Senior RM, Griffin GL, Mecham RP. 1980. Chemotactic activity of elastin-derived peptides. J Clin Invest 66: 859-862.
39. Sheehan DC, Hrapchak BB. 1980. Theory and practice of histotechnology. St. Louis: Mosby.
40. Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. 2002. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 16: 2264-2273.
41. Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB. 2005. Latent TGF-beta binding proteins. Int J Biochem Cell Biol 37: 38-41.
42. Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. 2007. Long form of latent TGF-{beta} binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development 134: 3723-3732.
43. Urban Z, Gao J, Pope FM, Davis EC. 2005. Autosomal dominant cutis laxa with severe lung disease: Synthesis and matrix deposition of mutant tropoelastin. J Invest Dermatol 124: 1193-1199.
44. Wagenseil JE, Mecham RP. 2007. New insights into elastic fiber assembly. Birth Defects Res C Embryo Today 81: 229-240.
45. Wang J, Nagy A, Larsson J, Dudas M, Sucov HM, Kaartinen V. 2006a. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol 6: 51.
46. Wang Y, Zhu W, Levy DE. 2006b. Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR. Methods 39: 356-362.
47. Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, Olson EN. 2002. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415: 168-171.
48. Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB. 2008. Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci USA 105: 18758-18763.