Synthesis, physicochemical and kinetic studies of redox derivative of bis(2-chloroethylamine) as alkylating cytotoxic agent for brain delivery

Arabian Journal of Chemistry

Volumn 8, Issue 3, 2015, Pages 380-387

  Singh, Rajesh K ^a   Prasad, D N ^a   Bhardwaj, T R ^b,c  

^a Shivalik College of Pharmacy   (India)

^b PANJAB UNIVERSITY   (India)

^c ISF COLLEGE OF PHARMACY   (India)

Author keywords

Alkylating agent; Blood brain barrier; Kinetic study; NBP assay; Physico chemical parameters

Indexed keywords

BLOOD; DRUG PRODUCTS; KINETIC THEORY; KINETICS; PYRIDINE; REDOX REACTIONS; SILVER COMPOUNDS; SPECTROSCOPIC ANALYSIS; URANIUM METALLOGRAPHY; VANADIUM METALLOGRAPHY;

ALKYLATING AGENTS; ANTI-CANCER AGENTS; BLOOD-BRAIN BARRIER; KINETIC STUDY; PHYSICO - CHEMICAL PARAMETERS; PSEUDO FIRST-ORDER KINETICS; RATE OF OXIDATIONS; SPECTROSCOPIC STUDIES;

SOFTWARE AGENTS;

EID: 84927966830     PISSN: 18785352     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arabjc.2012.11.005     Document Type: Article

References (23)

1. Al-Obaid A.M., Farag H.A., Khalil A.A., Al-Shabanah O.A., Abdel Hamide S.G., EI-Kashef, Ahmed H.S., Al-Affifi A.M., Gadkariem E.A., EI-Subbagh H.I. Saudi Pharm. J. 2006, 14(1):1.
2. Ambrose J., Sheng-He H. Curr. Drug Targets Infect. Disord. 2005, 5:65.
3. Bartzatt R.L. Drug Deliv. 2004, 11:19.
4. Bodor N., Farag H., Brewster M.E. Science 1981, 214:1370.
5. Bodor N., Venkatraghavan V., Windwood D., Estes K., Brewster E. Int. J. Pharm. 1989, 53:195.
6. Clark D. J. Pharm. Sci. 1999, 8(88):815.
7. El-Sherbeny M.A., Al-Salem H.S., Sultan M.A., Radwan M.A., Farag H.A., Ei-Subbagh H.I. Arch. Pharm. 2003, 336(10):445.
8. Ertl P., Rohde B., Selzer P. J. Med. Chem. 2000, 43:3714.
9. Fujita T., Iwasa J., Hansch C. J. Am. Chem. Soc. 1964, 86:5175.
10. Genka S., Deutsch J., Shetty U.H., Stahle P.L., John V., Lieberburg I.M., Ali-Osman F., Rapoport S.I., Greig N.H. Clin. Exp. Metastatis 1993, 11:131.
11. Jemal A., Siegel R., Xu J., Ward E. Cancer Stat. 2010, 60:277.
12. Kelder J., Grootenhuis P., Bayada D., Delbressine L., Ploemen J. Pharm. Res. 1999, 10(16):1514.
13. Lipinski C., Lombardo F., Dominy B., Feeney P. Adv. Drug Deliv. Rev. 1997, 23:3.
14. Liu, X., Testa, B., Fahr, A., Pharm. Res., 28, 962, in press. doi: doi:10.1007/s11095-010-0303-7.
15. Molinspiration Cheminformatics, Bratislava, Slovak Republic. Available from: http://www.molinspiration.com/services/properties.html.
16. Moriguchi I., Hirono S., Liu Q., Nakagome I., Matsushita Y. Chem. Pharm. Bull. 1992, 40:127.
17. Palm K., Luthman K., Ungell A., Strandluno G., Artusson P. J. Pharm. Sci. 1996, 1(85):32.
18. Palm K., Stenberg P., Luthman K., Artursson P. Pharm. Res. 1997, 14(5):568.
19. Pen A., Samanta S., Dutta S., Saxena A.K., Shanmugavel M., Kampasi S., Quazi G.N., Sanyal U. Exp. Oncol. 2002, 24:173.
20. Peng G.W., Marquez V.E., Driscoll J.S. J. Med. Chem. 1975, 18(8):846.
21. Pettit G.R., Blonda D.S., Harrington E.C. Can. J. Chem. 1963, 41:2962.
22. Prokai L., Prokai-Tatrai K., Bodor N. Med. Res. Rev. 2000, 20:367.
23. Raghavan K.S., Shek E., Bodor N. Anticancer Drug Des. 1987, 2(1):25.