Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration

Chemical Science

Volumn 6, Issue 5, 2015, Pages 2812-2821

  Yang, Yongliang ^a   Li, Guohui ^b   Zhao, Dongyu ^a   Yu, Haoyang ^c   Zheng, Xiliang ^d   Peng, Xiangda ^b   Zhang, Xiaoe ^a   Fu, Ting ^b   Hu, Xiaoqing ^a   Niu, Mingshan ^a   Ji, Xuefei ^c   Zou, Libo ^c   Wang, Jin ^d,e  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^e STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMMERCE; DISEASES; ENZYME INHIBITION; ENZYMES; OBJECT RECOGNITION;

ACETYLCHOLINESTERASE; COMPUTATIONAL STRATEGY; EXPERIMENTAL VERIFICATION; LOCAL BINDING SITES; MICROMOLAR CONCENTRATION; NEURODEGENERATIVE DISORDERS; OBJECT RECOGNITION TESTS; TYROSINE KINASE INHIBITOR;

NEURODEGENERATIVE DISEASES;

EID: 84928104493     PISSN: 20416520     EISSN: 20416539     Source Type: Journal    
DOI: 10.1039/c4sc03416c     Document Type: Article

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