Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Guan, Min ^a   Su, Leila ^a   Yuan, Yate Ching ^a   Li, Haiqing ^a   Chow, Warren A ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Molecular Medicine Beckman Research Institute of the City of Hope ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ATF6 PROTEIN, HUMAN; MBTPS2 PROTEIN, HUMAN; METALLOPROTEINASE; NELFINAVIR; PROTEIN BCL 2; PROTEIN PRECURSOR; RNA; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTOME;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; CLUSTER ANALYSIS; DRUG EFFECTS; ENZYMOLOGY; HUMAN; MALE; METABOLISM; METHANOCALDOCOCCACEAE; PATHOLOGY; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PROTEIN DEGRADATION; SEQUENCE ANALYSIS; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CLUSTER ANALYSIS; HUMANS; MALE; METALLOENDOPEPTIDASES; METHANOCALDOCOCCACEAE; NELFINAVIR; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PROTEIN PRECURSORS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA; SEQUENCE ANALYSIS, RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTOME;

EID: 84928028956     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09698     Document Type: Article

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