Synthesis, in vitro and in vivo Evaluation of a Delivery System for Targeting Anticancer Drugs to the Brain

Archiv der Pharmazie

Volumn 336, Issue 10, 2003, Pages 445-455

  El Sherbeny, Magda A ^a   Al Salem, Huda S ^a   Sultan, Maha A ^a   Radwan, Mahasen A ^a   Farag, Hassan A ^b   El Subbagh, Hussein I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

Author keywords

Alkylating activity; Anticancer drug; Brain delivery system

Indexed keywords

1 (4 BROMOBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1 (4 BROMOBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL]PYRIDINIUM BROMIDE; 1 (4 CHLOROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1 (4 CHLOROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL]PYRIDINIUM CHLORIDE; 1 (4 FLUOROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1 (4 FLUOROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL]PYRIDINIUM BROMIDE; 1 (4 NITROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1 (4 NITROBENZYL) 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL]PYRIDINIUM BROMIDE; 1 BENZYL 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL] 1,4 DIHYDROPYRIDINE; 1 BENZYL 3 [N [2 BIS(2 CHLOROETHYL)AMINOETHYL]CARBAMOYL]PYRIDINIUM BROMIDE; 1,4 DIHYDROPYRIDINE; 1,4 DIHYDROPYRIDINE DERIVATIVE; ALKYLATING AGENT; AMIDE; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; DRUG CARRIER; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONCEPT FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; MALE; MODEL; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT; REDUCTION; TECHNIQUE; TISSUE SPECIFICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN; DIHYDROPYRIDINES; DRUG CARRIERS; MALE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

EID: 0242596294     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300760     Document Type: Article

References (21)

1. nd ed (Ed.: C. Craig; R. Stitzel), Little, Brown, and Company, Boston, Toronto, USA, 1986, pp. 96-109.
2. M. Mort, Modern Drug Dis., 2000, 3, 30-34.
3. Y. Chien, Controlled Drug Release from Polymeric Delivery Systems in Drug Delivery Systems (Ed.: R. Juliano), Oxford Univ. Press, Oxford, UK. 1980, pp. 11-83.
4. S. Rapoport, Sites and Functions of the Blood-Brain Barrier in: Blood-Brain Barrier in Physiology and Medicine (Ed.: S. Rapoport), Raven Press. New York, 1976, pp. 43-86.
5. P. Chem, N. Bodor, W. Wu, L. Prokai, J. Med. Chem., 1998, 41, 3773-3781.
6. K. Rana, N. Bodor, A. Elkoussi, I. Raad, A. Miyake, H. Houck, N. Gilder-Sleeve, J. Med. Virol., 1986, 20, 1-8.
7. W. Anderson, J. Simpkins, P. Woodard, D. Winood, W. Stern, N. Bodor, Psychopharmacology (Berl.), 1987, 92, 157-163.
8. N. Greig, E. Daly, D. Sweeney, S. Rapoport, Cancer Chemother. Pharmacol., 1990, 25, 320-325.
9. P. Krogsgaard-Larsen, A. Christiansen, Eur. J. Med. Chem., 1979, 14, 157-164.
10. M. Brewster, K. Raghavan, E. Pop, N. Bodor, Antimicrob. Agents Chemother., 1994, 38, 817-823.
11. E. Pop, N. Bodor, Review - Epilepsy Res., 1992, 13, 1-16.
12. K. Raghavan, T. Loftsson, M. Brewster, N. Bodor, Pharm. Res., 1992, 9, 743-749.
13. M. Brewster, E. Pop, A. Braunstein, A. Pop, A. Druzgala, A. Drinculescu, W. Anderson, A. Elkoussi, N. Bodor, Pharm. Res., 1993, 10, 1356-1362.
14. M. Brewster, M. Bartruff, W. Anderson, P. Druzgala, N. Bodor, E. Pop, J. Med. Chem., 1994, 37, 4237-4244.
15. U. Eisner, J. Kuthan, Chem. Rev., 1972, 72, 1.
16. N. Bodor, H. Farag, F. Omar, Pharm. Sci., 1995, 1, 301-306.
17. K. Raghavan, E. Shek, N. Bodor, Anti-Cancer Drug Des., 1987, 2, 25-36.
18. N. Bodor, V. Venkatraghavan, D. Winwood, K. Estes, M. Brewster, Int. J. Pharm., 1989, 53, 195-208.
19. M. Brewster, A. Simay, K. Czako, D. Winwood, H. Farag, N Bodor, J. Org. Chem., 1989, 54, 3721-3725.
20. N. Bodor, J. Simpkins, Science, 1983, 221, 65-67.
21. N.A. El-Koussi, Ph.D. Thesis, Faculty of Pharmacy, Assiut University, 1989.