Synthesis and investigation of novel shelf-stable, brain-specific chemical delivery system

Saudi Pharmaceutical Journal

Volumn 14, Issue 1, 2006, Pages 1-15

  Al Obaid, Abdulrahman M ^a   Farag, Hassan A ^a   Khalil, Ashraf A ^a   Al Shabanah, Othman A ^a   Abdel Hamide, Sami G ^a   El Kashef, Hassan A ^a   Ahmed, Hassan S ^a   Al Affifi, Ahmed M ^a   Gadkariem, Elrasheed A ^a   El Subbagh, Hussein I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Chemical delivery systems; MAO inhibitors; Synthesis

Indexed keywords

1 (ETHOXY CARBONYLMETHYL) 3,5 BIS[N (2 FLUOROBENZYLIDENEAMINO)CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1,4 DIHYDROPYRIDINE; DIHYDROPYRIDINE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; N (ETHOXYCARBONYLMETHYL) 3,5 BIS[N (2 FLUOROBENZYLIDENEAMINO)CARBAMOYL]PYRIDIUM BROMIDE; OXIDOREDUCTASE; PYRIDINE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG OXIDATION; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PH MEASUREMENT; POWDER; RAT; TEMPERATURE DEPENDENCE;

EID: 33344470113     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gallardo A, Parejo C, Roman J. NSAIDs bound to methacrylic carriers. J. Control Release 2001; 71:127-40.
2. Goskonda VR, Ghandehari H, Reddy IK. Novel site-specific chemical delivery system as a potential mydriatic agent. J Pharm Sci 2001; 90:12-22.
3. Foldvari M. Non-invasive administration of drugs through skin. Pharm Sci Technol 2000; 3:417-25.
4. Yoon SH, Wu J, Wu WM, Prokai L, Bodor N. Brain-targeted chemical delivery of [Leu 2, Pip 3]-TRH. Bioorg Med Chem 2000; 8:1059-63.
5. Yoshikawa T, Sakaeda T, Sugawara T, Hirano K, Stella VJ. A novel chemical delivery system for brain targeting. Adv Drug Deliv Rev. 1999; 36:255-75.
6. Prokai L, Prokai-Tatrai K, Bodor N. Targeting drugs to the brain by redox chemical delivery systems. Med Res Rev 2000; 20:367-416.
7. Bodor N, Brewester M. Problems of delivery drugs to the brain. Pharm Ther 1983; 19:337-86.
8. Bodor N, Farag H, Brewester M. Improved delivery through biological membranes. J Med Chem 1983; 26:313-18.
9. Omar F, Farag H, Bodor N. Synthesis and evaluation of a redox chemical delivery system. J Drug Targeting. 1994; 2:309-12.
10. Bodor N, Farag H. Improved delivery through biological membranes. J Pharm Sci 1984; 73:385-92.
11. Bodor N, Prokai L, Farag H, Simpkins J. A strategy for delivering peptides in the central nervous system. Science 1992; 257:1698-700.
12. Woodard P, Winwood D, Brewester M, Bodor N. unproved delivery through biological membranes. Drug Des Del 1990; 6:15-28.
13. Sheha M, Al-Tayeb A, El-Sherief H, Farag H. New carrier for specific delivery of drugs to the brain. Bioorg Med Chem. 2003; 11:1865-72.
14. Horwell D. Drugs in central nervous system disorders, Marcel Dekker Inc., New York, NY. 1985; 71-121.
15. Haefely W, Burkard W, Cesura A, Kettler R. A prototype RIMA. Psychopharmacology 1992; 106:6-14.
16. Wouters J. Structural aspects of monoamine oxidase and its reversible inhibition. Current Med Chem 1998; 5:137-62.
17. Weissbach H, Smith TE, Daly JW, Witkop B, Udenfriend S. A rapid spectrophotometric assay of monoamine oxidase based on the rate of disappearance of kynuramine. J Biol Chem 1960; 235:1160-63.
18. Litchfield, J, Wilcoxon T. A simplified method of evaluating dose effect experiments. J Pharmaocol Exp Ther 1949; 96:99-109.
19. Szmant H, Harmuth C. Synthesis of some new hydrazones. J Am Chem Soc 1959; 81:962-75.
20. Eliel E, Mcbride R, Kaufmann S. Synthesis of some dihydrazides of pyridine dicarboxylic acids. J Am Chem Soc 1953; 75:4291-6.