Predicting polypharmacology by binding site similarity: From kinases to the protein universe

Journal of Chemical Information and Modeling

Volumn 50, Issue 8, 2010, Pages 1418-1431

  Milletti, Francesca ^a,b   Vulpetti, Anna ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; DRUG INTERACTIONS; FORECASTING;

BINDING POCKETS; HUMAN GENOMES; INHIBITION PROFILE; KINASE INHIBITORS; PHARMACEUTICAL INDUSTRY; SIDE EFFECT; STRUCTURAL SIMILARITY; SYSTEM BIOLOGY;

ENZYMES;

PROTEIN; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; HUMAN; METABOLISM; PROTEIN BINDING;

BINDING SITES; DRUG DESIGN; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEINS;

EID: 77956040404     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci1001263     Document Type: Article

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