Schlafen 3, a novel gene, regulates colonic mucosal growth during aging

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 4, 2009, Pages

  Patel, Bhaumik B ^a,b   Yu, Yingjie ^a,b   Du, Jianhua ^a,b   Rishi, Arun K ^a   Sarkar, Fazlul H ^a,b   Tarca, Adi L ^a   Wali, Anil ^a   Majumdar, Adhip P N ^a,b,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Aging; Cancer; Gastrointestinal mucosa; Microarrays; Proliferation

Indexed keywords

COMPLEMENTARY DNA; CYCLIN D1; RETINOBLASTOMA PROTEIN; WORTMANNIN; BENPHOTHIAMINE; DRUG DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; SCHLAFEN 3 PROTEIN, RAT; THIAMINE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HCT116; COLON MUCOSA; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; MALE; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCHLAFEN 3 GENE; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTESTINE MUCOSA; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGING; ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HCT116 CELLS; HUMANS; INTESTINAL MUCOSA; MALE; PROTEINS; RATS; RATS, INBRED F344; THIAMINE;

EID: 67149131639     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90726.2008     Document Type: Article

References (28)

1. Atillasoy E, Holt PR. Gastrointestinal proliferation and aging. J Gerontol 48: B43-B49, 1993.
2. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc B 57: 289-300, 1995.
3. Brady G, Boggan L, Bowie A, O'Neill LAJ. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem 280: 30723-30734, 2005.
4. Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA-polymerase-δ. Nature 326: 515-517, 1987.
5. Chang CD, Ottavio L, Travalli S, Lipson KE, Baserga R. Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene. Mol Cell Biol 10: 3289-3296, 1990.
6. Deschner EE, Lynch HT. The influence of age and genetic risk for colon cancer on colonic epithelial cell proliferation. Proc Annl Mtg Am Assoc Cancer Res 28: 197, 1987.
7. Fry RJM, Lesher S, Kohn HI. Age effect on cell-transit time in the mouse jejunal epithelium. Am J Physiol 201: 213-216, 1961.
8. Geserick P, Kaiser F, Klemm U, Kaufmann SH, Zerrahn J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol 16: 1535-1548, 2004.
9. Heung-Man L, Greeley GH Jr, Englander EW. Effects of aging on expression of genes involved in regulation of proliferation and apoptosis in the colonic epithelium. Mech Ageing Dev 155: 139-155, 2000.
10. Holt PR, Yeh KY. Colonic proliferation is increased in senescent rats. Gastroenterology 95: 1556-1563, 1988.
11. Holt PR, Yeh KY, Kolter DP. Altered controls of proliferation in proximal small intestine of the senescent rat. Proc Natl Acad Sci USA 85: 2771-2775, 1988.
12. Lesher S, Fry RJM, Kohn HI. Age and generation time of the mouse duodenal epithelium cell. Exp Cell Res 24: 334-343, 1961.
13. Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer. Their development and application to studies of cancer prevention. Gastroenterology 92: 1083-1086, 1987.
14. Majumdar APN, Basson MD. Effect of aging on the gastrointestinal tract. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR, Barrett K, Ghishan F, Merchant JI, Said HM, Wood JD. New York: Academic, 2006, p. 405-433.
15. Majumdar APN, Du J. Phosphatidylinositol 3 kinase/Akt signaling stimulates colonic mucosal cell survival during aging. Am J Physiol Gastrointest Liver Physiol 290: G49-G55, 2006.
16. Majumdar APN, Du J, Yu Y, Xu H, Levi E, Patel BB, Rishi AK. Cell-cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging. Am J Physiol Gastrointest Liver Physiol 293: G1215-G1222, 2007.
17. Patel BB, Yu Y, Du J, Levi E, Phillip PA, Majumdar APN. Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun 378: 344-347, 2009.
18. Roncucci L, Ponz de Leon M, Scalmati A, Malagoli G, Pratissoli S, Perini M, Chahin NJ. The influence of age on colonic epithelial cell proliferation. Cancer 62: 2373-2377, 1988.
19. Rustgi A. Oncogene and tumor suppressor genes. In: Gastrointestinal Cancers: Biology, Diagnosis, and Therapy, edited by Rustgi AK. Philadelphia, PA: Lippincott-Raven, 1995, p. 65-76.
20. Schmelz EM, Levi E, Du J, Majumdar APN:. Loss of expression of EGF-receptor related peptide (ERRP) in the aging colon: a risk factor for colorectal cancer. Mech Ageing Dev 125: 917-922, 2004.
21. Schwarz DA, Katayama CD, Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity 9: 657-668, 1998.
22. Sohn WJ, Kim D, Lee KW, Kim MS, Kwon S, Lee Y, Kim DS, Kwon HJ. Novel transcriptional regulation of the Schlafen-2 gene in macrophages in response to TLR-triggered stimulation. Mol Immunol 44: 3273-3282, 2007.
23. Smyth GK, Limma L. Liner models for microarray data. In: Bioinformatics and Computational Biology Solutions Using R and Bioconductor, edited by Gentleman R, Carey V, Duoit S, Irizarry R, Huber W. New York: Springer, 2005, p. 397-420.
24. Tarca AL, Carey VJ, Chen XW, Romero R, Drãghici S. Machine learning and its applications to biology. PLoS Comput Biol 3: e116, 2007.
25. Tureaud J, Sarkar FH, Fligiel SE, Kulkarni S, Jaszewski R, Reddy K, Yu Y, Majumdar AP. Increased expression of EGFR in gastric mucosa of aged rats. Am J Physiol Gastrointest Liver Physiol 273: G389-G398, 1997.
26. Xiao ZQ, Moragoda L, Jaszewski R, Hatfield JA, Fligiel SE, Majumdar APN. Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. Mech Ageing Dev 122: 1849-1864, 2001.
27. 1 phase in the colonic mucosa of rats. Mech Ageing Dev 116: 1-14, 2000.
28. Yan N, Shi Y. Mechanisms of apoptosis through structural biology. Annu Rev Cell Dev Biol 21: 35-56, 2005.