Salvianolic acid B protects against Acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

Journal of Pharmacological Sciences

Volumn 127, Issue 2, 2015, Pages 203-210

  Lin, Musen ^a   Zhai, Xiaohan ^a   Wang, Guangzhi ^a   Tian, Xiaofeng ^a   Gao, Dongyan ^a   Shi, Lei ^a   Wu, Hang ^a   Fan, Qing ^a   Peng, Jinyong ^a   Liu, Kexin ^a   Yao, Jihong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Acetaminophen hepatotoxicity; Nrf2; Phase ii enzyme; PI3K; PKC; Salvianolic acid B (SalB)

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTOPORPHYRIN ZINC; SALVIANOLIC ACID B; TRANSCRIPTION FACTOR NRF2; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BENZOFURAN DERIVATIVE; NFE2L2 PROTEIN, MOUSE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; HEPG2 CELL LINE; INBRED MOUSE STRAIN; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; SALVIA MILTIORRHIZA; UPREGULATION; XENOBIOTIC METABOLISM;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BENZOFURANS; CELL DEATH; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HEP G2 CELLS; HUMANS; MALE; METABOLIC DETOXICATION, PHASE II; MICE, INBRED STRAINS; NF-E2-RELATED FACTOR 2; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84927950991     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2014.12.010     Document Type: Article

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