Schlafen-11 sensitizes colorectal carcinoma cells to irinotecan

Anti-Cancer Drugs

Volumn 25, Issue 10, 2014, Pages 1175-1181

  Tian, Li ^a,b   Song, Santai ^a   Liu, Xiaojing ^a   Wang, Yan ^a   Xu, Xiaoguang ^c   Hu, Yi ^a   Xu, Jianming ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b NAVY GENERAL HOSPITAL   (China)

^c 309TH HOSPITAL OF PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FIRTECAN; IRINOTECAN; PROTEIN; SCHLAFEN 11 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; NUCLEAR PROTEIN; SLFN11 PROTEIN, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CHEMOSENSITIZATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; SCHLAFEN 11 GENE; TREATMENT RESPONSE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; COLORECTAL TUMOR; DRUG EFFECTS; DRUG RESISTANCE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; HUMANS; NUCLEAR PROTEINS; RNA, SMALL INTERFERING; TOPOISOMERASE INHIBITORS; TRANSFECTION;

EID: 84928108823     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000151     Document Type: Article

References (14)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30.
2. Wasserman E, Sutherland W, Cvitkovic E. Irinotecan plus oxaliplatin: A promising combination for advanced colorectal cancer. Clin Colorectal Cancer 2001; 1:149-153.
3. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300.
4. Dopeso H, Mateo-Lozano S, Elez E, Landolfi S, Ramos Pascual FJ, Hernández-Losa J, et al. Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment. Clin Cancer Res 2010; 16:2375-2382.
5. Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, et al. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. Proc Natl Acad Sci USA 2012; 109:15030-15035.
6. Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, et al. Role of Schlafen 2 (SLFN2) in the generation of interferon alphainduced growth inhibitory responses. J Biol Chem 2009; 284:25051-25064.
7. Geserick P, Kaiser F, Klemm U, Kaufmann SH, Zerrahn J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol 2004; 16:1535-1548.
8. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, et al. Codonusage- based inhibition of HIV protein synthesis by human schlafen 11. Nature 2012; 491:125-128.
9. Schwarz DA, Katayama CD, Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity 1998; 9:657-668.
10. Mavrommatis E, Arslan AD, Sassano A, Hua Y, Kroczynska B, Platanias LC. Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. J Biol Chem 2013; 288:33006-33015.
11. Patel BB, Yu Y, Du J, Rishi AK, Sarkar FH, Tarca AL, et al. Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. Am J Physiol Gastrointest Liver Physiol 2009; 296:G955-G962.
12. Condamine T, Le Luduec JB, Chiffoleau E, Bériou G, Louvet C, Heslan M, et al. Characterization of Schlafen-3 expression in effector and regulatory T cells. J Leukoc Biol 2010; 87:451-456.
13. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483:603-607.
14. Kiianitsa K, Maizels N. A rapid and sensitive assay for DNA-protein covalent complexes in living cells. Nucleic Acids Res 2013; 41:e104.