Expression and regulatory effects of Murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 33006-33015

  Mavrommatis, Evangelos ^a,b   Arslan, Ahmet Dirim ^a   Sassano, Antonella ^a,b   Hua, Youjia ^a   Kroczynska, Barbara ^a   Platanias, Leonidas C ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC EFFECT; CELL-CYCLE PROGRESSION; CELLULAR PROLIFERATIONS; FUNCTIONAL RELEVANCE; MALIGNANT MELANOMA; REGULATORY EFFECTS; RENAL CELL CARCINOMA; SYSTEMATIC ANALYSIS;

CELL PROLIFERATION; CELLS; CYTOLOGY; DERMATOLOGY; GENE THERAPY; MAMMALS; ONCOLOGY;

GENE EXPRESSION;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; KIDNEY CARCINOMA; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHLAFEN GENE; SIGNAL TRANSDUCTION; SLFN2 GENE; SLFN3 GENE; SLFN5 GENE; UPREGULATION;

ANTIVIRAL AGENTS; CELL DEATH; INNATE IMMUNITY; INTERFERON; SCHLAFEN; SIGNAL TRANSDUCTION; SIGNALING;

ANIMALS; ANTIVIRAL AGENTS; CARCINOMA, RENAL CELL; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; INTERFERON-GAMMA; KIDNEY NEOPLASMS; MELANOMA; MICE; NEOPLASM PROTEINS; UP-REGULATION;

EID: 84887849814     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.460741     Document Type: Article

References (28)

1. Schwarz, D. A., Katayama, C. D., and Hedrick, S. M. (1998) Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity 9, 657-668
2. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., and de la Casa-Esperón, E. (2009) Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene 447, 1-11
3. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H., and Zerrahn, J. (2004) Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immunol. 16, 1535-1548
4. Brady, G., Boggan, L., Bowie, A., and O'Neill, L. A. (2005) Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J. Biol. Chem. 280, 30723-30734
5. Bell, T. A., de la Casa-Esperón, E., Doherty, H. E., Ideraabdullah, F., Kim, K., Wang, Y., Lange, L. A., Wilhemsen, K., Lange, E. M., Sapienza, C., and de Villena, F. P. (2006) The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11. Genetics 172, 411-423
6. Sohn, W. J., Kim, D., Lee, K. W., Kim, M. S., Kwon, S., Lee, Y., Kim, D. S., and Kwon, H. J. (2007) Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation. Mol. Immunol. 44, 3273-3282
7. Neumann, B., Zhao, L., Murphy, K., and Gonda, T. J. (2008) Subcellular localization of the Schlafen protein family. Biochem. Biophys. Res. Commun. 370, 62-66
8. Lee, N. K., Choi, H. K., Yoo, H. J., Shin, J., and Lee, S. Y. (2008) RANKLinduced schlafen2 is a positive regulator of osteoclastogenesis. Cell Signal. 20, 2302-2308
9. Katsoulidis, E., Carayol, N., Woodard, J., Konieczna, I., Majchrzak-Kita, B., Jordan, A., Sassano, A., Eklund, E. A., Fish, E. N., and Platanias, L. C. (2009) Role of Schlafen 2 (SLFN2) in the generation of interferon α-induced growth inhibitory responses. J. Biol. Chem. 284, 25051-25064
10. Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., Moresco, E. M., Satoh, T., Takeuchi, O., Akira, S., and Beutler, B. (2010) An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat. Immunol. 11, 335-343
11. Horton, M. R., and Powell, J. D. (2010) Quieting T cells with Slfn2. Nat. Immunol. 11, 281-282
12. Ahmadi, S., and Veinotte, L. L. (2011) Effect of Schlafen 2 on natural killer and T cell development from common T/natural killer progenitors. Pak. J. Biol. Sci. 14, 1002-1010
13. Patel, V. B., Yu, Y., Das, J. K., Patel, B. B., and Majumdar, A. P. (2009) Schlafen-3: a novel regulator of intestinal differentiation. Biochem. Biophys. Res. Commun. 388, 752-756
14. Yuan, L., Yu, Y., Sanders, M. A., Majumdar, A. P., and Basson, M. D. (2010) Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. Am. J. Physiol. Gastrointest. Liver Physiol. 298, G994-G1003
15. Condamine, T., Le Luduec, J. B., Chiffoleau, E., Bériou, G., Louvet, C., Heslan, M., Tilly, G., and Cuturi, M. C. (2010) Characterization of Schlafen-3 expression in effector and regulatory T cells. J. Leukoc. Biol. 87, 451-456
16. Patel, B. B., Yu, Y., Du, J., Rishi, A. K., Sarkar, F. H., Tarca, A. L., Wali, A., and Majumdar, A. P. (2009) Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G955-962
17. van Zuylen, W. J., Garceau, V., Idris, A., Schroder, K., Irvine, K. M., Lattin, J. E., Ovchinnikov, D. A., Perkins, A. C., Cook, A. D., Hamilton, J. A., Hertzog, P. J., Stacey, K. J., Kellie, S., Hume, D. A., and Sweet, M. J. (2011) Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. PloS One 6, e15723
18. Katsoulidis, E., Mavrommatis, E., Woodard, J., Shields, M. A., Sassano, A., Carayol, N., Sawicki, K. T., Munshi, H. G., and Platanias, L. C. (2010) Role of interferon α (IFNα)-inducible Schlafen-5 in regulation of anchorageindependent growth and invasion of malignant melanoma cells. J. Biol. Chem. 285, 40333-40341
19. Hamburger, A. W., and Salmon, S. E. (1977) Primary bioassay of human tumor stem cells. Science 197, 461-463
20. Uddin, S., Majchrzak, B., Woodson, J., Arunkumar, P., Alsayed, Y., Pine, R., Young, P. R., Fish, E. N., and Platanias, L. C. (1999) Activation of the p38 mitogen-activated protein kinase by type I interferons. J. Biol. Chem. 274, 30127-30131
21. Verma, A., Deb, D. K., Sassano, A., Uddin, S., Varga, J., Wickrema, A., and Platanias, L. C. (2002) Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-β on normal hematopoiesis. J. Biol. Chem. 277, 7726-7735
22. Bukowski RM. (2010) Systemic therapy for metastatic renal cell carcinoma in treatment naïve patients: a risk-based approach. Expert Opin. Pharmacother. 11, 2351-2362
23. Ascierto, P. A., Gogas, H. J., Grob, J. J., Algarra, S. M., Mohr, P., Hansson, J., and Hauschild, A. (2013) Adjuvant interferon alfa in malignant melanoma: An interdisciplinary and multinational expert review. Crit. Rev. Oncol. Hematol. 85, 149-161
24. Moschos, S., Varanasi, S., and Kirkwood, J. M. (2005) Interferons in the treatment of solid tumors. Cancer Treat. Res. 126, 207-241
25. Mavrommatis E, Fish EN, Platanias LC. (2013) The schlafen family of proteins and their regulation by interferons. J. Interferon Cytokine Res. 33, 206-210
26. Parmar, S., and Platanias, L. C. (2003) Interferons: mechanisms of action and clinical applications. Curr. Opin. Oncol. 15, 431-439
27. Bracarda, S., Eggermont, A. M., and Samuelsson, J. (2010) Redefining the role of interferon in the treatment of malignant diseases. Eur. J. Cancer 46, 284-297
28. Tefferi, A., and Vainchenker, W. (2011) Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies. J. Clin. Oncol. 29, 573-582