Cold-inducible RNA-binding protein promotes the development of liver cancer

Cancer Science

Volumn 106, Issue 4, 2015, Pages 352-358

  Sakurai, Toshiharu ^a   Yada, Norihisa ^a   Watanabe, Tomohiro ^b   Arizumi, Tadaaki ^a   Hagiwara, Satoru ^a   Ueshima, Kazuomi ^a   Nishida, Naoshi ^a   Fujita, Jun ^b   Kudo, Masatoshi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CD133; HCC; Recurrence; ROS; Stem cell

Indexed keywords

BUTYLATED HYDROXYANISOLE; CD133 ANTIGEN; COLD INDUCIBLE RNA BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN; STAT3 PROTEIN; THIOACETAMIDE; UNCLASSIFIED DRUG; ANTIOXIDANT; CIRBP PROTEIN, MOUSE; GLYCOPROTEIN; INTERLEUKIN-6, MOUSE; LEUKOCYTE ANTIGEN; PEPTIDE; SOX2 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ARTICLE; CANCER RECURRENCE; CANCER RISK; CARCINOGENICITY; CORRELATIONAL STUDY; HUMAN; HUMAN TISSUE; KUPFFER CELL; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER DEVELOPMENT; MALE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CANCER STEM CELL; CELL TRANSFORMATION; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; LIVER; LIVER TUMOR; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; TISSUE FIXATION; TUMOR RECURRENCE;

ANIMALS; ANTIGENS, CD; ANTIOXIDANTS; BUTYLATED HYDROXYANISOLE; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; KUPFFER CELLS; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS; OXIDATIVE STRESS; PEPTIDES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SOXB1 TRANSCRIPTION FACTORS; STAT3 TRANSCRIPTION FACTOR; THIOACETAMIDE; TISSUE FIXATION;

EID: 84928063128     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12611     Document Type: Article

References (46)

1. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339-46.
2. Moudgil V, Redhu D, Dhanda S, Singh J. A review of molecular mechanisms in the development of hepatocellular carcinoma by aflatoxin and hepatitis B and C viruses. J Environ Pathol Toxicol Oncol 2013; 32: 165-75.
3. White DL, Kanwal F, El-Serag HB. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol 2012; 10: 1342-59.e2.
4. Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983; 221: 1256-64.
5. Woo RA, Poon RY. Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev 2004; 18: 1317-30.
6. Nikolaou K, Sarris M, Talianidis I. Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer. Clin Cancer Res 2013; 19: 2810-6.
7. Sakurai T, Kudo M. Molecular link between liver fibrosis and hepatocellular carcinoma. Liver Cancer 2013; 2: 365-6.
8. Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001; 35: 297-306.
9. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-11.
10. Oishi N, Yamashita T, Kaneko S. Molecular biology of liver cancer stem cells. Liver Cancer 2014; 3: 71-84.
11. Ma S, Chan KW, Hu L et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132: 2542-56.
12. Boumahdi S, Driessens G, Lapouge G et al. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 2014; 511: 246-50.
13. Lengerke C, Fehm T, Kurth R et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer 2011; 11: 42.
14. Liu K, Jiang M, Lu Y et al. Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell 2013; 12: 304-15.
15. Gupta DN. Production of cancer of the bile ducts with thioacetamide. Nature 1955; 175: 257.
16. Sakurai T, Kudo M, Umemura A et al. p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 2013; 73: 215-24.
17. Zimmermann T, Müller A, Machnik G et al. Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje: WIST rats. Z Versuchstierkd 1987; 30: 165-80.
18. Nishiyama H, Itoh K, Kaneko Y et al. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J Cell Biol 1997; 137: 899-908.
19. Fujita J. Cold shock response in mammalian cells. J Mol Microbiol Biotechnol 1999; 1: 243-55.
20. Wellmann S, Bührer C, Moderegger E et al. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J Cell Sci 2004; 117: 1785-94.
21. Yang C, Carrier F. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. J Biol Chem 2001; 276: 47277-84.
22. Saito K, Fukuda N, Matsumoto T et al. Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein. Brain Res 2010; 1358: 20-9.
23. De Leeuw F, Zhang T, Wauquier C et al. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp Cell Res 2007; 313: 4130-44.
24. Yang R, Weber DJ, Carrier F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Nucleic Acids Res 2006; 34: 1224-36.
25. Morf J, Rey G, Schneider K et al. Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science 2012; 338: 379-83.
26. Qiang X, Yang WL, Wu R et al. Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med 2013; 19: 1489-95.
27. Artero-Castro A, Callejas FB, Castellvi J et al. Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation. Mol Cell Biol 2009; 29: 1855-68.
28. Sakurai T, Itoh K, Higashitsuji H et al. Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim Biophys Acta 2006; 1763: 290-5.
29. Sakurai T, Kashida H, Watanabe T et al. Stress response protein Cirp links inflammation and tumorigenesis in colitis-associated cancer. Cancer Res 2014; 74: 6119-28.
30. Masuda T, Itoh K, Higashitsuji H et al. Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proc Natl Acad Sci U S A 2012; 109: 10885-90.
31. Naugler WE, Sakurai T, Kim S et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-4.
32. Sakurai T, He G, Matsuzawa A et al. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 2008; 14: 156-65.
33. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121: 977-90.
34. He G, Yu GY, Temkin V et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 2010; 17: 286-97.
35. Myung SJ, Yoon JH, Yu SJ. STAT3&Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells. Biomed Pharmacother 2012; 66: 612-6.
36. Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 2006; 103: 10544-51.
37. Imamura H, Matsuyama Y, Tanaka E et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003; 38: 200-7.
38. Lo RC, Ng IO. Hepatic progenitor cells: their role and functional significance in the new classification of primary liver cancers. Liver Cancer 2013; 2: 84-92.
39. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51: 794-8.
40. Smith J, Ladi E, Mayer-Proschel M, Noble M. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci U S A 2000; 97: 10032-7.
41. Grek CL, Tew KD. Redox metabolism and malignancy. Curr Opin Pharmacol 2010; 10: 362-8.
42. Diehn M, Cho RW, Lobo NA et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009; 458: 780-3.
43. Le Belle JE, Orozco NM, Paucar AA et al. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell 2011; 8: 59-71.
44. Myant KB, Cammareri P, McGhee EJ et al. ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell 2013; 12: 761-73.
45. Kim DY, Han KH. Epidemiology and surveillance of hepatocellular carcinoma. Liver Cancer 2012; 1: 2-14.
46. Qi P, Cheng SQ, Wang H, Li N, Chen YF, Gao CF. Serum microRNAs as biomarkers for hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection. PLoS One 2011; 6: e28486.