Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism

Cellular Signalling

Volumn 27, Issue 7, 2015, Pages 1426-1438

  Chen, Jing ^a,b   Zhang, Rumin ^b   Chen, Xiaoyu ^c   Wang, Chunmei ^b   Cai, Xin ^b   Liu, Haiqing ^c   Jiang, Yunlu ^b   Liu, Chuanxin ^b   Bai, Bo ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b JINING MEDICAL UNIVERSITY   (China)

^c TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

Bioluminescence resonance energy transfer (BRET); F rster resonance energy transfer (FRET); G protein coupled receptor (GPCR); Heterodimerization; Kappa opioid receptor (KOR); Orexin (hypocretin) receptor 1 (OX1R)

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNAMIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; KAPPA OPIATE RECEPTOR; OREXIN 1 RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA; UNCLASSIFIED DRUG; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; OREXIN; OREXIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CALCIUM CELL LEVEL; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPRESSION; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION REGULATION; HEK293 CELL LINE; HETERODIMERIZATION; HIPPOCAMPAL NEURONAL CULTURE; HYPOTHALAMUS; MALE; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REWARD; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; UPREGULATION; ANIMAL; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; HUMAN; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CALCIUM; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MALE; OREXIN RECEPTORS; OREXINS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION;

EID: 84928014562     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.03.027     Document Type: Article

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